{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:53:17Z","timestamp":1790250797196,"version":"4.1.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Reinfarction after primary percutaneous coronary intervention in patients with ST-segment\u2013elevation myocardial infarction has negative consequences. Little is known about reinfarction after drug-eluting stents and bivalirudin anticoagulation. We, therefore, sought to determine the incidence, predictors, and implications of reinfarction after primary percutaneous coronary intervention in the contemporary era.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Outcomes were assessed in 3202 patients undergoing stent implantation for ST-segment\u2013elevation myocardial infarction in the Harmonizing Outcomes with RevascularIZatiON and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial. Independent predictors of reinfarction and mortality were identified by Cox proportional hazards modeling. The cumulative incidence of reinfarction was 1.8% at 30 days, 4.0% at 1 year, and 6.9% at 3 years. Definite stent thrombosis was responsible for 76.3% of reinfarctions occurring within 30 days and 52.0% of all reinfarctions within 3 years. Independent predictors of reinfarction were current smoking, Killip class \u22652, baseline thrombocytosis, multivessel disease, symptom onset-to-balloon time, and total stent length. Randomization to bivalirudin versus heparin plus a glycoprotein IIb\/IIIa inhibitor and use of drug-eluting versus bare metal stents were not significant predictors of reinfarction. Reinfarction was a powerful independent predictor of subsequent cardiac mortality (hazard ratio [95% confidence interval]=7.65 [4.47\u201313.09];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and all-cause mortality (hazard ratio [95% confidence interval]=2.88 [1.74\u20134.78];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Despite advances in pharmacotherapy and stents, reinfarction after primary percutaneous coronary intervention is not infrequent, in the contemporary era is most often attributable to stent thrombosis, and is strongly associated with subsequent cardiac and all-cause mortality. Further enhancements in drugs and devices to prevent reinfarction are needed to improve outcomes in high-risk patients with ST-segment\u2013elevation myocardial infarction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00433966.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.114.001360","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T02:37:34Z","timestamp":1403059054000},"page":"543-551","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":78,"title":["Incidence, Predictors, and Implications of Reinfarction After Primary Percutaneous Coronary Intervention in ST-Segment\u2013Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"7","author":[{"given":"Samantha G.","family":"Stone","sequence":"first","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Serrao","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew I.","family":"Tomey","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Witzenbichler","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Guagliumi","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Z.","family":"Peruga","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R.","family":"Brodie","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Dudek","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"M\u00f6ckel","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin J.","family":"Brener","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Dangas","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (S.G.S., R.M., S.J.B., G.D., G.W. Stone); Department of Cardiology, Columbia University Medical Center, New York, NY (G.W. Serrao, G.W. Stone); Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (R.M., M.I.T., G.D.); Department of Cardiology, Amper Kliniken AG, Dachau, Germany (B.W.); Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy (G.G.); Department of Cardiology,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.10.005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80395-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90003-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(91)90712-Q"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80043-9"},{"key":"e_1_3_3_7_2","first-page":"871","article-title":"Gruppo Italiano per lo Studio della Streptochi-nasi nell\u2019Infarto Miocardico (GISSI).","volume":"2","author":"Long-Term Effects of Intravenous Thrombolysis in Acute Myocardial Infarction: Final Report of the GISSI Study","year":"1987","unstructured":"Long-Term Effects of Intravenous Thrombolysis in Acute Myocardial Infarction: Final Report of the GISSI Study. 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