{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:19:35Z","timestamp":1783441175788,"version":"3.54.6"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Data on the association between glycemic control after percutaneous coronary intervention and clinical outcomes are limited and controversial in diabetic patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We studied 980 patients with type 2 diabetes mellitus undergoing percutaneous coronary intervention using drug-eluting stents. Based on 2-year glycosylated hemoglobin A (HbA1c) levels, we divided patients into 2 groups of HbA1c&lt;7.0 (n=489) and HbA1c\u22657.0 (n=491). Propensity score\u2013matched analysis was performed in 322 pairs. The primary outcome was major adverse cardiac and cerebrovascular events (MACCE), defined as a composite of cardiac death, myocardial infarction, repeat revascularization, or stroke. Median follow-up duration was 5.4 years. The 7-year incidence of MACCE was lower in the HbA1c&lt;7.0 group than in the HbA1c\u22657.0 group (26.9% versus 40.3%; adjusted hazard ratio, 0.75; 95% confidence interval, 0.57\u20130.98;\n              <jats:italic>P<\/jats:italic>\n              =0.03). After propensity score matching, the 7-year incidence of MACCE was still lower in the HbA1c&lt;7.0 group than in the HbA1c\u22657.0 group (27.5% versus 37.4%; hazard ratio, 0.71; 95% confidence interval, 0.52\u20130.97;\n              <jats:italic>P<\/jats:italic>\n              =0.03), mainly because of a reduction in repeat revascularization (19.9% versus 29.5%; hazard ratio, 0.66; 95% confidence interval, 0.47\u20130.93;\n              <jats:italic>P<\/jats:italic>\n              =0.02). In subgroup analyses, the benefit of glycemic control for MACCE was more prominent in patients with residual SYNTAX score (Synergy Between PCI With Taxus and Cardiac Surgery) &gt;4 than in those with the residual SYNTAX score \u22644 (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>interaction<\/jats:sub>\n              =0.004).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>HbA1c&lt;7.0 measured 2 years after percutaneous coronary intervention was associated with a reduced rate of MACCE. Our data suggest that high HbA1c levels 2 years after percutaneous coronary intervention may identify a population at increased risk of adverse events, especially repeat revascularization.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.116.004157","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T01:12:20Z","timestamp":1491268340000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Glycemic Control Status After Percutaneous Coronary Intervention and Long-Term Clinical Outcomes in Patients With Type 2 Diabetes Mellitus"],"prefix":"10.1161","volume":"10","author":[{"given":"Jin Kyung","family":"Hwang","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hwa","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Bin","family":"Song","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonghyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keumhee","family":"Carriere","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Ja","family":"Jang","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taek Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hoon","family":"Yang","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon-Cheol","family":"Gwon","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Yong","family":"Hahn","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (J.K.H., Seung Hwa Lee, Y.B.S., M.J.J., T.K.P., S.-H.C., J.H.Y., J.-H.C., Sang Hoon Lee, H.-C.G., J.-Y.H.); Biostatistics and Clinical Epidemiology Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea (J.A., K.C.); and Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-S011"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802987"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806470"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802743"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0474"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.113.001107"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-0264"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht142"},{"key":"e_1_3_4_11_2","first-page":"219","article-title":"The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease.","volume":"1","author":"Sianos G","year":"2005","unstructured":"Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, van den Brand M, Van Dyck N, Russell ME, Mohr FW, Serruys PW. 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