{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:49:19Z","timestamp":1784159359689,"version":"3.55.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The incidence and predictors of long-term mortality after percutaneous coronary intervention (PCI) for radiation-associated coronary artery disease are unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              In this observational study of 314 patients (age, 65.2\u00b111.4 years; 233 [74%] women) treated with PCI, 157 patients with previous external beam radiation therapy (XRT) were matched 1:1 with 157 comparison patients with atherosclerotic coronary artery disease without previous XRT, based on age, sex, lesion artery, and PCI type. The primary end point was all-cause mortality, and the secondary end point was cardiovascular mortality. After follow-up of 6.6\u00b15.5 years, there were 101 deaths; 59 in the XRT group and 42 in the comparison group (\n              <jats:italic>P<\/jats:italic>\n              =0.04). On Cox proportional hazards multivariable survival analysis, previous XRT remained an independent predictor of all-cause mortality (hazard ratio [HR] 1.85; 95% confidence interval [CI], 1.21\u20132.85;\n              <jats:italic>P<\/jats:italic>\n              =0.004) and cardiovascular mortality (HR, 1.70; 95% CI, 1.06\u20132.89;\n              <jats:italic>P<\/jats:italic>\n              =0.03). Additional independent predictors of increased all-cause mortality included balloon angioplasty or bare-metal stent placement compared with drug-eluting stent placement (HR, 2.50; 95% CI, 1.61\u20133.97;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), SYNTAX (Synergy Between PCI With Taxus and Cardiac Surgery) score of \u226511 (the sample median; HR, 1.99; 95% CI, 1.32\u20133.04;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), New York Heart Association functional class \u22653 (HR, 1.83; 95% CI, 1.15\u20132.91;\n              <jats:italic>P<\/jats:italic>\n              =0.012), history of smoking (HR, 1.88; 95% CI, 1.10\u20133.09;\n              <jats:italic>P<\/jats:italic>\n              =0.022), and age \u226565 years (HR, 1.70; 95% CI, 1.07\u20132.07;\n              <jats:italic>P<\/jats:italic>\n              =0.024).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Compared with patients with typical atherosclerotic coronary artery disease, patients with radiation-associated coronary artery disease are at higher risk for mortality after PCI. Previous XRT exposure is independently associated with increased all-cause and cardiovascular mortality in patients treated with PCI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.115.003483","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T03:11:18Z","timestamp":1466133078000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Long-Term Mortality in Patients With Radiation-Associated Coronary Artery Disease Treated With Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"9","author":[{"given":"Grant W.","family":"Reed","sequence":"first","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Center for Radiation Heart Disease, Cleveland Clinic, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Masri","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Center for Radiation Heart Disease, Cleveland Clinic, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P.","family":"Griffin","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Center for Radiation Heart Disease, Cleveland Clinic, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir R.","family":"Kapadia","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Center for Radiation Heart Disease, Cleveland Clinic, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Ellis","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Center for Radiation Heart Disease, Cleveland Clinic, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind Y.","family":"Desai","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Center for Radiation Heart Disease, Cleveland Clinic, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.090"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-013-0259-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.08.638"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510160067031"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.1180"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(03)00026-2"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001435"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.183129"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21109"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.05.035"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.4.1193"},{"key":"e_1_3_2_13_2","first-page":"219","article-title":"The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease.","volume":"1","author":"Sianos G","year":"2005","unstructured":"Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, van den Brand M, Van Dyck N, Russell ME, Mohr FW, Serruys PW. 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