{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:52:46Z","timestamp":1776387166339,"version":"3.51.2"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Current guidelines suggest that coronary artery bypass grafting (CABG) should be the preferred revascularization method for unprotected left main coronary artery stenosis. In light of evidence from recent randomized trials, we assessed whether percutaneous coronary intervention (PCI) using drug-eluting stents is as safe and effective as CABG for the treatment of unprotected left main coronary artery disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Digital databases and manual searches were performed for randomized trials comparing PCI and CABG for unprotected left main coronary artery stenosis. Among 3887 potentially relevant studies, 5 met inclusion criteria. The primary safety end point was defined as the composite of all-cause death, myocardial infarction, or stroke. Secondary end points included a clinical effectiveness composite, which was defined as all-cause death, myocardial infarction, stroke, or repeat revascularization. Summary estimates were obtained using random-effects modeling. In total, 4594 patients were included in the analysis. There was no significant difference in the primary safety end point between the revascularization strategies (odds ratio [OR], 0.97; 95% confidence interval [CI], 0.79\u20131.17;\n              <jats:italic>P<\/jats:italic>\n              =0.73). However, when compared with CABG, PCI was less effective (OR, 1.36; 95% CI, 1.18\u20131.58;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) because of significantly higher rates of repeat revascularization (OR, 1.85; 95% CI, 1.53\u20132.23;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The incidence of all-cause death (OR, 1.03; 95% CI, 0.78\u20131.35;\n              <jats:italic>P<\/jats:italic>\n              =0.61), myocardial infarction (OR, 1.46; 95% CI, 0.88\u20132.45;\n              <jats:italic>P<\/jats:italic>\n              =0.08), and stroke (OR, 0.88; 95% CI, 0.39\u20131.97;\n              <jats:italic>P<\/jats:italic>\n              =0.53) did not differ between PCI and CABG.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>PCI using drug-eluting stents and CABG are equally safe methods of revascularization for patients at low surgical risk with significant unprotected left main coronary artery stenosis. However, CABG is associated with significantly lower rates of repeat revascularization.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.116.004729","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T04:34:47Z","timestamp":1480480487000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Percutaneous Coronary Intervention Using Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Stenosis"],"prefix":"10.1161","volume":"9","author":[{"given":"Nitesh","family":"Nerlekar","sequence":"first","affiliation":[{"name":"From the Monash Cardiovascular Research Centre, Monash University, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); MonashHeart, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); Monash Health, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); and Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (M.R.B., A.J.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis J.","family":"Ha","sequence":"additional","affiliation":[{"name":"From the Monash Cardiovascular Research Centre, Monash University, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); MonashHeart, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); Monash Health, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); and Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (M.R.B., A.J.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunal P.","family":"Verma","sequence":"additional","affiliation":[{"name":"From the Monash Cardiovascular Research Centre, Monash University, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); MonashHeart, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); Monash Health, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); and Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (M.R.B., A.J.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin R.","family":"Bennett","sequence":"additional","affiliation":[{"name":"From the Monash Cardiovascular Research Centre, Monash University, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); MonashHeart, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); Monash Health, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); and Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (M.R.B., A.J.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Cameron","sequence":"additional","affiliation":[{"name":"From the Monash Cardiovascular Research Centre, Monash University, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); MonashHeart, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); Monash Health, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); and Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (M.R.B., A.J.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian T.","family":"Meredith","sequence":"additional","affiliation":[{"name":"From the Monash Cardiovascular Research Centre, Monash University, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); MonashHeart, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); Monash Health, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); and Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (M.R.B., A.J.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J.","family":"Brown","sequence":"additional","affiliation":[{"name":"From the Monash Cardiovascular Research Centre, Monash University, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); MonashHeart, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); Monash Health, Clayton, Victoria, Australia (N.N., F.J.H., K.P.V., J.D.C., I.T.M., A.J.B.); and Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (M.R.B., A.J.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr426"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.9.2335"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.067"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0b013e318277d6a0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu366"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.06.051"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.05.136"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32052\u20139"},{"key":"e_1_3_3_10_2","article-title":"Everolimus-eluting stents or bypass surgery for left main coronary artery disease [published online ahead of print October 31, 2016].","author":"Stone GW","unstructured":"Stone GW, Sabik JF, Serruys PW, Simonton CA, G\u00e9n\u00e9reux P, Puskas J, Kandzari DE, Morice M-C, Lembo N, Brown WMI, Taggart DP, Banning A, Merkely B, Horkay F, Boonstra PW, van Boven AJ, Ungi I, Bog\u00e1ts G, Mansour S, Noiseux N, Sabat\u00e9 M, Pomar J, Hickey M, Gershlick A, Buszman P, Bochenek A, Schampaert E, Pag\u00e9 P, Dressler O, Kosmidou I, Mehran R, Pocock SJ, Kappetein AP; 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Optical coherence tomography compared with intravascular ultrasound and with angiography to guide coronary stent implantation (ILUMIEN III: OPTIMIZE PCI): a randomised controlled trial [published online ahead of print October 30 2016]. doi: 10.1016\/S0140-6736(16)31922\u20135.","DOI":"10.1016\/S0140-6736(16)31922\u20135"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.06.005"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7136.989"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.116.004729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:35:09Z","timestamp":1715567709000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.116.004729"}},"subtitle":["A Meta-Analysis of Randomized Trials"],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.116.004729"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.116.004729","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"2016-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e004729"}}