{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:39:40Z","timestamp":1765827580727,"version":"3.41.2"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Data regarding the long-term efficacy and safety of everolimus-eluting bioresorbable vascular scaffolds (BVS) compared with everolimus-eluting stents are limited. This meta-analysis aimed to compare the long-term outcomes with both devices.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>Randomized trials reporting clinical outcomes beyond 1 year and comparing BVS with everolimus-eluting stents were included. Summary estimates risk ratios (RRs) were constructed. The primary efficacy outcome was target lesion failure, defined as cardiac death, target vessel myocardial infarction, and ischemia-driven target lesion revascularization, and the primary safety outcome was definite or probable stent\/scaffold thrombosis. Six trials with 5392 patients were included (mean follow-up, 25 months). BVS had a higher rate of target lesion failure (RR, 1.33; 95% confidence interval [CI], 1.11\u20131.58) driven by the higher rates of target vessel myocardial infarction (RR, 1.65; 95% CI, 1.26\u20132.17) and target lesion revascularization (RR, 1.39; 95% CI, 1.08\u20131.78). The risk of definite or probable stent\/scaffold thrombosis (RR, 3.22; 95% CI, 1.89\u20135.49) and very late stent\/scaffold thrombosis (&gt;1 year; RR, 4.78; 95% CI, 1.66\u201313.8) was higher with BVS. The risk of cardiac and all-cause mortality was similar in both groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Compared with everolimus-eluting stents, BVS is associated with increased risk of target lesion failure driven by the increased rates of target vessel myocardial infarction and ischemia-driven target lesion revascularization in these studies (mean follow-up, 25 months). The risk of definite or probable stent\/scaffold thrombosis and very late stent\/scaffold thrombosis seems to be higher with BVS. Further information from randomized trials is critical to evaluate clinical outcomes with BVS on complete resolution of the scaffold.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.117.005286","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T01:20:28Z","timestamp":1493860828000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Long-Term Efficacy and Safety of Everolimus-Eluting Bioresorbable Vascular Scaffolds Versus Everolimus-Eluting Metallic Stents"],"prefix":"10.1161","volume":"10","author":[{"given":"Ahmed N.","family":"Mahmoud","sequence":"first","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville (A.N.M., A.Y.E., E.S., I.Y.E.); Department of Medicine, Cleveland Clinic Foundation, OH (A.F.B.); Division of Cardiovascular Medicine, Department of Medicine, University of Iowa Carver College of Medicine (A.M.); and Department of Cardiovascular Medicine, Sidney Kimmel Medical College at Thomas Jefferson University\/Christiana Care Health System, Newark, DE (A.A.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr F.","family":"Barakat","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville (A.N.M., A.Y.E., E.S., I.Y.E.); Department of Medicine, Cleveland Clinic Foundation, OH (A.F.B.); Division of Cardiovascular Medicine, Department of Medicine, University of Iowa Carver College of Medicine (A.M.); and Department of Cardiovascular Medicine, Sidney Kimmel Medical College at Thomas Jefferson University\/Christiana Care Health System, Newark, DE (A.A.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akram Y.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville (A.N.M., A.Y.E., E.S., I.Y.E.); Department of Medicine, Cleveland Clinic Foundation, OH (A.F.B.); Division of Cardiovascular Medicine, Department of Medicine, University of Iowa Carver College of Medicine (A.M.); and Department of Cardiovascular Medicine, Sidney Kimmel Medical College at Thomas Jefferson University\/Christiana Care Health System, Newark, DE (A.A.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Schneibel","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville (A.N.M., A.Y.E., E.S., I.Y.E.); Department of Medicine, Cleveland Clinic Foundation, OH (A.F.B.); Division of Cardiovascular Medicine, Department of Medicine, University of Iowa Carver College of Medicine (A.M.); and Department of Cardiovascular Medicine, Sidney Kimmel Medical College at Thomas Jefferson University\/Christiana Care Health System, Newark, DE (A.A.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amgad","family":"Mentias","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville (A.N.M., A.Y.E., E.S., I.Y.E.); Department of Medicine, Cleveland Clinic Foundation, OH (A.F.B.); Division of Cardiovascular Medicine, Department of Medicine, University of Iowa Carver College of Medicine (A.M.); and Department of Cardiovascular Medicine, Sidney Kimmel Medical College at Thomas Jefferson University\/Christiana Care Health System, Newark, DE (A.A.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Abuzaid","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville (A.N.M., A.Y.E., E.S., I.Y.E.); Department of Medicine, Cleveland Clinic Foundation, OH (A.F.B.); Division of Cardiovascular Medicine, Department of Medicine, University of Iowa Carver College of Medicine (A.M.); and Department of Cardiovascular Medicine, Sidney Kimmel Medical College at Thomas Jefferson University\/Christiana Care Health System, Newark, DE (A.A.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islam Y.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"From the Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville (A.N.M., A.Y.E., E.S., I.Y.E.); Department of Medicine, Cleveland Clinic Foundation, OH (A.F.B.); Division of Cardiovascular Medicine, Department of Medicine, University of Iowa Carver College of Medicine (A.M.); and Department of Cardiovascular Medicine, Sidney Kimmel Medical College at Thomas Jefferson University\/Christiana Care Health System, Newark, DE (A.A.)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.017"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001790"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-013-0615-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.971549"},{"key":"e_1_3_2_6_2","unstructured":"http:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm509805.htm. Accessed March 10 2017."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509038"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00979-4"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.09.024"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.03.070"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.10.027"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016\u2013310886"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614954"},{"key":"e_1_3_2_14_2","unstructured":"Ellis SG. Everolimus-eluting bioresorbable vascular scaffolds in patients with coronary artery disease: ABSORB III Trial 2-Year results. American College of Cardiology Annual Scientific Session Washington DC March 18 2017."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-1-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067731"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(85)80003-7"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1187"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32050-5"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","unstructured":"Puricel S. Comparison of everolimus and biolimus-eluting coronary stents with everolimus-eluting bioresorbable vascular scaffolds: 2-year outcomes of the EVERBIO II trial. Presented at TCT 2015 San Francisco CA October 2015.","DOI":"10.1016\/j.jacc.2014.12.017"},{"key":"e_1_3_2_26_2","unstructured":"Gao R. Two-year clinical results in patients with coronary artery disease randomized to the Absorb bioresorbable vascular scaffold versus metallic drug-eluting stents. Presented at TCT 2016 Washington DC October 2016."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY16M09_01"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY16M08_01"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY14M07_11"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.10.005"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.7326\/M16-0006"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.02.011"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1703202"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.003700"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.042"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-16-00247"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-16-00471"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV12I14A277"},{"key":"e_1_3_2_39_2","unstructured":"Absorb GT1 Bioresorbable Vascular Scaffold (BVS) by Abbott Vascular: letter to health care providers - FDA investigating increased rate of major adverse cardiac events. https:\/\/www.fda.gov\/Safety\/MedWatch\/SafetyInformation\/SafetyAlertsforHumanMedicalProducts\/ucm547256.htm. Accessed March 19 2017."}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.117.005286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:25:13Z","timestamp":1715567113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.117.005286"}},"subtitle":["A Meta-Analysis of Randomized Trials"],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.117.005286"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.117.005286","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"type":"print","value":"1941-7640"},{"type":"electronic","value":"1941-7632"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"2017-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e005286"}}