{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T22:31:40Z","timestamp":1787351500505,"version":"build-2736575974"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>No method is available to predict whether patients with patent ductus arteriosus (PDA) and severe pulmonary arterial hypertension (PAH) will show persistent postprocedural PAH (PP-PAH) after PDA closure. This study evaluated the usefulness of trial occlusion for predicting PP-PAH after transcatheter PDA closure in patients with severe PAH.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>Trial occlusion was performed in 137 patients (age \u226512 years) with PDA and severe PAH. All patients undergoing trial occlusion had a mean pulmonary artery pressure \u226545 mm Hg, pulmonary:systemic flow (Qp\/Qs) ratio &gt;1.5, and pulmonary:systemic resistance (Rp\/Rs) ratio &lt;0.7. A total of 135 patients (98%) showing stable hemodynamics during occlusion trial underwent successful device closure. Linear correlation analysis revealed weak or moderate relationships between the baseline and post-trial pulmonary artery pressures and pulmonary:systemic pressure (Pp\/Ps) ratios. Patients were followed up for 1 to 10 years (median: 5 years). PP-PAH (systolic pulmonary artery pressure &gt;50 mm Hg by Doppler echocardiography) was detected in 17 patients (13%), who displayed no significant differences in sex and age compared with patients without PP-PAH. According to discriminant analysis, the strongest discriminators between patients with and without PP-PAH were the baseline left ventricular end-diastolic volume and the baseline and post-trial systolic Pp\/Ps ratios. In particular, a post-trial systolic Pp\/Ps ratio &gt;0.5 correctly classified 100% of the PP-PAH and non-PAH patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Trial occlusion is a feasible method to predict PP-PAH in patients with PDA and severe PAH. A post-trial systolic Pp\/Ps ratio &gt;0.5 indicates a high risk of PP-PAH occurrence after device closure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.113.001135","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T02:59:28Z","timestamp":1407293968000},"page":"473-481","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Trial Occlusion to Assess the Risk of Persistent Pulmonary Arterial Hypertension After Closure of a Large Patent Ductus Arteriosus in Adolescents and Adults With Elevated Pulmonary Artery Pressure"],"prefix":"10.1161","volume":"7","author":[{"given":"Duan-zhen","family":"Zhang","sequence":"first","affiliation":[{"name":"From the Department of Congenital Heart Disease, General Hospital of Shenyang Military Area Command, Shenyang, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-yang","family":"Zhu","sequence":"additional","affiliation":[{"name":"From the Department of Congenital Heart Disease, General Hospital of Shenyang Military Area Command, Shenyang, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Lv","sequence":"additional","affiliation":[{"name":"From the Department of Congenital Heart Disease, General Hospital of Shenyang Military Area Command, Shenyang, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-sheng","family":"Cui","sequence":"additional","affiliation":[{"name":"From the Department of Congenital Heart Disease, General Hospital of Shenyang Military Area Command, Shenyang, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-min","family":"Han","sequence":"additional","affiliation":[{"name":"From the Department of Congenital Heart Disease, General Hospital of Shenyang Military Area Command, Shenyang, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-tang","family":"Sheng","sequence":"additional","affiliation":[{"name":"From the Department of Congenital Heart Disease, General Hospital of Shenyang Military Area Command, Shenyang, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-guang","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Congenital Heart Disease, General Hospital of Shenyang Military Area Command, Shenyang, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Department of Congenital Heart Disease, General Hospital of Shenyang Military Area Command, Shenyang, People\u2019s Republic of China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2861"},{"key":"e_1_3_2_3_2","first-page":"860","article-title":"Atrial septal defect with severe pulmonary hypertension in elderly patients: usefulness of transient balloon occlusion.","volume":"63","author":"S\u00e1nchez-Recalde A","year":"2010","unstructured":"S\u00e1nchez-Recalde A, Oliver JM, Galeote G, Gonz\u00e1lez A, Calvo L, Jim\u00e9nez-Valero S, Moreno R, L\u00f3pez-Send\u00f3n JL. 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