{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:05:36Z","timestamp":1792717536707,"version":"4.5.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Contrast-induced acute kidney injury (CI-AKI), defined as a serum creatinine increase \u22650.5 mg\/dL or \u226525% within 72 hours after contrast exposure, is a common complication of procedures requiring contrast media and is associated with increased short- and long-term morbidity and mortality. Few studies describe the effects of CI-AKI in a large-scale acute coronary syndrome population, and the relationship between CI-AKI and bleeding events has not been extensively explored. We sought to evaluate the impact of CI-AKI after percutaneous coronary intervention in patients presenting with acute coronary syndrome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We pooled patient-level data for 9512 patients from the percutaneous coronary intervention cohorts of the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) and Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) multicenter randomized trials. Patients were classified according to CI-AKI development, and cardiovascular outcomes at 30 days and 1 year were compared between groups. A total of 1212 patients (12.7%) developed CI-AKI. Patients with CI-AKI were older, with a more extensive comorbidity profile than without CI-AKI. Multivariable analysis confirmed several previously identified predictors of CI-AKI, including diabetes mellitus, contrast volume, age, and baseline hemoglobin. Mortality rates were significantly higher in the CI-AKI group at 30 days (4.9% versus 0.7%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and 1 year (9.8% versus 2.9%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), as were rates of 1-year myocardial infarction, definite\/probable stent thrombosis, target lesion revascularization, and major adverse cardiac events. Major bleeding (13.8% versus 5.4%; hazard ratio, 2.64; 95% confidence interval, 2.21\u20133.15;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) was also higher in patients with CI-AKI. After multivariable adjustment, results were unchanged.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>CI-AKI after percutaneous coronary intervention in patients presenting with acute coronary syndrome is independently associated with increased risk of short- and long-term ischemic and hemorrhagic events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifiers: NCT00433966 (HORIZONS-AMI) and ACUITY (NCT00093158).\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.114.002475","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T02:49:48Z","timestamp":1437533388000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":163,"title":["Impact of Contrast-Induced Acute Kidney Injury After Percutaneous Coronary Intervention on Short- and Long-Term Outcomes"],"prefix":"10.1161","volume":"8","author":[{"given":"Daniele","family":"Giacoppo","sequence":"first","affiliation":[{"name":"From the Icahn School of Medicine at Mount Sinai, New York (D.G., U.B., J.W., S.B., G.D.D., R.M.); NewYork-Presbyterian Hospital and the Columbia University Medical Center (M.V.M., A.J.K., P.G., G.W.S.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Cardiovascular Research Foundation, New York (G.D.D., A.J.K., K.X., S.J.B., P.G., G.W.S., R.M.); Rabin Medical Center, Petach Tikva, Israel (R.K.); New York Methodist Hospital, Brooklyn (S.J.B.); and H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh V.","family":"Madhavan","sequence":"additional","affiliation":[{"name":"From the Icahn School of Medicine at Mount Sinai, New York (D.G., U.B., J.W., S.B., G.D.D., R.M.); NewYork-Presbyterian Hospital and the Columbia University Medical Center (M.V.M., A.J.K., P.G., G.W.S.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Cardiovascular Research Foundation, New York (G.D.D., A.J.K., K.X., S.J.B., P.G., G.W.S., R.M.); Rabin Medical Center, Petach Tikva, Israel (R.K.); New York Methodist Hospital, Brooklyn (S.J.B.); and H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman","family":"Baber","sequence":"additional","affiliation":[{"name":"From the Icahn School of Medicine at Mount Sinai, New York (D.G., U.B., J.W., S.B., G.D.D., R.M.); NewYork-Presbyterian Hospital and the Columbia University Medical Center (M.V.M., A.J.K., P.G., G.W.S.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Cardiovascular Research Foundation, New York (G.D.D., A.J.K., K.X., S.J.B., P.G., G.W.S., R.M.); Rabin Medical Center, Petach Tikva, Israel (R.K.); New York Methodist Hospital, Brooklyn (S.J.B.); and H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine","family":"Warren","sequence":"additional","affiliation":[{"name":"From the Icahn School of Medicine at Mount Sinai, New York (D.G., U.B., J.W., S.B., G.D.D., R.M.); NewYork-Presbyterian Hospital and the Columbia University Medical Center (M.V.M., A.J.K., P.G., G.W.S.