{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:25:59Z","timestamp":1769833559789,"version":"3.49.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>In-stent restenosis (ISR) remains a difficult problem in interventional cardiology. The relative efficacy and safety of available interventions is not clear. We aimed to perform a network meta-analysis using both direct evidence and indirect evidence to compare all available interventions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>We systematically searched electronic databases for randomized trials comparing \u22652 treatments for ISR. A network meta-analysis was performed using a Bayesian approach. Eleven treatments were compared in 31 studies with 8157 patient-years follow-up. Compared with balloon angioplasty, everolimus-eluting stent (hazard ratio [95% credibility interval], 0.13 [0.048\u20130.35]), paclitaxel-eluting balloon (0.32 [0.20\u20130.49]), paclitaxel-eluting cutting balloon (0.054 [0.0017\u20130.5]), paclitaxel-eluting stent (0.39 [0.24\u20130.62]), and sirolimus-eluting stent (0.32 [0.18\u20130.50]) are associated with lower target vessel revascularization. Balloon angioplasty is not different from cutting balloon (0.73 [0.31\u20131.5]), excimer laser (0.89 [0.29\u20132.7]), rotational atherectomy (0.96 [0.53\u20131.7]), and vascular brachytherapy (0.60 [0.35\u20131.0]). In drug-eluting stent ISR, balloon angioplasty was inferior to everolimus-eluting stent (0.19 [0.049\u20130.76]), paclitaxel-eluting balloon (0.43 [0.18\u20130.80]), paclitaxel-eluting stent (0.35 [0.13\u20130.76]), and sirolimus-eluting stent (0.36 [0.11\u20130.86]) for target vessel revascularization. There was no difference between treatments in probable or definitive stent thrombosis. The results of binary restenosis and target lesion revascularization were similar. Paclitaxel-eluting cutting balloon, everolimus-eluting stent, and paclitaxel-eluting balloon have the highest probability of being in the top 3 treatments based on low target lesion revascularization, but there was no statistical significant difference between them.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Balloon angioplasty is inferior to all drug-eluting treatments for ISR, including drug-eluting stent ISR. Drug-eluting stent, particularly everolimus-eluting stent, or paclitaxel-eluting cutting balloon and paclitaxel-eluting balloon should be preferred for treating ISR.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.115.002778","type":"journal-article","created":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T04:23:28Z","timestamp":1446870208000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Efficacy of Various Percutaneous Interventions for In-Stent Restenosis"],"prefix":"10.1161","volume":"8","author":[{"given":"Ankur","family":"Sethi","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Chicago Medical School at Rosalind Franklin University of Medicine, North Chicago, IL; and Division of Cardiology, Mount Sinai Hospital Medical Center, Chicago, IL."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurveen","family":"Malhotra","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Chicago Medical School at Rosalind Franklin University of Medicine, North Chicago, IL; and Division of Cardiology, Mount Sinai Hospital Medical Center, Chicago, IL."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhchain","family":"Singh","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Chicago Medical School at Rosalind Franklin University of Medicine, North Chicago, IL; and Division of Cardiology, Mount Sinai Hospital Medical Center, Chicago, IL."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Param P.","family":"Singh","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Chicago Medical School at Rosalind Franklin University of Medicine, North Chicago, IL; and Division of Cardiology, Mount Sinai Hospital Medical Center, Chicago, IL."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Khosla","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Chicago Medical School at Rosalind Franklin University of Medicine, North Chicago, IL; and Division of Cardiology, Mount Sinai Hospital Medical Center, Chicago, IL."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198703193161201"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408253310801"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.966"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61444-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.781377"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.111.967802"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu278"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2014.01.004"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1080\/10618600.1998.10474787","article-title":"General methods for monitoring convergence of iterative simulations.","volume":"7","author":"Brooks SP","year":"1998","unstructured":"Brooks SP, Gelman A. 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