{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:21:49Z","timestamp":1790619709286,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Biodegradable polymers for release of antiproliferative drugs from drug-eluting stents aim to improve vascular healing. We assessed noninferiority of a novel ultrathin strut drug-eluting stent releasing sirolimus from a biodegradable polymer (Orsiro, O-SES) compared with the durable polymer Xience Prime everolimus-eluting stent (X-EES) in terms of the primary end point in-stent late lumen loss at 9 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              A total of 452 patients were randomly assigned 2:1 to treatment with O-SES (298 patients, 332 lesions) or X-EES (154 patients, 173 lesions) in a multicenter, noninferiority trial. The primary end point was in-stent late loss at 9 months. O-SES was noninferior to X-EES for the primary end point (0.10\u00b10.32 versus 0.11\u00b10.29 mm; difference=0.00063 mm; 95% confidence interval, \u22120.06 to 0.07;\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>noninferiority<\/jats:sub>\n              &lt;0.0001). Clinical outcome showed similar rates of target-lesion failure at 1 year (O-SES 6.5% versus X-EES 8.0%; hazard ratio=0.82; 95% confidence interval, 0.40\u20131.68; log-rank test:\n              <jats:italic>P<\/jats:italic>\n              =0.58) without cases of stent thrombosis. A subgroup of patients (n=55) underwent serial optical coherence tomography at 9 months, which demonstrated similar neointimal thickness among lesions allocated to O-SES and X-EES (0.10\u00b10.04 mm versus 0.11\u00b10.04 mm; \u22120.01 [\u22120.04, \u22120.01];\n              <jats:italic>P<\/jats:italic>\n              =0.37). Another subgroup of patients (n=56) underwent serial intravascular ultrasound at baseline and 9 months indicating a potential difference in neointimal area at follow-up (O-SES, 0.16\u00b10.33 mm\n              <jats:sup>2<\/jats:sup>\n              versus X-EES, 0.43\u00b10.56 mm\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.04).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Compared with durable polymer X-EES, novel biodegradable polymer\u2013based O-SES was found noninferior for the primary end point in-stent late lumen loss at 9 months. Clinical event rates were comparable without cases of stent thrombosis throughout 1 year of follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01356888.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.114.001441","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T04:10:37Z","timestamp":1422591037000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":177,"title":["Comparison of a Novel Biodegradable Polymer Sirolimus-Eluting Stent With a Durable Polymer Everolimus-Eluting Stent"],"prefix":"10.1161","volume":"8","author":[{"given":"Stephan","family":"Windecker","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (S.W.); St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss, Germany (M.H.); Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Charit\u00e9-Campus Mitte, Berlin, Germany (K.S.); Charit\u00e9 Campus Benjamin Franklin, Berlin, Germany (B.W.); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (T.S.); Hospital Cl\u00ednic, Thorax Institute, Barcelona, Spain (M.S.); IDIBAPS, University of Barcelona,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Haude","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (S.W.); St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss, Germany (M.H.); Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Charit\u00e9-Campus Mitte, Berlin, Germany (K.S.); Charit\u00e9 Campus Benjamin Franklin, Berlin, Germany (B.W.); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (T.S.); Hospital Cl\u00ednic, Thorax Institute, Barcelona, Spain (M.S.); IDIBAPS, University of Barcelona,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz-Josef","family":"Neumann","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (S.W.); St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss, Germany (M.H.); Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Charit\u00e9-Campus Mitte, Berlin, Germany (K.S.); Charit\u00e9 Campus Benjamin Franklin, Berlin, Germany (B.W.); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (T.S.); Hospital Cl\u00ednic, Thorax Institute, Barcelona, Spain (M.S.); IDIBAPS, University of Barcelona,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Stangl","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (S.W.); St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss, Germany (M.H.); Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Charit\u00e9-Campus Mitte, Berlin, Germany (K.S.); Charit\u00e9 Campus Benjamin Franklin, Berlin, Germany (B.W.); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (T.S.); Hospital Cl\u00ednic, Thorax Institute, Barcelona, Spain (M.S.); IDIBAPS, University of Barcelona,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Witzenbichler","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (S.W.); St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss, Germany (M.H.); Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Charit\u00e9-Campus Mitte, Berlin, Germany (K.S.); Charit\u00e9 Campus Benjamin Franklin, Berlin, Germany (B.W.); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (T.S.); Hospital Cl\u00ednic, Thorax Institute, Barcelona, Spain (M.S.); IDIBAPS, University of Barcelona,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ton","family":"Slagboom","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (S.W.); St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss, Germany (M.H.); Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Charit\u00e9-Campus Mitte, Berlin, Germany (K.S.); Charit\u00e9 Campus Benjamin Franklin, Berlin, Germany (B.W.); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (T.S.); Hospital Cl\u00ednic, Thorax Institute, Barcelona, Spain (M.S.); IDIBAPS, University of Barcelona,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Sabat\u00e9","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (S.W.); St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss, Germany (M.H.); Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Charit\u00e9-Campus Mitte, Berlin, Germany (K.S.); Charit\u00e9 Campus Benjamin Franklin, Berlin, Germany (B.W.); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (T.S.); Hospital Cl\u00ednic, Thorax Institute, Barcelona, Spain (M.S.); IDIBAPS, University of Barcelona,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Goicolea","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (S.W.); St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss, Germany (M.H.); Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Charit\u00e9-Campus Mitte, Berlin, Germany (K.S.); Charit\u00e9 Campus Benjamin Franklin, Berlin, Germany (B.W.); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (T.S.); Hospital Cl\u00ednic, Thorax Institute, Barcelona, Spain (M.S.); IDIBAPS, University of Barcelona,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Barragan","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (S.W.); St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss, Germany (M.H.); Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Charit\u00e9-Campus Mitte, Berlin, Germany (K.S.); Charit\u00e9 Campus Benjamin Franklin, Berlin, Germany (B.W.); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (T.S.); Hospital Cl\u00ednic, Thorax Institute, Barcelona, Spain (M.S.); IDIBAPS, University of Barcelona,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Cook","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (S.W.); St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss, Germany (M.H.); Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Charit\u00e9-Campus Mitte, Berlin, Germany (K.S.); Charit\u00e9 Campus Benjamin Franklin, Berlin, Germany (B.W.); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (T.S.); 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St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss, Germany (M.H.); Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Charit\u00e9-Campus Mitte, Berlin, Germany (K.S.); Charit\u00e9 Campus Benjamin Franklin, Berlin, Germany (B.W.); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (T.S.); Hospital Cl\u00ednic, Thorax Institute, Barcelona, Spain (M.S.); IDIBAPS, University of Barcelona,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9la","family":"Merkely","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (S.W.); St\u00e4dtische Kliniken Neuss, Lukaskrankenhaus GmbH, Neuss, Germany (M.H.); Universit\u00e4ts-Herzzentrum Freiburg\u2013Bad Krozingen, Bad Krozingen, Germany (F.-J.N.); Charit\u00e9-Campus Mitte, Berlin, Germany (K.S.); Charit\u00e9 Campus Benjamin Franklin, Berlin, Germany (B.W.); Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (T.S.); 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