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Cardiovascular Research Foundation, New York (G.D.D., A.J.K., K.X., S.J.B., P.G., G.W.S., R.M.); Rabin Medical Center, Petach Tikva, Israel (R.K.); New York Methodist Hospital, Brooklyn (S.J.B.); and H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Bansilal","sequence":"additional","affiliation":[{"name":"From the Icahn School of Medicine at Mount Sinai, New York (D.G., U.B., J.W., S.B., G.D.D., R.M.); NewYork-Presbyterian Hospital and the Columbia University Medical Center (M.V.M., A.J.K., P.G., G.W.S.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Cardiovascular Research Foundation, New York (G.D.D., A.J.K., K.X., S.J.B., P.G., G.W.S., R.M.); Rabin Medical Center, Petach Tikva, Israel (R.K.); New York Methodist Hospital, Brooklyn (S.J.B.); and H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Witzenbichler","sequence":"additional","affiliation":[{"name":"From the Icahn School of Medicine at Mount Sinai, New York (D.G., U.B., J.W., S.B., G.D.D., R.M.); NewYork-Presbyterian Hospital and the Columbia University Medical Center (M.V.M., A.J.K., P.G., G.W.S.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Cardiovascular Research Foundation, New York (G.D.D., A.J.K., K.X., S.J.B., P.G., G.W.S., R.M.); Rabin Medical Center, Petach Tikva, Israel (R.K.); New York Methodist Hospital, Brooklyn (S.J.B.); and H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Dangas","sequence":"additional","affiliation":[{"name":"From the Icahn School of Medicine at Mount Sinai, New York (D.G., U.B., J.W., S.B., G.D.D., R.M.); NewYork-Presbyterian Hospital and the Columbia University Medical Center (M.V.M., A.J.K., P.G., G.W.S.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Cardiovascular Research Foundation, New York (G.D.D., A.J.K., K.X., S.J.B., P.G., G.W.S., R.M.); Rabin Medical Center, Petach Tikva, Israel (R.K.); New York Methodist Hospital, Brooklyn (S.J.B.); and H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay J.","family":"Kirtane","sequence":"additional","affiliation":[{"name":"From the Icahn School of Medicine at Mount Sinai, New York (D.G., U.B., J.W., S.B., G.D.D., R.M.); NewYork-Presbyterian Hospital and the Columbia University Medical Center (M.V.M., A.J.K., P.G., G.W.S.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Cardiovascular Research Foundation, New York (G.D.D., A.J.K., K.X., S.J.B., P.G., G.W.S., R.M.); Rabin Medical Center, Petach Tikva, Israel (R.K.); New York Methodist Hospital, Brooklyn (S.J.B.); and H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"From the Icahn School of Medicine at Mount Sinai, New York (D.G., U.B., J.W., S.B., G.D.D., R.M.); NewYork-Presbyterian Hospital and the Columbia University Medical Center (M.V.M., A.J.K., P.G., G.W.S.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Cardiovascular Research Foundation, New York (G.D.D., A.J.K., K.X., S.J.B., P.G., G.W.S., R.M.); Rabin Medical Center, Petach Tikva, Israel (R.K.); New York Methodist Hospital, Brooklyn (S.J.B.); and H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Kornowski","sequence":"additional","affiliation":[{"name":"From the Icahn School of Medicine at Mount Sinai, New York (D.G., U.B., J.W., S.B., G.D.D., R.M.); NewYork-Presbyterian Hospital and the Columbia University Medical Center (M.V.M., A.J.K., P.G., G.W.S.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Cardiovascular Research Foundation, New York (G.D.D., A.J.K., K.X., S.J.B., P.G., G.W.S., R.M.); Rabin Medical Center, Petach Tikva, Israel (R.K.); New York Methodist Hospital, Brooklyn (S.J.B.); and H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin J.","family":"Brener","sequence":"additional","affiliation":[{"name":"From the Icahn School of Medicine at Mount Sinai, New York (D.G., U.B., J.W., S.B., G.D.D., R.M.); NewYork-Presbyterian Hospital and the Columbia University Medical Center (M.V.M., A.J.K., P.G., G.W.S.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Cardiovascular Research Foundation, New York (G.D.D., A.J.K., K.X., S.J.B., P.G., G.W.S., R.M.); Rabin Medical Center, Petach Tikva, Israel (R.K.); New York Methodist Hospital, Brooklyn (S.J.B.); and H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"G\u00e9n\u00e9reux","sequence":"additional","affiliation":[{"name":"From the Icahn School of Medicine at Mount Sinai, New York (D.G., U.B., J.W., S.B., G.D.D., R.M.); NewYork-Presbyterian Hospital and the Columbia University Medical Center (M.V.M., A.J.K., P.G., G.W.S.); Helios Amper-Klinikum, Dachau, Germany (B.W.); Cardiovascular Research Foundation, New York (G.D.D., A.J.K., K.X., S.J.B., P.G., G.W.S., R.M.); Rabin Medical Center, Petach Tikva, Israel (R.K.); New York Methodist Hospital, Brooklyn (S.J.B.); 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