{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:09:14Z","timestamp":1754482154497,"version":"3.41.2"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Intact or highly restricted intra-atrial septum can be reliably diagnosed in the human fetus as early as 22 to 24 weeks of gestation. Fetal interventions targeting the atrial septum have used a direct approach through the atrial wall. Here, we report stenting of the foramen ovale with a large, open-cell stent via percutaneous access through the fetal hepatic vein in a sheep model.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>In 5 fetal sheep of 109 to 111 days of gestation (term, 147 days), the fetal hepatic vein was punctured percutaneously under ultrasound guidance and a 13.3-cm 14-gauge intravenous catheter was inserted. After catheterization of the inferior vena cava, right atrium, foramen ovale, and left atrium with a guidewire and 1.8F to 2.6F tapered catheter, a self-expandable, 8\u00d712-mm flexible open-cell stent was positioned in an unrestricted foramen ovale. Flow and fetal well-being were documented for 45 minutes after the procedure. Access to the left atrium was achieved in all 5 animals and all survived. In 4 animals, the stent was successfully positioned in the foramen ovale. One fetus was born at term and euthanized on day 3: postmortem examination confirmed the patency of the stent. The other 3 fetuses were well after being monitored by ultrasound for 45 minutes. In 1 animal, the stent dislodged immediately after release obstructing the mitral valve. This fetus developed ascites and was euthanized after 4 days.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>It is feasible to safely advance a large diameter, self-expandable, open-cell design stent into the fetal atrial septum via a percutaneous access route through the fetal hepatic vein.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.114.001967","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T08:43:37Z","timestamp":1424940217000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Percutaneous Fetal Cardiac Catheterization Technique for Stenting the Foramen Ovale in a Midgestation Lamb Model"],"prefix":"10.1161","volume":"8","author":[{"given":"Andrew","family":"Edwards","sequence":"first","affiliation":[{"name":"From The Ritchie Centre, MIMR-PHI Institute of Medical Research, Monash University, Melbourne, Victoria, Australia (A.E., A.V., I.N., N.B., S.M., F.Y.W.); Perinatal Services (A.E., M.T., S.M.), Fetal Cardiac Unit (A.E., M.T., S.M.), Department of Pathology (Y.C.), and Monash Newborn (F.Y.W.), Monash Medical Centre, Melbourne, Victoria, Australia; Department of Paediatrics, Monash University, Melbourne, Victoria, Australia (A.V., F.Y.W.); and Pediatric Heart Center, Justus-Liebig University, Giessen,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Veldman","sequence":"additional","affiliation":[{"name":"From The Ritchie Centre, MIMR-PHI Institute of Medical Research, Monash University, Melbourne, Victoria, Australia (A.E., A.V., I.N., N.B., S.M., F.Y.W.); Perinatal Services (A.E., M.T., S.M.), Fetal Cardiac Unit (A.E., M.T., S.M.), Department of Pathology (Y.C.), and Monash Newborn (F.Y.W.), Monash Medical Centre, Melbourne, Victoria, Australia; Department of Paediatrics, Monash University, Melbourne, Victoria, Australia (A.V., F.Y.W.); and Pediatric Heart Center, Justus-Liebig University, Giessen,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias","family":"Nitsos","sequence":"additional","affiliation":[{"name":"From The Ritchie Centre, MIMR-PHI Institute of Medical Research, Monash University, Melbourne, Victoria, Australia (A.E., A.V., I.N., N.B., S.M., F.Y.W.); Perinatal Services (A.E., M.T., S.M.), Fetal Cardiac Unit (A.E., M.T., S.M.), Department of Pathology (Y.C.), and Monash Newborn (F.Y.W.), Monash Medical Centre, Melbourne, Victoria, Australia; Department of Paediatrics, Monash University, Melbourne, Victoria, Australia (A.V., F.Y.W.); and Pediatric Heart Center, Justus-Liebig