{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:59:53Z","timestamp":1777417193396,"version":"3.51.4"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The objective of this study is to test the effect of permanent right internal mammary artery device closure on coronary collateral function and myocardial ischemia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              This was a prospective, open-label clinical trial in 50 patients with coronary artery disease. The primary study end point was coronary collateral flow index as obtained during a 1-minute proximal right coronary artery (RCA) and left coronary artery balloon occlusion at baseline before and at follow-up examination 6 weeks after distal right internal mammary artery device closure. Collateral flow index is the ratio between simultaneously recorded mean coronary occlusive pressure divided by mean aortic pressure, both subtracted by central venous pressure. Secondary study end points were fractional flow reserve during vessel patency, the quantitative intracoronary ECG ST-segment elevation, and angina pectoris during the same 1-minute coronary occlusion. Collateral flow index in the untreated RCA and left coronary artery changed from 0.071\u00b10.082 at baseline to 0.132\u00b10.117 (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) at follow-up examination and from 0.106\u00b10.092 to 0.081\u00b10.079 (\n              <jats:italic>P<\/jats:italic>\n              =0.29), respectively. RCA fractional flow reserve increased significantly (\n              <jats:italic>P<\/jats:italic>\n              =0.0029) from baseline to follow-up examination, despite deferral of coronary intervention in all patients. There was a decrease in intracoronary ECG ST-elevation during RCA occlusion from baseline to follow-up examination (\n              <jats:italic>P<\/jats:italic>\n              =0.0015); it did not change in the left coronary artery. Angina pectoris during RCA occlusion tended to occur in fewer patients at follow-up versus baseline examination (\n              <jats:italic>P<\/jats:italic>\n              =0.06).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Permanent right internal mammary artery device closure seems to augment extracardiac ipsilateral coronary supply to the effect of reducing ischemia in the dependent myocardial region.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT02475408.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.116.004990","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:50:24Z","timestamp":1496278224000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Permanent Right Internal Mammary Artery Closure on Coronary Collateral Function and Myocardial Ischemia"],"prefix":"10.1161","volume":"10","author":[{"given":"Michael","family":"Stoller","sequence":"first","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Seiler","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology, Bern University Hospital, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22431"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq500"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/15.11.668"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr308"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304369"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.56.6.919"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418516700600306"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ca.21088"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810080312"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(93)91017-9"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(94)90102-3"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0304(199702)40:2<170::AID-CCD11>3.0.CO;2-V"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.65.753"},{"key":"e_1_3_4_15_2","first-page":"E209","article-title":"A rare form of communication between the left internal thoracic artery and the left anterior descending artery.","volume":"18","author":"Aras D","year":"2006","unstructured":"Aras D, Topaloglu S, Cagli K, Ergun K, Ozeke O, Korkmaz S. A rare form of communication between the left internal thoracic artery and the left anterior descending artery. J Invasive Cardiol. 2006;18:E209\u2013E210.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011126"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196008000-00018"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2011.07.001"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008898"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00384-2"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104719"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi585"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.2.330"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.2706"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003712.pub3"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.11.017"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.05.003"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.184507"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht195"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.061"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303305"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00674-3"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304187"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402556"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.07.016"},{"key":"e_1_3_4_36_2","first-page":"5","article-title":"Anastomoses between extracardiac vessels and coronary arteries.","volume":"485","author":"Moberg A","year":"1968","unstructured":"Moberg A. Anastomoses between extracardiac vessels and coronary arteries. Acta Med Scand Suppl. 1968;485:5\u201326.","journal-title":"Acta Med Scand Suppl"},{"key":"e_1_3_4_37_2","first-page":"1178","article-title":"[Ligation of the two internal mammary arteries in vascular disorders of the myocardium; preventive note concerning the first experimental and clinical findings].","volume":"46","author":"Battezzati M","year":"1955","unstructured":"Battezzati M, Tagliaferro A, de Marchi G. [Ligation of the two internal mammary arteries in vascular disorders of the myocardium; preventive note concerning the first experimental and clinical findings]. Minerva Med. 1955;46:1178\u20131188.","journal-title":"Minerva Med"},{"key":"e_1_3_4_38_2","first-page":"342","article-title":"Cardiology\u2019s 10 greatest discoveries.","volume":"29","author":"Haller JD","year":"2002","unstructured":"Haller JD, Olearchyk AS. Cardiology\u2019s 10 greatest discoveries. Tex Heart Inst J. 2002;29:342\u2013344.","journal-title":"Tex Heart Inst J"},{"key":"e_1_3_4_39_2","first-page":"305","article-title":"Criteri anatomo-fisiologici per intervento chirurgico lieve in malati di infarto e cuore di angina.","volume":"63","author":"Fieschi D","year":"1942","unstructured":"Fieschi D. Criteri anatomo-fisiologici per intervento chirurgico lieve in malati di infarto e cuore di angina. Arch Ital Chir. 1942;63:305\u2013310.","journal-title":"Arch Ital Chir"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(59)90245-0"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(58)90074-2"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195905282602204"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(60)90105-3"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1961.63040260007008"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2012.09.002"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.068"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.866269"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304880"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e3280565dee"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.116.004990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:56:42Z","timestamp":1715569002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.116.004990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.116.004990"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.116.004990","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"2016-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e004990"}}