{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T04:56:38Z","timestamp":1794286598686,"version":"4.9.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Lipid-rich inflamed coronary plaques are prone to rupture. The purpose of this study was to assess lipid-rich inflamed plaques in vivo using fully integrated high-speed optical coherence tomography (OCT)\/near-infrared fluorescence (NIRF) molecular imaging with a Food and Drug Administration\u2013approved indocyanine green (ICG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      An integrated high-speed intravascular OCT\/NIRF imaging catheter and a dual-modal OCT\/NIRF system were constructed based on a clinical OCT platform. For imaging lipid-rich inflamed plaques, the Food and Drug Administration\u2013approved NIRF-emitting ICG (2.25 mg\/kg) or saline was injected intravenously into rabbit models with experimental atheromata induced by balloon injury and 12- to 14-week high-cholesterol diets. Twenty minutes after injection, in vivo OCT\/NIRF imaging of the infrarenal aorta and iliac arteries was acquired only under contrast flushing through catheter (pullback speed up to \u226420 mm\/s). NIRF signals were strongly detected in the OCT-visualized atheromata of the ICG-injected rabbits. The in vivo NIRF target-to-background ratio was significantly larger in the ICG-injected rabbits than in the saline-injected controls (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01). Ex vivo peak plaque target-to-background ratios were significantly higher in ICG-injected rabbits than in controls (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) on fluorescence reflectance imaging, which correlated well with the in vivo target-to-background ratios (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01;\n                      <jats:italic>r<\/jats:italic>\n                      =0.85) without significant bias (0.41). Cellular ICG uptake, correlative fluorescence microscopy, and histopathology also corroborated the in vivo imaging findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Integrated OCT\/NIRF structural\/molecular imaging with a Food and Drug Administration \u2013approved ICG accurately identified lipid-rich inflamed atheromata in coronary-sized vessels. This highly translatable dual-modal imaging approach could enhance our capabilities to detect high-risk coronary plaques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.114.001498","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T01:15:51Z","timestamp":1406682951000},"page":"560-569","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":94,"title":["Fully Integrated High-Speed Intravascular Optical Coherence Tomography\/Near-Infrared Fluorescence Structural\/Molecular Imaging In Vivo Using a Clinically Available Near-Infrared Fluorescence\u2013Emitting Indocyanine Green to Detect Inflamed Lipid-Rich Atheromata in Coronary-Sized Vessels"],"prefix":"10.1161","volume":"7","author":[{"given":"Sunki","family":"Lee","sequence":"first","affiliation":[{"name":"From the Multimodal Imaging and Theranostic Lab, Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea (S.L., J.W.S., D.J.O., J.W.K.); Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea (M.W.L., H.S.N., H.Y.); Department of Mechanical Engineering, KAIST, Daejeon, Republic of Korea (H.S.C., W.-Y.O.); and Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, Republic of Korea (K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Multimodal Imaging and Theranostic Lab, Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea (S.L., J.W.S., D.J.O., J.W.K.); Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea (M.W.L., H.S.N., H.Y.); Department of Mechanical Engineering, KAIST, Daejeon, Republic of Korea (H.S.C., W.-Y.O.); and Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, Republic of Korea (K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Saem","family":"Cho","sequence":"additional","affiliation":[{"name":"From the Multimodal Imaging and Theranostic Lab, Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea (S.L., J.W.S., D.J.O., J.W.K.); Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea (M.W.L., H.S.N., H.Y.); Department of Mechanical Engineering, KAIST, Daejeon, Republic of Korea (H.S.C., W.-Y.O.); and Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, Republic of Korea (K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Woo","family":"Song","sequence":"additional","affiliation":[{"name":"From the Multimodal Imaging and Theranostic Lab, Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea (S.L., J.W.S., D.J.O., J.W.K.); Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea (M.W.L., H.S.N., H.Y.); Department of Mechanical Engineering, KAIST, Daejeon, Republic of Korea (H.S.C., W.-Y.O.); and Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, Republic of Korea (K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong Soo","family":"Nam","sequence":"additional","affiliation":[{"name":"From the Multimodal Imaging and Theranostic Lab, Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea (S.L., J.W.S., D.J.O., J.W.K.); Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea (M.W.L., H.S.N., H.Y.); Department of Mechanical Engineering, KAIST, Daejeon, Republic of Korea (H.S.C., W.-Y.O.); and Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, Republic of Korea (K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Joo","family":"Oh","sequence":"additional","affiliation":[{"name":"From the Multimodal Imaging and Theranostic Lab, Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea (S.L., J.W.S., D.J.O., J.W.K.); Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea (M.W.L., H.S.N., H.Y.); Department of Mechanical Engineering, KAIST, Daejeon, Republic of Korea (H.S.C., W.-Y.O.); and Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, Republic of Korea (K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeongsoon","family":"Park","sequence":"additional","affiliation":[{"name":"From the Multimodal Imaging and Theranostic Lab, Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea (S.L., J.W.S., D.J.O., J.W.K.); Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea (M.W.L., H.S.N., H.Y.); Department of Mechanical Engineering, KAIST, Daejeon, Republic of Korea (H.S.C., W.-Y.O.); and Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, Republic of Korea (K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Yuhl","family":"Oh","sequence":"additional","affiliation":[{"name":"From the Multimodal Imaging and Theranostic Lab, Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea (S.L., J.W.S., D.J.O., J.W.K.); Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea (M.W.L., H.S.N., H.Y.); Department of Mechanical Engineering, KAIST, Daejeon, Republic of Korea (H.S.C., W.-Y.O.); and Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, Republic of Korea (K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongki","family":"Yoo","sequence":"additional","affiliation":[{"name":"From the Multimodal Imaging and Theranostic Lab, Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea (S.L., J.W.S., D.J.O., J.W.K.); Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea (M.W.L., H.S.N., H.Y.); Department of Mechanical Engineering, KAIST, Daejeon, Republic of Korea (H.S.C., W.-Y.O.); and Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, Republic of Korea (K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Won","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Multimodal Imaging and Theranostic Lab, Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea (S.L., J.W.S., D.J.O., J.W.K.); Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea (M.W.L., H.S.N., H.Y.); Department of Mechanical Engineering, KAIST, Daejeon, Republic of Korea (H.S.C., W.-Y.O.); and Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, Republic of Korea (K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90356-7"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.055616"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.036"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000017860.20619.23"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.785881"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2555"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01563-4"},{"key":"e_1_3_4_10_2","first-page":"1286","article-title":"Binding properties of indocyanine green in human blood.","volume":"39","author":"Yoneya S","year":"1998","unstructured":"Yoneya S, Saito T, Komatsu Y, Koyama I, Takahashi K, Duvoll-Young J. 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