{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:48:33Z","timestamp":1761562113478,"version":"3.41.2"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The impact of vascular closure devices (VCDs) via the femoral arterial access site on short-term mortality in patients undergoing percutaneous coronary intervention is currently unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              The association between femoral arterial vascular access site management (manual pressure [including external clamp] versus VCD) and 30-day mortality was examined in a national real-world registry of 271 845 patients undergoing percutaneous coronary intervention for elective, non\u2013ST-segment\u2013elevation myocardial infarction and ST-segment\u2013elevation myocardial infarction indications in the United Kingdom between 2006 and 2011. Crude and propensity score\u2013corrected analyses were performed using Cox regression, with additional analyses undertaken in clinically relevant subgroups; 40.1% (n=109 001) of subjects were treated with manual pressure and 59.9% (n=162 844) with VCD. Subjects treated with VCD had fewer comorbidities and were less likely to present with ST-segment\u2013elevation myocardial infarction and cardiogenic shock (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Crude 30-day mortality was lower in the group treated with VCD compared with manual pressure (hazard ratio [HR], 0.58; 95% confidence interval [CI], 0.54\u20130.61; 1.4% versus 2.4%, log rank\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), findings that were substantially reduced but persisted after propensity score correction (HR, 0.91; 95% CI, 0.86\u20130.97; 1.8% versus 2.0% versus\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). A more pronounced association of VCD with a reduction in 30-day mortality was evident in females (HR, 0.85; 95% CI, 0.77\u20130.94;\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>interaction<\/jats:sub>\n              =0.037), presentation with acute coronary syndrome (HR, 0.88; 95% CI, 0.83\u20130.94;\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>interaction<\/jats:sub>\n              =0.0027), or recent lysis (HR, 0.63; 95% CI, 0.40\u20131.01;\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>interaction<\/jats:sub>\n              =0.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>When compared with manual pressure, VCD was associated with a minor short-term (30-day) prognostic benefit after propensity score correction in the global population and clinically relevant subgroups. The potential for residual confounding factors impacting on short-term mortality cannot be excluded, despite the study having measured and balanced all recorded confounder factors.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.116.003560","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T04:24:29Z","timestamp":1464236669000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Relationship Between Femoral Vascular Closure Devices and Short-Term Mortality From 271 845 Percutaneous Coronary Intervention Procedures Performed in the United Kingdom Between 2006 and 2011"],"prefix":"10.1161","volume":"9","author":[{"given":"Vasim","family":"Farooq","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Manchester Heart Centre, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Trust, Manchester, United Kingdom (V.F., D.G., M.E.-O.); Department of Cardiology, Queen Elizabeth Hospital, Birmingham, United Kingdom (P.L.); Department of Cardiology, The James Cook University Hospital, Middlesbrough, United Kingdom (M.A.d.B.); and Department of Cardiology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom (A.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Goedhart","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Manchester Heart Centre, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Trust, Manchester, United Kingdom (V.F., D.G., M.E.-O.); Department of Cardiology, Queen Elizabeth Hospital, Birmingham, United Kingdom (P.L.); Department of Cardiology, The James Cook University Hospital, Middlesbrough, United Kingdom (M.A.d.B.); and Department of Cardiology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom (A.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ludman","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Manchester Heart Centre, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Trust, Manchester, United Kingdom (V.F., D.G., M.E.-O.); Department of Cardiology, Queen Elizabeth Hospital, Birmingham, United Kingdom (P.L.); Department of Cardiology, The James Cook University Hospital, Middlesbrough, United Kingdom (M.A.d.B.); and Department of Cardiology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom (A.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"de Belder","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Manchester Heart Centre, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Trust, Manchester, United Kingdom (V.F., D.G., M.E.-O.); Department of Cardiology, Queen Elizabeth Hospital, Birmingham, United Kingdom (P.L.); Department of Cardiology, The James Cook University Hospital, Middlesbrough, United Kingdom (M.A.d.B.); and Department of Cardiology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom (A.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alun","family":"Harcombe","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Manchester Heart Centre, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Trust, Manchester, United Kingdom (V.F., D.G., M.E.-O.); Department of Cardiology, Queen Elizabeth Hospital, Birmingham, United Kingdom (P.L.); Department of Cardiology, The James Cook University Hospital, Middlesbrough, United Kingdom (M.A.d.B.); and Department of Cardiology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom (A.