{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:10:04Z","timestamp":1790511004665,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Cardiac allograft vasculopathy is an accelerated fibroproliferative process that affects the coronary arteries of transplanted hearts. Intracoronary imaging with optical coherence tomography enables detection of subangiographic cardiac allograft vasculopathy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              At the time of routine surveillance coronary angiography, 48 consecutive heart transplant recipients underwent optical coherence tomographic imaging of 1 coronary artery. Imaging findings were compared per rejection history that was graded according to the International Society of Heart and Lung Transplantation classification as none\/mild (International Society of Heart and Lung Transplantation 0, 1A\/1B, or 2) or high-grade rejection (\u22653A). Compared with the none\/mild rejection group (37 patients) using Mann\u2013Whitney\n              <jats:italic>U<\/jats:italic>\n              test, patients in the high-grade rejection group (11 patients) had a thicker intima in all coronary segments (distal: 0.22 mm [0.09\u20130.41] versus 0.09 mm [0.06\u20130.17],\n              <jats:italic>P<\/jats:italic>\n              =0.02; middle: 0.35 mm [0.00\u20130.45] versus 0.14 mm [0.08\u20130.24],\n              <jats:italic>P<\/jats:italic>\n              =0.002; and proximal: 0.34 mm [0.21\u20130.44] versus 0.15 mm [0.11\u20130.21],\n              <jats:italic>P<\/jats:italic>\n              =0.005) and a higher prevalence of foamy macrophages (distal: 55% versus 9%,\n              <jats:italic>P<\/jats:italic>\n              =0.003; middle: 55% versus 22%,\n              <jats:italic>P<\/jats:italic>\n              =0.004; and proximal: 44% versus 13%,\n              <jats:italic>P<\/jats:italic>\n              =0.05) using \u03c7\n              <jats:sup>2<\/jats:sup>\n              statistics. Side branches in the high-grade rejection group had smaller lumen diameters and a higher prevalence of intimal thickening (54% versus 36%;\n              <jats:italic>P<\/jats:italic>\n              =0.01). Intimal microvessels were also more prevalent in the high-grade rejection group versus the none\/mild rejection group (46% versus 11%;\n              <jats:italic>P<\/jats:italic>\n              =0.02).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Coronary optical coherence tomographic evaluation revealed that patients with a history of high-grade cellular rejection, compared with those with none\/mild rejection, had more coronary artery intimal thickening with macrophage infiltration, involving all coronary segments and side branches.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01403142.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.113.000949","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T05:09:27Z","timestamp":1397020167000},"page":"199-206","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Optical Coherence Tomographic Evaluation of Transplant Coronary Artery Vasculopathy With Correlation to Cellular Rejection"],"prefix":"10.1161","volume":"7","author":[{"given":"Liang","family":"Dong","sequence":"first","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Maehara","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamim M.","family":"Nazif","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari T.","family":"Pollack","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Saito","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LeRoy E.","family":"Rabbani","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Apfelbaum","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Dalton","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Moses","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich P.","family":"Jorde","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Mintz","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Mancini","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giora","family":"Weisz","sequence":"additional","affiliation":[{"name":"From the NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY (L.D., A.M., T.M.N., A.T.P., S.S., L.E.R., M.A.A., K.D., J.W.M., U.P.J., D.M.M., G.W.); the Cardiovascular Research Foundation, New York, NY (L.D., A.M., S.S., J.W.M., K.X., G.S.M., G.W.); The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China (L.D.); and Shaare Zedek Medical Center, Jerusalem, Israel (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.08.004"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.03.001"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.03.020"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.03.019"},{"key":"e_1_3_3_6_2","first-page":"757","volume-title":"Textbook of Interventional Cardiology","author":"Pompa J","year":"2011","unstructured":"Pompa J, Almonacid A, Burke D. 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