{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:03:05Z","timestamp":1777071785245,"version":"3.51.4"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>The applicability of Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery scores to left main coronary artery disease (CAD) has been questioned. A simplified alternative is needed for guiding decision making.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We evaluated the prognostic value of a simplified angiographic classification in comparison with a Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery score\u2013based approach for patients with left main CAD undergoing drug-eluting stent implantation. The proposed approach classified left main CAD as either extensive (n=819), defined as left main bifurcation lesions with an involvement of ostial left circumflex artery or as any left main lesion plus multivessel CAD, or limited (n=453), defined as ostial\/midshaft lesions or left main bifurcation lesions without an involvement of ostium of left circumflex artery, alone or plus 1-vessel disease. The databases from 4 prospective Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease studies were pooled, and the primary outcome was a major adverse cardiac event, defined as death, myocardial infarction, or repeat revascularization. During follow-up (median 38 months; interquartile range, 36\u201361 months), the risk for major adverse cardiac event was significantly higher with extensive than with limited left main CAD (adjusted hazard ratio, 2.13; 95% confidence interval, 1.54\u22122.94;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The risk for a composite outcome of death or myocardial infarction was also higher with extensive left main CAD (adjusted hazard ratio, 1.75; 95% confidence interval, 1.08\u22122.85;\n              <jats:italic>P<\/jats:italic>\n              =0.02). However, Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery score tertiles did not effectively stratify these 2 outcome measures.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Compared with Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery scores, the simpler angiographic approach provided better discrimination for future cardiovascular events in patients with left main CAD undergoing drug-eluting stent implantation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.117.005374","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T01:35:21Z","timestamp":1515461721000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of a Simple Angiographic Approach With a Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery Score\u2013Based Approach for Left Main Coronary Artery Stenting"],"prefix":"10.1161","volume":"11","author":[{"given":"Pil Hyung","family":"Lee","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (P.H.L., C.W.L., J.-M.A., D.-W.P., S.-J.K., S.-W.L., Y.-H.K., S.-W.P., S.-J.P.) and Department of Clinical Epidemiology and Biostatistics (S.-O.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (J.-Y.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (P.H.L., C.W.L., J.-M.A., D.-W.P., S.-J.K., S.-W.L., Y.-H.K., S.-W.P., S.-J.P.) and Department of Clinical Epidemiology and Biostatistics (S.-O.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (J.-Y.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol Whan","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (P.H.L., C.W.L., J.-M.A., D.-W.P., S.-J.K., S.-W.L., Y.-H.K., S.-W.P., S.-J.P.) and Department of Clinical Epidemiology and Biostatistics (S.-O.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (J.-Y.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon-Ok","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (P.H.L., C.W.L., J.-M.A., D.-W.P., S.-J.K., S.-W.L., Y.-H.K., S.-W.P., S.-J.P.) and Department of Clinical Epidemiology and Biostatistics (S.-O.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (J.-Y.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (P.H.L., C.W.L., J.-M.A., D.-W.P., S.-J.K., S.-W.L., Y.-H.K., S.-W.P., S.-J.P.) and Department of Clinical Epidemiology and Biostatistics (S.-O.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (J.-Y.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duk-Woo","family":"Park","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (P.H.L., C.W.L., J.-M.A., D.-W.P., S.-J.K., S.-W.L., Y.-H.K., S.-W.P., S.-J.P.) and Department of Clinical Epidemiology and Biostatistics (S.-O.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (J.-Y.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Jin","family":"Kang","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (P.H.L., C.W.L., J.-M.A., D.-W.P., S.-J.K., S.-W.L., Y.-H.K., S.-W.P., S.-J.P.) and Department of Clinical Epidemiology and Biostatistics (S.-O.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (J.-Y.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Whan","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (P.H.L., C.W.L., J.-M.A., D.-W.P., S.-J.K., S.-W.L., Y.-H.K., S.-W.P., S.-J.P.) and Department of Clinical Epidemiology and Biostatistics (S.-O.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (J.-Y.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Hak","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (P.H.L., C.W.L., J.-M.A., D.-W.P., S.-J.K., S.-W.L., Y.-H.K., S.-W.P., S.-J.P.) and Department of Clinical Epidemiology and Biostatistics (S.-O.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (J.-Y.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Wook","family":"Park","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (P.H.L., C.W.L., J.-M.A., D.-W.P., S.-J.K., S.-W.L., Y.-H.K., S.-W.P., S.-J.P.) and Department of Clinical Epidemiology and Biostatistics (S.-O.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; and Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea (J.-Y.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Jung","family":"Park","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Department of Internal Medicine (P.H.L., C.W.L., J.-M.A., D.-W.P., S.-J.K., S.-W.L., Y.-H.K., S.-W.P., S.-J.P.) and Department of Clinical Epidemiology and Biostatistics (S.-O.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 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