{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:54:00Z","timestamp":1788587640044,"version":"build-2803163510"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>There is general agreement that the optimal duration of dual antiplatelet therapy (DAPT) in patients treated with drug-eluting stents should be individualized. We hypothesized that the extent of coronary artery disease may affect the clinical outcomes of DAPT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We pooled patient-level data from 5 large, randomized trials comparing short-term DAPT with prolonged therapy. From the data, we identified 5476 patients who received newer-generation drug-eluting stents. Net adverse clinical event (NACE) was defined as a composite of all-cause mortality, myocardial infarction, stroke, or major bleeding. At 1 year, NACE had occurred in 171 patients (3.1%). Independent predictors of NACE were older age (&gt;65 years), sex, presence of diabetes mellitus, left ventricular dysfunction (ejection fraction &lt;40%), and angiographic multivessel disease. Multivessel disease and DAPT duration were significantly associated with NACE (\n              <jats:italic>P<\/jats:italic>\n              for interaction=0.002); the association was driven by the greater occurrence of myocardial infarction in patients with multivessel disease. In patients with multivessel disease, 6-month DAPT (versus 12-month DAPT) was associated with a higher incidence of myocardial infarction (adjusted hazard ratio=2.748; 95% confidence interval=1.375\u20135.491;\n              <jats:italic>P<\/jats:italic>\n              =0.004), compared with patients with single-vessel disease (\n              <jats:italic>P<\/jats:italic>\n              for interaction=0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In patients treated with newer-generation drug-eluting stents, a significant interaction between DAPT strategy and multivessel disease was found regarding the occurrence of NACE at 1 year. Among adverse events, myocardial infarction was more frequent in 6-month DAPT than in 12-month DAPT in patients with multivessel disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.116.004256","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T02:44:28Z","timestamp":1478054668000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Association Between Duration of Dual Antiplatelet Therapy and Angiographic Multivessel Disease on Outcomes in Patients Treated With Newer-Generation Drug-Eluting Stents"],"prefix":"10.1161","volume":"9","author":[{"given":"Seung-Yul","family":"Lee","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine, Gunpo, Korea (S.-Y.L.); Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.); Cardiovascular Research Institute (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.) and Severance Biomedical Science Institute (M.-K.H., Y.J.), Yonsei University College of Medicine, Seoul, Korea; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong-Ki","family":"Hong","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine, Gunpo, Korea (S.-Y.L.); Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.); Cardiovascular Research Institute (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.) and Severance Biomedical Science Institute (M.-K.H., Y.J.), Yonsei University College of Medicine, Seoul, Korea; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Ho","family":"Shin","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine, Gunpo, Korea (S.-Y.L.); Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.); Cardiovascular Research Institute (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.) and Severance Biomedical Science Institute (M.-K.H., Y.J.), Yonsei University College of Medicine, Seoul, Korea; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine, Gunpo, Korea (S.-Y.L.); Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.); Cardiovascular Research Institute (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.) and Severance Biomedical Science Institute (M.-K.H., Y.J.), Yonsei University College of Medicine, Seoul, Korea; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong-Keuk","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine, Gunpo, Korea (S.-Y.L.); Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.); Cardiovascular Research Institute (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.) and Severance Biomedical Science Institute (M.-K.H., Y.J.), Yonsei University College of Medicine, Seoul, Korea; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Guk","family":"Ko","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine, Gunpo, Korea (S.-Y.L.); Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.); Cardiovascular Research Institute (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.) and Severance Biomedical Science Institute (M.-K.H., Y.J.), Yonsei University College of Medicine, Seoul, Korea; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghoon","family":"Choi","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine, Gunpo, Korea (S.-Y.L.); Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.); Cardiovascular Research Institute (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.) and Severance Biomedical Science Institute (M.-K.H., Y.J.), Yonsei University College of Medicine, Seoul, Korea; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangsoo","family":"Jang","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine, Gunpo, Korea (S.-Y.L.); Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.); Cardiovascular Research Institute (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.) and Severance Biomedical Science Institute (M.-K.H., Y.J.), Yonsei University College of Medicine, Seoul, Korea; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine, Gunpo, Korea (S.-Y.L.); Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.); Cardiovascular Research Institute (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.) and Severance Biomedical Science Institute (M.-K.H., Y.J.), Yonsei University College of Medicine, Seoul, Korea; 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Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.); Cardiovascular Research Institute (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.) and Severance Biomedical Science Institute (M.-K.H., Y.J.), Yonsei University College of Medicine, Seoul, Korea; Department..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine, Sanbon Hospital, Wonkwang University College of Medicine, Gunpo, Korea (S.-Y.L.); Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.); Cardiovascular Research Institute (M.-K.H., D.-H.S., J.-S.K., B.-K.K., Y.-G.K., D.C., Y.J.) and Severance Biomedical Science Institute (M.-K.H., Y.J.), Yonsei University College of Medicine, Seoul, Korea; 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