{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:36:43Z","timestamp":1790717803030,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>\n            P2Y\n            <jats:sub>12<\/jats:sub>\n            receptor antagonists, concurrently administered with aspirin in what has come to be commonly called dual antiplatelet therapy, are a mainstay of treatment for patients with acute coronary syndromes. Morphine, on the contrary, is a commonly used drug in the acute phase of acute coronary syndromes to relieve pain\u2014with the added potential benefit of attenuating acutely raised sympathetic tone. In current guidelines, though, morphine is recommended with decreasing strength of recommendation. One reason is that it raises concern regarding the potentially significant interaction with antiplatelet agents, leading to impaired inhibition of platelet activation. In any case, it is still considered a mandatory part of the inventory of available medications in prehospital acute myocardial infarction management. The goal of the present review is to present published evidence on morphine and its potential interactions with P2Y\n            <jats:sub>12<\/jats:sub>\n            receptor antagonists, as well as on the central issue of whether such interactions may underlie clinically significant effects on patient outcomes.\n          <\/jats:p>","DOI":"10.1161\/circinterventions.116.004229","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T03:35:37Z","timestamp":1472787337000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["P2Y\n            <sub>12<\/sub>\n            Receptor Antagonists and Morphine"],"prefix":"10.1161","volume":"9","author":[{"given":"Georgios","family":"Giannopoulos","sequence":"first","affiliation":[{"name":"From the Second Department of Cardiology, National and Kapodistrean University of Athens, Attikon University Hospital, Greece (G.G., S.D., F.K., J.L., D.A.); and Department of Cardiology, University of Patras, University Hospital of Rio, Greece (I.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon","family":"Deftereos","sequence":"additional","affiliation":[{"name":"From the Second Department of Cardiology, National and Kapodistrean University of Athens, Attikon University Hospital, Greece (G.G., S.D., F.K., J.L., D.A.); and Department of Cardiology, University of Patras, University Hospital of Rio, Greece (I.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotios","family":"Kolokathis","sequence":"additional","affiliation":[{"name":"From the Second Department of Cardiology, National and Kapodistrean University of Athens, Attikon University Hospital, Greece (G.G., S.D., F.K., J.L., D.A.); and Department of Cardiology, University of Patras, University Hospital of Rio, Greece (I.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Xanthopoulou","sequence":"additional","affiliation":[{"name":"From the Second Department of Cardiology, National and Kapodistrean University of Athens, Attikon University Hospital, Greece (G.G., S.D., F.K., J.L., D.A.); and Department of Cardiology, University of Patras, University Hospital of Rio, Greece (I.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lekakis","sequence":"additional","affiliation":[{"name":"From the Second Department of Cardiology, National and Kapodistrean University of Athens, Attikon University Hospital, Greece (G.G., S.D., F.K., J.L., D.A.); and Department of Cardiology, University of Patras, University Hospital of Rio, Greece (I.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Alexopoulos","sequence":"additional","affiliation":[{"name":"From the Second Department of Cardiology, National and Kapodistrean University of Athens, Attikon University Hospital, Greece (G.G., S.D., F.K., J.L., D.A.); and Department of Cardiology, University of Patras, University Hospital of Rio, Greece (I.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000404"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs215"},{"key":"e_1_3_2_4_2","first-page":"2999","article-title":"2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation.","volume":"32","author":"Roffi M","year":"2015","unstructured":"Roffi M, Patrono C, Collet J-P, Mueller C, Valgimigli M, Andreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeldsen K, Lancellotti P, Landmesser U, Mehilli J, Mukherjee D, Storey RF, Windecker S. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. 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