{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:38:42Z","timestamp":1791491922269,"version":"4.3.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Percutaneous closure of prosthetic mitral valve paravalvular leak (PVL) has emerged as an alternative to surgical treatment in high-risk patients. Limited data exist on the impact of successful percutaneous PVL closure on midterm outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              We examined consecutive patients who underwent percutaneous mitral PVL closure at Mayo Clinic, Rochester, MN, between January 2006 and January 2017. Procedural success, in-hospital outcomes, and midterm mortality were assessed. A total of 231 patients underwent percutaneous mitral PVL repair at a mean age of 67\u00b112 years. Mean time from mitral valve replacement to percutaneous PVL repair was 1.25 (0.31\u20137.25) years. One hundred sixty-two patients (70%) had \u2264mild PVL after the procedure. Compared with those who had &gt;mild residual PVL, patients with \u2264mild residual PVL had lower rates of repeat surgical interventions (6% versus 17%;\n              <jats:italic>P<\/jats:italic>\n              =0.004) and lower all-cause mortality at 30 days (1% versus 14%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and 1 year (15% versus 39%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Survival at 3 years was 61% in patients who had \u2264mild residual leak and 47% in patients with higher grade of residual PVL (\n              <jats:italic>P<\/jats:italic>\n              =0.002).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In a large consecutive cohort of patients undergoing percutaneous mitral PVL closure, successful percutaneous reduction of the PVL to mild or less was associated with significant midterm survival benefit.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.117.005730","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T01:10:53Z","timestamp":1513386653000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["Successful Percutaneous Mitral Paravalvular Leak Closure Is Associated With Improved Midterm Survival"],"prefix":"10.1161","volume":"10","author":[{"given":"Mohamad","family":"Alkhouli","sequence":"first","affiliation":[{"name":"From the Department of Cardiovascular Diseases (M.A., C.J.Z., M.S., M.F.E., G.S.R., J.F.M., V.T.N., C.S.R.), Division of Pediatrics (A.K.C.), and Division of Pediatric Cardiology, Department of Cardiovascular Diseases (D.J.H.), Mayo Clinic College of Medicine, Rochester, MN; and Division of Cardiovascular Diseases, Department of Medicine, West Virginia University, Morgantown (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad J.","family":"Zack","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Diseases (M.A., C.J.Z., M.S., M.F.E., G.S.R., J.F.M., V.T.N., C.S.R.), Division of Pediatrics (A.K.C.), and Division of Pediatric Cardiology, Department of Cardiovascular Diseases (D.J.H.), Mayo Clinic College of Medicine, Rochester, MN; and Division of Cardiovascular Diseases, Department of Medicine, West Virginia University, Morgantown (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sarraf","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Diseases (M.A., C.J.Z., M.S., M.F.E., G.S.R., J.F.M., V.T.N., C.S.R.), Division of Pediatrics (A.K.C.), and Division of Pediatric Cardiology, Department of Cardiovascular Diseases (D.J.H.), Mayo Clinic College of Medicine, Rochester, MN; and Division of Cardiovascular Diseases, Department of Medicine, West Virginia University, Morgantown (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackram F.","family":"Eleid","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Diseases (M.A., C.J.Z., M.S., M.F.E., G.S.R., J.F.M., V.T.N., C.S.R.), Division of Pediatrics (A.K.C.), and Division of Pediatric Cardiology, Department of Cardiovascular Diseases (D.J.H.), Mayo Clinic College of Medicine, Rochester, MN; and Division of Cardiovascular Diseases, Department of Medicine, West Virginia University, Morgantown (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison K.","family":"Cabalka","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Diseases (M.A., C.J.Z., M.S., M.F.E., G.S.R., J.F.M., V.T.N., C.S.R.), Division of Pediatrics (A.K.C.), and Division of Pediatric Cardiology, Department of Cardiovascular Diseases (D.J.H.), Mayo Clinic College of Medicine, Rochester, MN; and Division of Cardiovascular Diseases, Department of Medicine, West Virginia University, Morgantown (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy S.","family":"Reeder","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Diseases (M.A., C.J.Z., M.S., M.F.E., G.S.R., J.F.M., V.T.N., C.S.R.), Division of Pediatrics (A.K.C.), and Division of Pediatric Cardiology, Department of Cardiovascular Diseases (D.J.H.), Mayo Clinic College of Medicine, Rochester, MN; and Division of Cardiovascular Diseases, Department of Medicine, West Virginia University, Morgantown (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Hagler","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Diseases (M.A., C.J.Z., M.S., M.F.E., G.S.R., J.F.M., V.T.N., C.S.R.), Division of Pediatrics (A.K.C.), and Division of Pediatric Cardiology, Department of Cardiovascular Diseases (D.J.H.), Mayo Clinic College of Medicine, Rochester, MN; and Division of Cardiovascular Diseases, Department of Medicine, West Virginia University, Morgantown (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Maalouf","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Diseases (M.A., C.J.Z., M.S., M.F.E., G.S.R., J.F.M., V.T.N., C.S.R.), Division of Pediatrics (A.K.C.), and Division of Pediatric Cardiology, Department of Cardiovascular Diseases (D.J.H.), Mayo Clinic College of Medicine, Rochester, MN; and Division of Cardiovascular Diseases, Department of Medicine, West Virginia University, Morgantown (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuyisile T.","family":"Nkomo","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Diseases (M.A., C.J.Z., M.S., M.F.E., G.S.R., J.F.M., V.T.N., C.S.R.), Division of Pediatrics (A.K.C.), and Division of Pediatric Cardiology, Department of Cardiovascular Diseases (D.J.H.), Mayo Clinic College of Medicine, Rochester, MN; and Division of Cardiovascular Diseases, Department of Medicine, West Virginia University, Morgantown (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charanjit S.","family":"Rihal","sequence":"additional","affiliation":[{"name":"From the Department of Cardiovascular Diseases (M.A., C.J.Z., M.S., M.F.E., G.S.R., J.F.M., V.T.N., C.S.R.), Division of Pediatrics (A.K.C.), and Division of Pediatric Cardiology, Department of Cardiovascular Diseases (D.J.H.), Mayo Clinic College of Medicine, Rochester, MN; and Division of Cardiovascular Diseases, Department of Medicine, West Virginia University, Morgantown (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00358-9"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.11.1316"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.03.104"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12298"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/5.suppl_D.73"},{"key":"e_1_3_2_7_2","first-page":"160","article-title":"Reoperation for aortic valve periprosthetic leakage: identification of patients at risk and results of operation.","volume":"4","author":"Miller DL","year":"1995","unstructured":"Miller DL, Morris JJ, Schaff HV, Mullany CJ, Nishimura RA, Orszulak TA. 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