{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:09:23Z","timestamp":1768072163624,"version":"3.49.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The main causes of late (&gt;1 month) stent thrombosis (ST) are stent uncoverage, malapposition, and neoatherosclerosis. First-generation drug-eluting stents were associated with higher rate of late ST compared with bare-metal stents (BMS), especially in patients with ST-segment\u2013elevation myocardial infarction. Second-generation everolimus-eluting stents (EES) have shown similar rate of late ST than BMS. The aims of the study are to compare the ratio of uncovered to total struts per cross-section \u226530% and other optical coherence tomographic findings associated with ST between EES and BMS in patients with ST-segment\u2013elevation myocardial infarction at 5 years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              One hundred and sixty-nine consecutive event-free patients of the randomized EXAMINATION study (A Clinical Evaluation of Everolimus Eluting Coronary Stents in the Treatment of Patients With ST-Segment Elevation Myocardial Infarction) were screened for optical coherence tomographic imaging at 5 years. Patients with target vessel\u2013related events or life-threatening comorbidities were excluded. Finally, 64 patients (32 EES and 32 BMS) underwent optical coherence tomographic imaging. At 5 years, uncovered struts (4.1% versus 1.0%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01), length of uncoverage (3.4 versus 1.4 mm;\n              <jats:italic>P<\/jats:italic>\n              =0.02), and ratio of uncovered to total struts per cross-section \u226530% (35.5% versus 9.7%;\n              <jats:italic>P<\/jats:italic>\n              =0.02) were larger with EES than that with BMS. Malapposed struts (1.2% versus 0.3%;\n              <jats:italic>P<\/jats:italic>\n              =0.02) and malapposition length (1.3 versus 0.4 mm;\n              <jats:italic>P<\/jats:italic>\n              =0.06) were also larger with EES. Neoatherosclerotic plaques (16.1% versus 25.8%;\n              <jats:italic>P<\/jats:italic>\n              =0.35) and macrophage accumulations (19.4% versus 48.4%;\n              <jats:italic>P<\/jats:italic>\n              =0.02) were numerically more frequent with BMS.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Despite substantial dropout of patients, the healing pattern in event-free ST-segment\u2013elevation myocardial infarction patients differs between EES and BMS at 5 years. EES presented with larger amount of uncovered and malapposed struts and similar rate of neoatherosclerosis as compared with BMS. The clinical relevance of these findings warrants longer follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00828087.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.116.003670","type":"journal-article","created":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T02:59:44Z","timestamp":1475636384000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Five-Year Optical Coherence Tomography in Patients With ST-Segment\u2013Elevation Myocardial Infarction Treated With Bare-Metal Versus Everolimus-Eluting Stents"],"prefix":"10.1161","volume":"9","author":[{"given":"Josep","family":"Gomez-Lara","sequence":"first","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Brugaletta","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Jacobi","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Ortega-Paz","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"\u00d1ato","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Roura","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Romaguera","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose-Luis","family":"Ferreiro","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Teruel","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Gracida","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Martin-Yuste","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Freixa","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Masotti","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan-Antoni","family":"Gomez-Hospital","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Sabate","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); and Hospital Cl\u00ednic i Provincial de Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer, Spain (S.B., L.O.-P., V.M.-Y., X.F., M.M., M.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Cequier","sequence":"additional","affiliation":[{"name":"From the Hospital Universitari de Bellvitge, Institut d\u2019 Investigaci\u00f3 Biom\u00e8dica de Bellvitge, Universitat de Barcelona, L\u2019 Hospitalet de Llobregat, Spain (J.G.-L., F.J., M.\u00d1., G.R., R.R., J.-L.F., L.T., M.G., J.-A.G.-H., A.C.); 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