{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:52:22Z","timestamp":1789095142471,"version":"build-2803163510"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Data are needed on the safety and efficacy of device closure of large atrial septal defects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Between 1998 and 2013, 336 patients (161 children &lt;15 years) with large, isolated, secundum atrial septal defects (balloon-stretched diameter \u226534 mm in adults or echocardiographic diameter &gt;15 mm\/m\n              <jats:sup>2<\/jats:sup>\n              in children) were managed using the Amplatzer device, at the Marie Lannelongue Hospital. Transthoracic echocardiographic guidance was used starting in 2005 (n=219; 65.2%). Balloon-stretched diameter was &gt;40 mm in 36 adults; mean values were 37.6\u00b13.3 mm in other adults and 26.3\u00b16.3 mm\/m\n              <jats:sup>2<\/jats:sup>\n              in children. Amplatzer closure was successful in 311 (92.6%; 95% confidence interval, 89%\u201395%) patients. Superior and posterior rim deficiencies were more common in failed than in successful procedures (superior, 24.0% versus 4.8%;\n              <jats:italic>P<\/jats:italic>\n              =0.002; and posterior, 32.0% versus 4.2%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Device migration occurred in 4 adults (2 cases each of surgical and transcatheter retrieval); in the 21 remaining failures, the device was unreleased and withdrawn. After a median follow-up of 10.0 years (2.5\u201317 years), all patients were alive with no history of late complications.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Closure of large atrial septal defects using the Amplatzer device is safe and effective in both adults and children. Superior and posterior rim deficiencies are associated with procedural failure. Closure can be performed under transthoracic echocardiographic guidance in experienced centers. Early device migration is rare and can be safely managed by device extraction. Long-term follow-up showed no deaths or major late complications in our population of 311 patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.113.001254","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T04:46:39Z","timestamp":1416977199000},"page":"837-843","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Transcatheter Closure of Large Atrial Septal Defects"],"prefix":"10.1161","volume":"7","author":[{"given":"Alban-Elouen","family":"Baruteau","sequence":"first","affiliation":[{"name":"From the Marie Lannelongue Hospital-M3C, Department of Pediatric Cardiac Surgery, Paris, France (A.-E.B., J.P., V.L., M.G., D.P., P.B., C.-Y.A., L.H., E.L.B., R.R., M.L., E.B.); Universit\u00e9 Paris Sud, Le Kremlin Bic\u00eatre, Paris, France (A.-E.B., A.C.); l\u2019Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1087, Centre National de la Recherche Scientifique (CNRS) 6291, Universit\u00e9 de Nantes, Nantes, France (A.-E.B.); and Institut National de la Sant\u00e9 et de la Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Petit","sequence":"additional","affiliation":[{"name":"From the Marie Lannelongue Hospital-M3C, Department of Pediatric Cardiac Surgery, Paris, France (A.-E.B., J.P., V.L., M.G., D.P., P.B., C.-Y.A., L.H., E.L.B., R.R., M.L., E.B.); Universit\u00e9 Paris Sud, Le Kremlin Bic\u00eatre, Paris, France (A.-E.B., A.C.); l\u2019Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1087, Centre National de la Recherche Scientifique (CNRS) 6291, Universit\u00e9 de Nantes, Nantes, France (A.-E.B.); and Institut National de la Sant\u00e9 et de la Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Lambert","sequence":"additional","affiliation":[{"name":"From the Marie Lannelongue Hospital-M3C, Department of Pediatric Cardiac Surgery, Paris, France (A.-E.B., J.P., V.L., M.G., D.P., P.B., C.-Y.A., L.H., E.L.B., R.R., M.L., E.B.); Universit\u00e9 Paris Sud, Le Kremlin Bic\u00eatre, Paris, France (A.-E.B., A.C.); l\u2019Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1087, Centre National de la Recherche Scientifique (CNRS) 6291, Universit\u00e9 de Nantes, Nantes, France (A.-E.B.); and Institut National de la Sant\u00e9 et de la Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Gouton","sequence":"additional","affiliation":[{"name":"From the Marie Lannelongue Hospital-M3C, Department of Pediatric Cardiac Surgery, Paris, France (A.-E.B., J.P., V.L., M.G., D.P., P.B., C.-Y.A., L.H., E.L.B., R.R., M.L., E.B.); Universit\u00e9 Paris Sud, Le Kremlin Bic\u00eatre, Paris, France (A.-E.B., A.C.); l\u2019Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1087, Centre National de la Recherche Scientifique (CNRS) 6291, Universit\u00e9 de Nantes, Nantes, France (A.-E.B.); and Institut National de la Sant\u00e9 et de la Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Piot","sequence":"additional","affiliation":[{"name":"From the Marie Lannelongue Hospital-M3C, Department of Pediatric Cardiac Surgery, Paris, France (A.-E.B., J.P., V.L., M.G., D.P., P.B., C.-Y.A., L.H., E.L.B., R.R., M.L., E.B.); Universit\u00e9 Paris Sud, Le Kremlin Bic\u00eatre, Paris, France (A.-E.B., A.C.); l\u2019Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1087, Centre National de la Recherche Scientifique (CNRS) 6291, Universit\u00e9 de Nantes, Nantes, France (A.-E.B.); and Institut National de la Sant\u00e9 et de la Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Brenot","sequence":"additional","affiliation":[{"name":"From the Marie Lannelongue Hospital-M3C, Department of Pediatric Cardiac Surgery, Paris, France (A.-E.B., J.P., V.L., M.G., D.P., P.B., C.-Y.A., L.H., E.L.B., R.R., M.L., E.B.); Universit\u00e9 Paris Sud, Le Kremlin Bic\u00eatre, Paris, France (A.-E.B., A.C.); l\u2019Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1087, Centre National de la Recherche Scientifique (CNRS) 6291, Universit\u00e9 de Nantes, Nantes, France (A.-E.B.); and Institut National de la Sant\u00e9 et de la Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude-Yves","family":"Angel","sequence":"additional","affiliation":[{"name":"From the Marie Lannelongue Hospital-M3C, Department of Pediatric Cardiac Surgery, Paris, France (A.-E.B., J.P., V.L., M.G., D.P., P.B., C.-Y.A., L.H., E.L.B., R.R., M.L., E.B.); 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Universit\u00e9 Paris Sud, Le Kremlin Bic\u00eatre, Paris, France (A.-E.B., A.C.); l\u2019Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1087, Centre National de la Recherche Scientifique (CNRS) 6291, Universit\u00e9 de Nantes, Nantes, France (A.-E.B.); and Institut National de la Sant\u00e9 et de la Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gine","family":"Roussin","sequence":"additional","affiliation":[{"name":"From the Marie Lannelongue Hospital-M3C, Department of Pediatric Cardiac Surgery, Paris, France (A.-E.B., J.P., V.L., M.G., D.P., P.B., C.-Y.A., L.H., E.L.B., R.R., M.L., E.B.); Universit\u00e9 Paris Sud, Le Kremlin Bic\u00eatre, Paris, France (A.-E.B., A.C.); l\u2019Institut du Thorax, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 1087, Centre National de la Recherche Scientifique (CNRS) 6291, Universit\u00e9 de Nantes, Nantes, France (A.-E.B.); and Institut National de la Sant\u00e9 et de la Recherche..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamedou","family":"Ly","sequence":"additional","affiliation":[{"name":"From the Marie Lannelongue Hospital-M3C, Department of Pediatric Cardiac Surgery, Paris, France (A.-E.B., J.P., V.L., M.G., D.P., P.B., C.-Y.A., L.H., E.L.B., R.R., M.L., E.B.); 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