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdi","family":"El-Omar","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Manchester Heart Centre, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Trust, Manchester, United Kingdom (V.F., D.G., M.E.-O.); Department of Cardiology, Queen Elizabeth Hospital, Birmingham, United Kingdom (P.L.); Department of Cardiology, The James Cook University Hospital, Middlesbrough, United Kingdom (M.A.d.B.); and Department of Cardiology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom (A.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.027"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.612812"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm019"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.073"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.02.011"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.12.045"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.06.017"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.08.023"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.06.026"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.075"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300558"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.1651"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000536"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.10.032"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60292-6"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90529-A"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00101-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00882-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.10.032"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.3.350"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-002-1942-9"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25663"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.896704"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.860494"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01924-1"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10431"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.708"},{"key":"e_1_3_2_30_2","first-page":"328","article-title":"Bleeding and vascular complications at the femoral access site following percutaneous coronary intervention (PCI): an evaluation of hemostasis strategies.","volume":"24","author":"Tavris DR","year":"2012","unstructured":"Tavris DR, Wang Y, Jacobs S, Gallauresi B, Curtis J, Messenger J, Resnic FS, Fitzgerald S. Bleeding and vascular complications at the femoral access site following percutaneous coronary intervention (PCI): an evaluation of hemostasis strategies. J Invasive Cardiol. 2012;24:328\u2013334.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_2_31_2","first-page":"815","article-title":"Vascular occlusion as a late complication of the Angio-Seal closure device. A review of literature.","volume":"55","author":"Van Den Broek T","year":"2007","unstructured":"Van Den Broek T, Liqui Lung PF, Suttorp MJ, Eefting FD, Schipper ME, Vink A. Vascular occlusion as a late complication of the Angio-Seal closure device. A review of literature. Minerva Cardioangiol. 2007;55:815\u2013819.","journal-title":"Minerva Cardioangiol"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23151"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.001306"},{"key":"e_1_3_2_34_2","first-page":"175","article-title":"Vascular complications after percutaneous coronary intervention following hemostasis with the Mynx vascular closure device versus the AngioSeal vascular closure device.","volume":"22","author":"Azmoon S","year":"2010","unstructured":"Azmoon S, Pucillo AL, Aronow WS, Ebrahimi R, Vozzolo J, Rajdev A, Kalapatapu K, Ro JH, Hjemdahl-Monsen C. Vascular complications after percutaneous coronary intervention following hemostasis with the Mynx vascular closure device versus the AngioSeal vascular closure device. J Invasive Cardiol. 2010;22:175\u2013178.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01449-8"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.877407"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01453-X"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181f9b345"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300299"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19981015)17:19<2265::AID-SIM918>3.0.CO;2-B"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(82)90058-3"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.4710280508"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2007.07.010"},{"key":"e_1_3_2_44_2","first-page":"599","article-title":"Review of vascular closure devices.","volume":"22","author":"Schwartz BG","year":"2010","unstructured":"Schwartz BG, Burstein S, Economides C, Kloner RA, Shavelle DM, Mayeda GS. Review of vascular closure devices. J Invasive Cardiol. 2010;22:599\u2013607.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.048"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.108290"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.032235"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2009.11928457"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I2A31"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.15305"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9I10A200"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.116.003560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:22:27Z","timestamp":1715566947000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.116.003560"}},"subtitle":["A Propensity Score\u2013Corrected Analysis From the British Cardiovascular Intervention Society"],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.116.003560"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.116.003560","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"type":"print","value":"1941-7640"},{"type":"electronic","value":"1941-7632"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"2016-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e003560"}}