University, Giessen,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuen","family":"Chan","sequence":"additional","affiliation":[{"name":"From The Ritchie Centre, MIMR-PHI Institute of Medical Research, Monash University, Melbourne, Victoria, Australia (A.E., A.V., I.N., N.B., S.M., F.Y.W.); Perinatal Services (A.E., M.T., S.M.), Fetal Cardiac Unit (A.E., M.T., S.M.), Department of Pathology (Y.C.), and Monash Newborn (F.Y.W.), Monash Medical Centre, Melbourne, Victoria, Australia; Department of Paediatrics, Monash University, Melbourne, Victoria, Australia (A.V., F.Y.W.); and Pediatric Heart Center, Justus-Liebig University, Giessen,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Brew","sequence":"additional","affiliation":[{"name":"From The Ritchie Centre, MIMR-PHI Institute of Medical Research, Monash University, Melbourne, Victoria, Australia (A.E., A.V., I.N., N.B., S.M., F.Y.W.); Perinatal Services (A.E., M.T., S.M.), Fetal Cardiac Unit (A.E., M.T., S.M.), Department of Pathology (Y.C.), and Monash Newborn (F.Y.W.), Monash Medical Centre, Melbourne, Victoria, Australia; Department of Paediatrics, Monash University, Melbourne, Victoria, Australia (A.V., F.Y.W.); and Pediatric Heart Center, Justus-Liebig University, Giessen,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Teoh","sequence":"additional","affiliation":[{"name":"From The Ritchie Centre, MIMR-PHI Institute of Medical Research, Monash University, Melbourne, Victoria, Australia (A.E., A.V., I.N., N.B., S.M., F.Y.W.); Perinatal Services (A.E., M.T., S.M.), Fetal Cardiac Unit (A.E., M.T., S.M.), Department of Pathology (Y.C.), and Monash Newborn (F.Y.W.), Monash Medical Centre, Melbourne, Victoria, Australia; Department of Paediatrics, Monash University, Melbourne, Victoria, Australia (A.V., F.Y.W.); and Pediatric Heart Center, Justus-Liebig University, Giessen,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Menahem","sequence":"additional","affiliation":[{"name":"From The Ritchie Centre, MIMR-PHI Institute of Medical Research, Monash University, Melbourne, Victoria, Australia (A.E., A.V., I.N., N.B., S.M., F.Y.W.); Perinatal Services (A.E., M.T., S.M.), Fetal Cardiac Unit (A.E., M.T., S.M.), Department of Pathology (Y.C.), and Monash Newborn (F.Y.W.), Monash Medical Centre, Melbourne, Victoria, Australia; Department of Paediatrics, Monash University, Melbourne, Victoria, Australia (A.V., F.Y.W.); and Pediatric Heart Center, Justus-Liebig University, Giessen,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Schranz","sequence":"additional","affiliation":[{"name":"From The Ritchie Centre, MIMR-PHI Institute of Medical Research, Monash University, Melbourne, Victoria, Australia (A.E., A.V., I.N., N.B., S.M., F.Y.W.); Perinatal Services (A.E., M.T., S.M.), Fetal Cardiac Unit (A.E., M.T., S.M.), Department of Pathology (Y.C.), and Monash Newborn (F.Y.W.), Monash Medical Centre, Melbourne, Victoria, Australia; Department of Paediatrics, Monash University, Melbourne, Victoria, Australia (A.V., F.Y.W.); and Pediatric Heart Center, Justus-Liebig University, Giessen,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flora Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"From The Ritchie Centre, MIMR-PHI Institute of Medical Research, Monash University, Melbourne, Victoria, Australia (A.E., A.V., I.N., N.B., S.M., F.Y.W.); Perinatal Services (A.E., M.T., S.M.), Fetal Cardiac Unit (A.E., M.T., S.M.), Department of Pathology (Y.C.), and Monash Newborn (F.Y.W.), Monash Medical Centre, Melbourne, Victoria, Australia; Department of Paediatrics, Monash University, Melbourne, Victoria, Australia (A.V., F.Y.W.); and Pediatric Heart Center, Justus-Liebig University, Giessen,..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00225-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.08.636"},{"key":"e_1_3_4_4_2","first-page":"32","article-title":"Hypoplastic left heart syndrome with intact atrial septum: case report.","volume":"1","author":"Cester M","year":"2007","unstructured":"Cester M, Pascoli I, Garofano G, Surico N, Paternoster DM. 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