{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:20:03Z","timestamp":1790644803522,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Women may derive differential benefit from prolonged DAPT (dual antiplatelet therapy) after coronary stenting than men. We assessed whether the risks\/benefits of prolonged DAPT differ between women and men.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              The DAPT study was a randomized double-blind, placebo-controlled trial comparing continued thienopyridine versus placebo beyond 12 months after coronary stenting. We compared rates of myocardial infarction, stent thrombosis, major adverse cardiovascular and cerebrovascular events, and bleeding by sex and randomized treatment. Of 11\u2009648 patients, women (N=2925) were older, with higher prevalence of diabetes mellitus and lower rates of acute coronary syndrome than men. At 12 to 30 months, women had similar adjusted ischemic and bleeding events as men. The effects of continued thienopyridine therapy did not differ significantly by sex for stent thrombosis (women: hazard ratio [HR], 0.54; 95% confidence interval [CI], 0.22\u20131.36; men: HR, 0.26; 95% CI, 0.15\u20130.44; interaction\n              <jats:italic>P<\/jats:italic>\n              =0.17), myocardial infarction (women: HR, 0.75; 95% CI, 0.50\u20131.14; men: HR, 0.46; 95% CI, 0.36\u20130.60; interaction\n              <jats:italic>P<\/jats:italic>\n              =0.052), major adverse cardiovascular and cerebrovascular events (women: HR, 0.87; 95% CI, 0.62\u20131.22; men: HR, 0.70; 95% CI, 0.58\u20130.85; interaction\n              <jats:italic>P<\/jats:italic>\n              =0.26), and bleeding (women: HR, 1.45; 95% CI, 0.88\u20132.40; men: HR, 1.78; 95% CI, 1.28\u20132.49; interaction\n              <jats:italic>P<\/jats:italic>\n              =0.50).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Women had similar late risks of ischemia and bleeding as men after coronary stent procedures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00977938.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.117.005308","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T19:53:54Z","timestamp":1536954834000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Benefit and Risk of Prolonged DAPT After Coronary Stenting in Women"],"prefix":"10.1161","volume":"11","author":[{"given":"Natalia C.","family":"Berry","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (N.C.B., L.M.)."},{"name":"Harvard Medical School, Boston, MA (N.C.B., L.M., D.E.C., R.W.Y.)."},{"name":"Baim Institute for Clinical Research, Boston, MA (N.C.B., L.M., D.E.C., R.W.Y., W.-H.H., J.M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean J.","family":"Kereiakes","sequence":"additional","affiliation":[{"name":"The Christ Hospital Heart and Vascular Center and The Lindner Center for Research and Education, Cincinnati, OH (D.J.K)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA (N.C.B., L.M., D.E.C., R.W.Y.)."},{"name":"Baim Institute for Clinical Research, Boston, MA (N.C.B., L.M., D.E.C., R.W.Y., W.-H.H., J.M.M.)."},{"name":"The Smith Center for Outcomes Research in Cardiology (R.W.Y.), Beth Israel Deaconess Medical Center, Boston, MA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Diderot, Sorbonne Paris Cit\u00e9, INSERM Unit\u00e9-1148, D\u00e9partement Hospitalo-Universitaire Fibrosis Inflammation Remodeling, and H\u00f4pital Bichat, Assistance Publique\u2013H\u00f4pitaux de Paris, France (P.G.S.)."},{"name":"National Heart and Lung Institute, Institute of Cardiovascular Medicine and Science, Royal Brompton Hospital, Imperial College, London, United Kingdom (P.G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald E.","family":"Cutlip","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA (N.C.B., L.M., D.E.C., R.W.Y.)."},{"name":"Baim Institute for Clinical Research, Boston, MA (N.C.B., L.M., D.E.C., R.W.Y., W.-H.H., J.M.M.)."},{"name":"Division of Cardiology, Department of Medicine (D.E.C.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice K.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine, Boston, MA (A.K.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Dawn","family":"Abbott","sequence":"additional","affiliation":[{"name":"Rhode Island Hospital, Brown University School of Medicine (J.D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hua","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Baim Institute for Clinical Research, Boston, MA (N.C.B., L.M., D.E.C., R.W.Y., W.-H.H., J.M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Massaro","sequence":"additional","affiliation":[{"name":"Baim Institute for Clinical Research, Boston, MA (N.C.B., L.M., D.E.C., R.W.Y., W.-H.H., J.M.M.)."},{"name":"Boston University School of Public Health, MA (J.M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mauri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (N.C.B., L.M.)."},{"name":"Harvard Medical School, Boston, MA (N.C.B., L.M., D.E.C., R.W.Y.)."},{"name":"Baim Institute for Clinical Research, Boston, MA (N.C.B., L.M., D.E.C., R.W.Y., W.-H.H., J.M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the DAPT Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-04-0355"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-012-0808-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31823ac046"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409312"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.076"},{"key":"e_1_3_3_7_2","first-page":"897","article-title":"An updated bleeding model to predict the risk of post-procedure bleeding among patients undergoing percutaneous coronary intervention: a report using an expanded bleeding definition from the National Cardiovascular Data Registry CathPCI Registry.","volume":"6","author":"Rao SV","year":"2013","unstructured":"Rao, SV, McCoy, LA, Spertus, JA, Krone, RJ, Singh, M, Fitzgerald, S, Peterson, ED. 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