{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:47:37Z","timestamp":1785246457257,"version":"3.55.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Late adverse events such as very late stent thrombosis (VLST) or late target-lesion revascularization (TLR) after first-generation sirolimus-eluting stents (SES) implantation have not been yet fully characterized at long term in comparison with those after bare-metal stent (BMS) implantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Among 13\u2009058 consecutive patients undergoing first percutaneous coronary intervention in the Coronary REvascularization Demonstrating Outcome study-Kyoto registry Cohort-2, 5078 patients were treated with SES only, and 5392 patients were treated with BMS only. During 7-year follow-up, VLST and late TLR beyond 1 year after SES implantation occurred constantly and without attenuation at 0.24% per year and at 2.0% per year, respectively. Cumulative 7-year incidence of VLST was significantly higher in the SES group than that in the BMS group (1.43% versus 0.68%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). However, there was no excess of all-cause death beyond 1 year in the SES group as compared with that in the BMS group (20.8% versus 19.6%,\n              <jats:italic>P<\/jats:italic>\n              =0.91). Cumulative incidences of late TLR (both overall and clinically driven) were also significantly higher in the SES group than in the BMS group (12.0% versus 4.1%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001 and 8.5% versus 2.6%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001, respectively), leading to late catch-up of the SES group to the BMS group regarding TLR through the entire 7-year follow-up (18.8% versus 25.2%, and 10.6% versus 10.2%, respectively). Clinical presentation as acute coronary syndrome was more common at the time of late SES TLR compared with early SES TLR (21.2% and 10.0%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Late catch-up phenomenon regarding stent thrombosis and TLR was significantly more pronounced with SES than that with BMS. This limitation should remain the target for improvements of DES technology.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.113.000987","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T05:38:28Z","timestamp":1392788308000},"page":"168-179","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Late Adverse Events After Implantation of Sirolimus-Eluting Stent and Bare-Metal Stent"],"prefix":"10.1161","volume":"7","author":[{"given":"Masahiro","family":"Natsuaki","sequence":"first","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Furukawa","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushige","family":"Kadota","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyohei","family":"Yamaji","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ando","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Shizuta","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Shiomi","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Tada","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Tazaki","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kato","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Hayano","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Abe","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tamura","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Shirotani","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Miki","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Matsuda","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Takahashi","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhisa","family":"Ishii","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Tanaka","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Aoyama","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Doi","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Hattori","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kato","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Suwa","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Takizawa","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Takatsu","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Shinoda","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Eizawa","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruki","family":"Takeda","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Dae","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moriaki","family":"Inoko","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Ogawa","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Hamasaki","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. Kita); Division of Cardiology, Tenri Hospital, Tenri, Japan (Y.N.); Division of Cardiology, Kurashiki..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Horie","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (M. Natsuaki, S. Shizuta, H.S., T. Tada, J.T., Y.K., M.H., T. Kimura); Division of Genera Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan (Y.F., T. 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