{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:07:26Z","timestamp":1765609646484},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The new balloon-expandable Sapien 3 transcatheter heart valve (S3-THV) incorporates new features to reduce aortic regurgitation (AR) and vascular complications in transcatheter aortic valve implantation. Aim of this study is to compare the outcomes of the S3-THV with the preceding Sapien XT THV (SXT-THV) in patients who underwent transcatheter aortic valve implantation for symptomatic severe native aortic stenosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Eligible patients were retrospectively identified in our institutional database and periprocedural clinical and imaging data were collected. Non-parsimonious one-to-many propensity score matching was performed to account for differences in baseline characteristics. Between November 2011 and December 2014, 167 patients underwent balloon-expandable transcatheter aortic valve implantation with either the S3-THV (n=49) or SXT-THV (n=118). Forty-four (89.8%) S3-THV patients were matched to 66 (55.9%) SXT-THV patients (mean age 80.3\u00b18.4 and 80.5\u00b17.8 years, median EuroSCORE 15.8 and 16.5%, respectively). In the S3-THV and SXT-THV groups, transfemoral approach (77.3% versus 78.8%) and postdilatation rates (15.9% versus 12.1%) were similar. Predischarge echocardiography demonstrated a lower incidence of \u2265mild AR (15.9% versus 46.2%,\n              <jats:italic>P<\/jats:italic>\n              =0.003) for the S3-THV, despite reduced annulus area to prosthesis oversizing (8.2\u00b15.1 versus 18.2\u00b110.7%,\n              <jats:italic>P<\/jats:italic>\n              =0.001). Transfemoral access site\u2013related life-threatening or major bleedings and vascular complications were absent in the S3-THV group (0% versus 7.7%,\n              <jats:italic>P<\/jats:italic>\n              =0.15). No differences were observed in pacemaker implantation rate (9.8% versus 8.8%,\n              <jats:italic>P<\/jats:italic>\n              =0.94) and 30-day mortality (both 5%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In this retrospective, propensity score\u2013matched analysis, the S3-THV performed superiorly to the SXT-THV, as demonstrated by improved valve patency and increased transfemoral access safety.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.115.002408","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T03:35:20Z","timestamp":1433216120000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Transcatheter Aortic Valve Implantation With the New Balloon-Expandable Sapien 3 Versus Sapien XT Valve System"],"prefix":"10.1161","volume":"8","author":[{"given":"Freek","family":"Nijhoff","sequence":"first","affiliation":[{"name":"From the Departments of Cardiology (F.N., M.A., P.A., P.A.D., P.R.S.) and Cardiothoracic Surgery (F.Z.R.), University Medical Center Utrecht, Utrecht, Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masieh","family":"Abawi","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (F.N., M.A., P.A., P.A.D., P.R.S.) and Cardiothoracic Surgery (F.Z.R.), University Medical Center Utrecht, Utrecht, Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierfrancesco","family":"Agostoni","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (F.N., M.A., P.A., P.A.D., P.R.S.) and Cardiothoracic Surgery (F.Z.R.), University Medical Center Utrecht, Utrecht, Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiz Z.","family":"Ramjankhan","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (F.N., M.A., P.A., P.A.D., P.R.S.) and Cardiothoracic Surgery (F.Z.R.), University Medical Center Utrecht, Utrecht, Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter A.","family":"Doevendans","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (F.N., M.A., P.A., P.A.D., P.R.S.) and Cardiothoracic Surgery (F.Z.R.), University Medical Center Utrecht, Utrecht, Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter R.","family":"Stella","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (F.N., M.A., P.A., P.A.D., P.R.S.) and Cardiothoracic Surgery (F.Z.R.), University Medical Center Utrecht, Utrecht, Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400590"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.022"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8SQA15"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.026"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jen303"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jet105"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.06.021"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs533"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(64)90027-X"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9I5A91"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.09.019"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1674"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3207"},{"key":"e_1_3_2_17_2","article-title":"A randomized evaluation of the SAPIEN XT transcatheter valve system in patients with aortic stenosis who are not candidates for surgery: Partner II, inoperable cohort.","author":"Leon MB.","year":"2013","unstructured":"Leon MB. 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