{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:10:01Z","timestamp":1789150201740,"version":"build-2803163510"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The use of fractional flow reserve (FFR) in acute coronary syndromes is controversial. The British Heart Foundation Fractional Flow Reserve Versus Angiography in Guiding Management to Optimize Outcomes in Non-ST-Elevation Myocardial Infarction (FAMOUS-NSTEMI) study (NCT01764334) has recently demonstrated the safety and feasibility of FFR measurement in patients with non\u2013ST-segment\u2013elevation myocardial infarction. We report the findings of the cardiac magnetic resonance (CMR) substudy to assess the diagnostic accuracy of FFR compared with 3.0-T stress CMR perfusion.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              One hundred six patients with non\u2013ST-segment\u2013elevation myocardial infarction who had been referred for early invasive management were included from 2 centers. FFR was measured in all major patent epicardial coronary arteries with a visual stenosis estimated at \u226530%, and if percutaneous coronary intervention was performed, an FFR assessment was repeated. Myocardial perfusion was assessed with stress perfusion CMR at 3 T. The mean age was 56.7\u00b19.8 years; 82.6% were men. Mean time from FFR evaluation to CMR was 6.1\u00b13.1 days. The mean\u00b1SD left ventricular ejection fraction was 58.2\u00b19.1%. Mean infarct size was 5.4\u00b17.1%, and mean troponin concentration was 5.2\u00b19.2 \u03bcg\/L. There were 34 fixed and 160 inducible perfusion defects. There was a negative correlation between the number of segments with a perfusion abnormality and FFR (\n              <jats:italic>r<\/jats:italic>\n              =\u22120.77;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). The overall sensitivity, specificity, positive predictive value, and negative predictive value for an FFR of \u22640.8 were 91.4%, 92.2%, 76%, and 97%, respectively. Diagnostic accuracy was 92%. The positive and negative predictive values of FFR for flow-limiting coronary artery disease (FFR\u22640.8) in patients with non\u2013ST-segment\u2013elevation myocardial infarction (n=21) who underwent perfusion CMR before invasive angiography were 92% and 93%, respectively. Receiver operating characteristic analysis indicated that the optimal cutoff value of FFR for demonstrating reversible ischemia on CMR was \u22640.805 (area under the receiver operating characteristic curve, 0.94 [0.9\u20130.99];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>FFR in patients with recent non\u2013ST-segment\u2013elevation myocardial infarction showed high concordance with myocardial perfusion in matched territories as revealed by 3.0-T stress perfusion CMR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT02073422.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.114.002207","type":"journal-article","created":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T02:19:48Z","timestamp":1439000388000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Assessment of Fractional Flow Reserve in Patients With Recent Non\u2013ST-Segment\u2013Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"8","author":[{"given":"Jamie","family":"Layland","sequence":"first","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuli","family":"Rauhalammi","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Watkins","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Ahmed","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McClure","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew M.Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Carrick","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Sood","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Petrie","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vannesa","family":"Teng Yue May","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Eteiba","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell","family":"Lindsay","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"McEntegart","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United 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Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom (A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Berry","sequence":"additional","affiliation":[{"name":"From the West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom (J.L., S.W., N.A., M.M.Y.L., D.C., A.O., M.C.P., H.E., M.L., M.M., K.G.O., C.B.); BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (J.L., S.R., N.A., J.M., D.C., V.T.Y.M., A.R., C.B.); and Hairmyres Hospital, Hairmyres, East Kilbride, United Kingdom 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