{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:42:26Z","timestamp":1792078946690,"version":"4.4.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The benefits and harms of dual antiplatelet therapy (DAPT) continuation beyond 1 year after drug-eluting stent implantation as compared with 1-year DAPT remain controversial.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We searched for randomized trials that compared longer than 1-year DAPT versus 1-year DAPT after drug-eluting stenting. A meta-analysis was performed by using standard frequentist and random-effects Bayesian approaches. Four trials comprising 17\u2009650 participants were included. Compared with 1-year DAPT, extended DAPT did not affect all-cause mortality (odds ratio [OR], 1.11; 95% confidence interval [CI], 0.79\u20131.5;\n              <jats:italic>P<\/jats:italic>\n              =0.53) or cardiovascular mortality (OR, 1.03; 95% CI, 0.72\u20131.46;\n              <jats:italic>P<\/jats:italic>\n              =0.88). Extended DAPT was associated with a reduction in the risk of myocardial infarction (OR, 0.56; 95% CI, 0.43\u20130.73;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), nonsignificant reductions of stent thrombosis (OR, 0.46; 95% CI, 0.16\u20131.27;\n              <jats:italic>P<\/jats:italic>\n              =0.13), similar risk of stroke (OR, 0.91; 95% CI, 0.65\u20131.26;\n              <jats:italic>P<\/jats:italic>\n              =0.56), and an increased risk of major bleeding (OR, 1.49; 95% CI, 1.06\u20132.11;\n              <jats:italic>P<\/jats:italic>\n              =0.02). By using Bayesian meta-analysis, we found moderate evidence of a reduction of myocardial infarction (OR, 0.62; 95% credible intervals, 0.39\u20131.05) and weak evidence of an increase in major bleeding (OR, 1.66; 95% credible intervals, 0.89\u20133.09) associated with extended DAPT.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In this meta-analysis, extended DAPT beyond 1 year prevented myocardial infarctions and increased major bleedings, but the strength of evidence for these effects was not strong. DAPT continuation beyond 1 year showed no effects on mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.116.004139","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T01:00:28Z","timestamp":1494637228000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Dual Antiplatelet Therapy Continuation Beyond 1 Year After Drug-Eluting Stents"],"prefix":"10.1161","volume":"10","author":[{"given":"Giuseppe","family":"Ferrante","sequence":"first","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Humanitas Clinical and Research Center, Rozzano, Milan, Italy (G.F., G.C., P.P., B.R.); and Humanitas University, Rozzano, Italy (G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Condorelli","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Humanitas Clinical and Research Center, Rozzano, Milan, Italy (G.F., G.C., P.P., B.R.); and Humanitas University, Rozzano, Italy (G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pagnotta","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Humanitas Clinical and Research Center, Rozzano, Milan, Italy (G.F., G.C., P.P., B.R.); and Humanitas University, Rozzano, Italy (G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Reimers","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Medicine, Humanitas Clinical and Research Center, Rozzano, Milan, Italy (G.F., G.C., P.P., B.R.); and Humanitas University, Rozzano, Italy (G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067722"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60314-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.2.joc60179"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.180944"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003303"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60612-7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409312"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60263-X"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h1618"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62052-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv481"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_3_2_14_2","volume-title":"Chapter 8: assessing risk of bias in included studies","author":"Higgins JPT","unstructured":"Higgins JPT, Altman DG, Sterne JACeds. 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