{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:48:18Z","timestamp":1790718498718,"version":"4.1.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Cardiac troponin detected by new-generation, highly sensitive assays predicts clinical outcomes among patients with stable coronary artery disease (SCAD) treated medically. The prognostic value of baseline high-sensitivity cardiac troponin T (hs-cTnT) elevation in SCAD patients undergoing elective percutaneous coronary interventions is not well established. This study assessed the association of preprocedural levels of hs-cTnT with 1-year clinical outcomes among SCAD patients undergoing percutaneous coronary intervention.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Between 2010 and 2014, 6974 consecutive patients were prospectively enrolled in the Bern Percutaneous Coronary Interventions Registry. Among patients with SCAD (n=2029), 527 (26%) had elevated preprocedural hs-cTnT above the upper reference limit of 14 ng\/L. The primary end point, mortality within 1 year, occurred in 20 patients (1.4%) with normal hs-cTnT versus 39 patients (7.7%) with elevated baseline hs-cTnT (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Patients with elevated hs-cTnT had increased risks of all-cause (hazard ratio 5.73; 95% confidence intervals 3.34\u20139.83;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and cardiac mortality (hazard ratio 4.68; 95% confidence interval 2.12\u201310.31;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Preprocedural hs-TnT elevation remained an independent predictor of 1-year mortality after adjustment for relevant risk factors, including age, sex, and renal failure (adjusted hazard ratio 2.08; 95% confidence interval 1.10\u20133.92;\n              <jats:italic>P<\/jats:italic>\n              =0.024). A graded mortality risk was observed across higher tertiles of elevated preprocedural hs-cTnT, but not among patients with hs-cTnT below the upper reference limit.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Preprocedural elevation of hs-cTnT is observed in one fourth of SCAD patients undergoing elective percutaneous coronary intervention. Increased levels of preprocedural hs-cTnT are proportionally related to the risk of death and emerged as independent predictors of all-cause mortality within 1 year.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT02241291.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.115.003202","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T03:09:25Z","timestamp":1465873765000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Preprocedural High-Sensitivity Cardiac Troponin T and Clinical Outcomes in Patients With Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"9","author":[{"given":"Thomas","family":"Zanchin","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"R\u00e4ber","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos C.","family":"Koskinas","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Piccolo","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"J\u00fcni","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pilgrim","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Stortecky","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Khattab","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wenaweser","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bloechlinger","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Moschovitis","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Frenk","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Moro","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Meier","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg M.","family":"Fiedler","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dik","family":"Heg","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); Applied Health Research Centre, St Michael\u2019s Hospital, University of Toronto, Canada (P.J.); Center for Laboratory Medicine, Inselspital, University Hospital Bern, Switzerland (G.M.F.); and Institute of Social and Preventive Medicine, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland (T.Z., L.R., K.C.K., R.P., T.P., S.S., A.A.K., P.W., S.B., A.M., A.F., C.M., B.M., S.W.); 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