{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:16:01Z","timestamp":1792001761961,"version":"4.4.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Available data on the clinical impact of new-onset left bundle branch block (LBBB) and permanent pacemaker implantation (PPI) after transcatheter aortic valve replacement (TAVR) remains controversial. We aimed to evaluate the impact of (1) periprocedural new-onset LBBB or PPI post-TAVR on cardiac mortality and all-cause 1-year mortality and (2) new-onset LBBB on the need for PPI at 1-year follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>We performed a systematic search from PubMed and EMBASE databases for studies reporting raw data on new-onset LBBB post-TAVR and the need for PPI or mortality at 1-year follow-up, or on 1-year mortality according to the need for periprocedural PPI post-TAVR. Data from 17 studies, including 4756 patients (8 studies) and 7032 patients (11 studies) for the evaluation of the impact of new-onset LBBB and periprocedural PPI post-TAVR were sourced, respectively (with 2 studies used for both outcomes). New-onset LBBB post-TAVR was associated with a higher risk of PPI (risk ratio [RR], 2.18; 95% confidence interval [CI], 1.28\u20133.70) and cardiac death (RR, 1.39; 95% CI, 1.04\u20131.86) during follow-up, as well with a tendency toward an increase in all-cause mortality (RR, 1.21; 95% CI, 0.98\u20131.50). Periprocedural PPI post-TAVR was not associated with any increased risk of all-cause mortality at 1 year (RR, 1.03; 95% CI, 0.9\u20131.18), yet a tendency toward a protective effect on cardiac death was observed (RR, 0.78; 95% CI, 0.60\u20131.03).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>New-onset LBBB post-TAVR is a marker of an increased risk of cardiac death and need for PPI at 1-year follow-up. The need for PPI early post-TAVR did not increase the risk of death.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.115.003635","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T04:43:43Z","timestamp":1463028223000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":266,"title":["Impact of New-Onset Left Bundle Branch Block and Periprocedural Permanent Pacemaker Implantation on Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"9","author":[{"given":"Ander","family":"Regueiro","sequence":"first","affiliation":[{"name":"From the Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (A.R., O.A.-J.A., M.d.T., F.C.-P., R.P., F.P., J.R.-C.); and Cardiology Department, Bichat-Claude Bernard Hospital, Paris, France (M.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Abdul-Jawad Altisent","sequence":"additional","affiliation":[{"name":"From the Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (A.R., O.A.-J.A., M.d.T., F.C.-P., R.P., F.P., J.R.-C.); and Cardiology Department, Bichat-Claude Bernard Hospital, Paris, France (M.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Del Trigo","sequence":"additional","affiliation":[{"name":"From the Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (A.R., O.A.-J.A., M.d.T., F.C.-P., R.P., F.P., J.R.-C.); and Cardiology Department, Bichat-Claude Bernard Hospital, Paris, France (M.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Campelo-Parada","sequence":"additional","affiliation":[{"name":"From the Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (A.R., O.A.-J.A., M.d.T., F.C.-P., R.P., F.P., J.R.-C.); and Cardiology Department, Bichat-Claude Bernard Hospital, Paris, France (M.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Puri","sequence":"additional","affiliation":[{"name":"From the Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (A.R., O.A.-J.A., M.d.T., F.C.-P., R.P., F.P., J.R.-C.); and Cardiology Department, Bichat-Claude Bernard Hospital, Paris, France (M.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Urena","sequence":"additional","affiliation":[{"name":"From the Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (A.R., O.A.-J.A., M.d.T., F.C.-P., R.P., F.P., J.R.-C.); and Cardiology Department, Bichat-Claude Bernard Hospital, Paris, France (M.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Philippon","sequence":"additional","affiliation":[{"name":"From the Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (A.R., O.A.-J.A., M.d.T., F.C.-P., R.P., F.P., J.R.-C.); and Cardiology Department, Bichat-Claude Bernard Hospital, Paris, France (M.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Rod\u00e9s-Cabau","sequence":"additional","affiliation":[{"name":"From the Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada (A.R., O.A.-J.A., M.d.T., F.C.-P., R.P., F.P., J.R.-C.); and Cardiology Department, Bichat-Claude Bernard Hospital, Paris, France (M.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.164"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht086"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV11SWA30"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.033"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.101055"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001099"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.07.022"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005479"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083138"},{"key":"e_1_3_3_11_2","author":"Higgins JPT","unstructured":"Higgins JPT, Green S, eds. 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