{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:37:01Z","timestamp":1778917021756,"version":"3.51.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>In-hospital bleeding after percutaneous coronary intervention is associated with increased mortality. We studied the impact of bleeding severity, defined as magnitude of Hgb (hemoglobin) reduction from baseline (\u0394Hgb), on the risk of death and other adverse events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We studied the association between \u0394Hgb, baseline characteristics, and outcomes among 7608 patients in the ADAPT-DES registry (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) who had information on Hgb values before and after they underwent successful percutaneous coronary intervention. Post-percutaneous coronary intervention, 5985 (78.7%) patients had a drop in Hgb, with 2684 patients (35.3%) having a \u0394Hgb &lt;1.0 g\/dL, 2338 (30.7%) \u22651.0 to &lt;2.0 g\/dL, 745 (9.8%) \u22652.0 to &lt;3.0 g\/dL, 145 (1.9%) \u22653.0 to &lt;4.0 g\/dL, and 73 (1.0%) \u22654.0 g\/dL. The risk of dying within 2 years was 3.3% with &lt;1.0 g\/dL \u0394Hgb, 3.4% with \u0394Hgb \u22651.0 to &lt;2.0 g\/dL, 3.7% with \u0394Hgb \u22652.0 to &lt;3.0 g\/dL, 4.1% with \u0394Hgb \u22653.0 to &lt;4.0 g\/dL, and 9.8% with \u0394Hgb \u22654.0 g\/dL (\n              <jats:italic>P<\/jats:italic>\n              =0.03). The risk of major adverse cardiac events (defined as cardiac death, myocardial infarction, or stent thrombosis) was higher for patients with \u0394Hgb \u22654.0 g\/dL (adjusted hazard ratio, 3.39; 95% confidence interval, 1.97\u20135.83;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and for patients with \u0394Hgb \u22653.0 to &lt;4.0 g\/dL (adjusted hazard ratio, 2.17; 95% confidence interval, 1.34\u20133.53;\n              <jats:italic>P<\/jats:italic>\n              =0.002).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Among patients who undergo successful percutaneous coronary intervention, bleeding events that result in \u0394Hgb \u22654.0 g\/dL are associated with a considerably increased risk of dying.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT00638794.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.117.005542","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T09:10:17Z","timestamp":1521191417000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Bleeding Severity After Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"11","author":[{"given":"Bj\u00f6rn","family":"Redfors","sequence":"first","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (B.R., P.G., A.J.K., T.M., G.W., A.M., R.M., G.W.S.); Sahlgrenska University Hospital, Gothenburg, Sweden (B.R.); Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (P.G.); H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Qu\u00e9bec, Canada (P.G.); Department of Cardiology and Pneumology, Helios Amper-Klinikum, Dachau, Germany (B.W.); Center for Interventional Vascular Therapy, NewYork\u2013Presbyterian Hospital\/Columbia..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"G\u00e9n\u00e9reux","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (B.R., P.G., A.J.K., T.M., G.W., A.M., R.M., G.W.S.); Sahlgrenska University Hospital, Gothenburg, Sweden (B.R.); Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (P.G.); H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Qu\u00e9bec, Canada (P.G.); Department of Cardiology and Pneumology, Helios Amper-Klinikum, Dachau, Germany (B.W.); Center for Interventional Vascular Therapy, NewYork\u2013Presbyterian Hospital\/Columbia..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Witzenbichler","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (B.R., P.G., A.J.K., T.M., G.W., A.M., R.M., G.W.S.); Sahlgrenska University Hospital, Gothenburg, Sweden (B.R.); Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (P.G.); H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Qu\u00e9bec, Canada (P.G.); Department of Cardiology and Pneumology, Helios Amper-Klinikum, Dachau, Germany (B.W.); Center for Interventional Vascular Therapy, NewYork\u2013Presbyterian Hospital\/Columbia..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay J.","family":"Kirtane","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (B.R., P.G., A.J.K., T.M., G.W., A.M., R.M., G.W.S.); Sahlgrenska University Hospital, Gothenburg, Sweden (B.R.); Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (P.G.); H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Qu\u00e9bec, Canada (P.G.); Department of Cardiology and Pneumology, Helios Amper-Klinikum, Dachau, Germany (B.W.); Center for Interventional Vascular Therapy, NewYork\u2013Presbyterian Hospital\/Columbia..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"McAndrew","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (B.R., P.G., A.J.K., T.M., G.W., A.M., R.M., G.W.S.); Sahlgrenska University Hospital, Gothenburg, Sweden (B.R.); Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (P.G.); H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Qu\u00e9bec, Canada (P.G.); Department of Cardiology and Pneumology, Helios Amper-Klinikum, Dachau, Germany (B.W.); Center for Interventional Vascular Therapy, NewYork\u2013Presbyterian Hospital\/Columbia..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giora","family":"Weisz","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (B.R., P.G., A.J.K., T.M., G.W., A.M., R.M., G.W.S.); Sahlgrenska University Hospital, Gothenburg, Sweden (B.R.); Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (P.G.); H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Qu\u00e9bec, Canada (P.G.); Department of Cardiology and Pneumology, Helios Amper-Klinikum, Dachau, Germany (B.W.); Center for Interventional Vascular Therapy, NewYork\u2013Presbyterian Hospital\/Columbia..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Stuckey","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (B.R., P.G., A.J.K., T.M., G.W., A.M., R.M., G.W.S.); Sahlgrenska University Hospital, Gothenburg, Sweden (B.R.); Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (P.G.); H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Qu\u00e9bec, Canada (P.G.); Department of Cardiology and Pneumology, Helios Amper-Klinikum, Dachau, Germany (B.W.); Center for Interventional Vascular Therapy, NewYork\u2013Presbyterian Hospital\/Columbia..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy D.","family":"Henry","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (B.R., P.G., A.J.K., T.M., G.W., A.M., R.M., G.W.S.); Sahlgrenska University Hospital, Gothenburg, Sweden (B.R.); Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (P.G.); H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Qu\u00e9bec, Canada (P.G.); Department of Cardiology and Pneumology, Helios Amper-Klinikum, Dachau, Germany (B.W.); Center for Interventional Vascular Therapy, NewYork\u2013Presbyterian Hospital\/Columbia..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Maehara","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (B.R., P.G., A.J.K., T.M., G.W., A.M., R.M., G.W.S.); Sahlgrenska University Hospital, Gothenburg, Sweden (B.R.); Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (P.G.); H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Qu\u00e9bec, Canada (P.G.); Department of Cardiology and Pneumology, Helios Amper-Klinikum, Dachau, Germany (B.W.); Center for Interventional Vascular Therapy, NewYork\u2013Presbyterian Hospital\/Columbia..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"From the Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (B.R., P.G., A.J.K., T.M., G.W., A.M., R.M., G.W.S.); Sahlgrenska University Hospital, Gothenburg, Sweden (B.R.); Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (P.G.); H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Qu\u00e9bec, Canada (P.G.); Department of Cardiology and Pneumology, Helios Amper-Klinikum, Dachau, 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