{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:00Z","timestamp":1787018040831,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>There is little evidence regarding the efficacy and safety of bioresorbable scaffolds (BRS) for the percutaneous treatment of chronic total occlusions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      We performed a multicenter registry of consecutive chronic total occlusion patients treated with BRS (Absorb; Abbott Vascular) and second-generation drug-eluting stents (DES) at 5 institutions. Long-term target-vessel failure (a composite of cardiac death, target-vessel myocardial infarction, and ischemia-driven target-lesion revascularization) was the primary end point. Inverse probability of treatment weight\u2013adjusted Cox regression was used to account for pretreatment differences between the 2 groups. A total of 537 patients (n=153 BRS; n=384 DES) were included. BRS patients were younger and had lower prevalence of comorbidities. Overall mean Japan-Chronic Total Occlusion (J-CTO) score was 1.43\u00b11.16, with no differences between groups. Procedural success was achieved in 99.3% and 96.6% of BRS- and DES-treated patients, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      =0.07). At a median follow-up of 703 days, there were no differences in target-vessel failure between BRS and DES (4.6% versus 7.7%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.21). By adjusted Cox regression analysis, there were still no significant differences between BRS and DES (hazard ratio, 1.54; 95% confidence interval, 0.69\u20133.72;\n                      <jats:italic>P<\/jats:italic>\n                      =0.34). However, secondary analyses suggested a signal toward higher ischemia-driven target-lesion revascularization with BRS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Implantation of BRS versus second-generation DES in chronic total occlusion was associated with similar risk of target-vessel failure at long-term follow-up. However, a signal toward increased ischemia-driven target-lesion revascularization with BRS was observed. Large randomized studies should confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.116.004284","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T23:33:34Z","timestamp":1475883214000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Procedural and Long-Term Outcomes of Bioresorbable Scaffolds Versus Drug-Eluting Stents in Chronic Total Occlusions"],"prefix":"10.1161","volume":"9","author":[{"given":"Lorenzo","family":"Azzalini","sequence":"first","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Giustino","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Ojeda","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Serra","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"La Manna","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung Q.","family":"Ly","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bellini","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Benincasa","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Chavarr\u00eda","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia L.","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Longo","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eligio","family":"Miccich\u00e8","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"D\u2019Agosta","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Picard","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Pan","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Carlino","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaide","family":"Chieffo","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Colombo","sequence":"additional","affiliation":[{"name":"From the Interventional Cardiology Unit, Cardio-Thoraco-Vascular Department, San Raffaele Scientific Institute, Milan, Italy (L.A., B.B., S.B., A.L., M.C., A. Chieffo, A. Colombo); Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (G.G.); Department of Cardiology, Reina Sof\u00eda Hospital, University of C\u00f3rdoba (IMIBIC), Spain (S.O., J.C., M.P.); Interventional Cardiology Unit,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61455-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509038"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.054"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv435"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.02.048"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.10.032"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26397"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.12.025"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I1A21"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY15M01_05"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25465"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6607"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.002816"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq439"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.12.238"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht542"},{"key":"e_1_3_2_19_2","first-page":"85","article-title":"Bioresorbable vascular scaffold thrombosis in an all-comer patient population: single-center experience.","volume":"27","author":"Azzalini L","year":"2015","unstructured":"Azzalini L, L\u2019Allier PL. 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J Invasive Cardiol. 2015;27:85\u201392.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00119-0"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00979-4"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.12.019"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.11.055"}],"updated-by":[{"DOI":"10.1161\/hcv.0000000000000021","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000}}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.116.004284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:51:01Z","timestamp":1715554261000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.116.004284"}},"subtitle":["The BONITO Registry (Bioresorbable Scaffolds Versus Drug-Eluting Stents in Chronic Total Occlusions)"],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.116.004284"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.116.004284","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"2016-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e004284"}}