{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:09:22Z","timestamp":1790186962637,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Surgical aortic valve replacement in patients with small annular dimensions is challenging because they are at increased risk for prosthesis\u2013patient mismatch and impaired outcomes. Transcatheter aortic valve replacement might be a good alternative; however, comparative data on different transcatheter heart valves are missing.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              This multicenter, propensity score\u2013matched study compared hemodynamics and early clinical outcomes in 246 patients with an aortic annulus area &lt;400 mm\n              <jats:sup>2<\/jats:sup>\n              undergoing transcatheter aortic valve replacement with either a self-expanding transcatheter heart valve (Symetis ACURATE neo, n=129) or a balloon-expandable transcatheter heart valve (Edwards SAPIEN 3, n=117). The 1:1 propensity score matching resulted in 92 matched pairs. For ACURATE neo versus SAPIEN 3-treated patients, 30-day mortality (0.0% versus 1.0%), 1-year mortality (8.3% versus 13.3%), incidence of stroke (3.3% versus 2.2%), life-threatening bleeding (1.1% versus 1.1%), and major vascular complications (2.2% versus 6.5%), as well as pacemaker implantation rate (12.0% versus 15.2%), were similar. Paravalvular regurgitation \u2265moderate was rare in both groups (4.5% versus 3.6%). The ACURATE neo presented lower mean transvalvular gradients (9.3 versus 14.5 mm\u2009Hg;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), larger indexed effective orifice areas (0.96 versus 0.80 cm\n              <jats:sup>2<\/jats:sup>\n              \/m\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.003), and lower rates of severe prosthesis\u2013patient mismatch (3% versus 22%;\n              <jats:italic>P<\/jats:italic>\n              =0.004). Hemodynamics were sustained at 1-year follow-up.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Albeit a similar safety profile with low clinical event rates, transcatheter aortic valve replacement with the ACURATE neo valve resulted in lower transvalvular gradients and consequently less prosthesis\u2013patient mismatch compared with the SAPIEN 3 in patients with small annulus. These results emphasize the need of careful prosthesis selection in each individual patient.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.117.005013","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:50:17Z","timestamp":1506473417000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":112,"title":["Short-Term Outcome and Hemodynamic Performance of Next-Generation Self-Expanding Versus Balloon-Expandable Transcatheter Aortic Valves in Patients With Small Aortic Annulus"],"prefix":"10.1161","volume":"10","author":[{"given":"Victor","family":"Mauri","sequence":"first","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won K.","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Abumayyaleh","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Walther","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"Moellmann","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Schaefer","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenard","family":"Conradi","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hengstenberg","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hilker","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Wahlers","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Rudolph","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Madershahian","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja K.","family":"Rudolph","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (V.M., M.A., S.B., V.R., T.K.R.) and Cardiothoracic Surgery (T.W., N.M.), Heart Center, University of Cologne, Germany; Departments of Cardiology (W.K.K.) and Cardiac Surgery (T.W.), Kerckhoff Clinic, Bad Nauheim, Germany; Department of Internal Medicine, St. Johannes-Hospital, Dortmund, Germany (H.M.); Departments of General and Interventional Cardiology (U.S.) and Cardiovascular Surgery (L.C.), University Heart Center, University Hospital Hamburg-Eppendorf (UKE),..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.778886"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.10.026"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.901272"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2016.06.058"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.01.059"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1195"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.10.070"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9SSA22"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.09.019"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.002"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV11I9A211"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.065"},{"key":"e_1_3_2_15_2","unstructured":"Moellmann H. 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