{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:46:50Z","timestamp":1791312410800,"version":"4.3.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In the large-scale ADAPT-DES study (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents), drug-eluting stent implantation with intravascular ultrasound (IVUS) guidance was associated with a reduction in 1-year rates of stent thrombosis, myocardial infarction (MI), and major adverse cardiac events (cardiac death, MI, or stent thrombosis) compared with angiography guidance alone. We assessed whether the benefits of IVUS guidance were maintained, reduced, or increased at 2 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      ADAPT-DES was a prospective, multicenter, nonrandomized all-comers study of 8582 consecutive patients at 11 US and German sites designed to determine the frequency, timing, and correlates of adverse events after drug-eluting stents. Propensity-adjusted multivariable analysis was performed to examine the impact of IVUS guidance on 2-year outcomes. IVUS guidance (n=3361; 39%) compared with angiography guidance (n=5221; 61%) was associated with reduced 2-year adjudicated rates of (1) major adverse cardiac events (cardiac death, MI, or stent thrombosis; 4.9% versus 7.5%; adjusted hazard ratio, 0.72; 95% CI, 0.59\u20130.89;\n                      <jats:italic>P<\/jats:italic>\n                      =0.003), (2) definite\/probable stent thrombosis (0.55% versus 1.16%; adjusted hazard ratio, 0.40; 95% CI, 0.22\u20130.73;\n                      <jats:italic>P<\/jats:italic>\n                      =0.003), and (3) MI (3.5% versus 5.6%; adjusted hazard ratio, 0.65; 95% CI, 0.51\u20130.83;\n                      <jats:italic>P<\/jats:italic>\n                      =0.0006). By landmark analysis, IVUS guidance compared with angiography guidance was also associated with significantly reduced rates of major adverse cardiac events, MI, stent thrombosis, and clinically driven target lesion revascularization between 1 and 2 years after drug-eluting stent implantation. The number needed to treat with IVUS guidance to prevent 1 major adverse cardiac event was reduced from 64 (42\u2013137) at 1 year to 41 (29\u201369) at 2 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In ADAPT-DES, the early improvement in event-free survival after drug-eluting stent implantation with IVUS guidance compared with angiography guidance was further increased with longer term follow-up to 2 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      . Unique identifier: NCT00638794.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.117.006243","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T13:01:13Z","timestamp":1546866073000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Relationship Between Intravascular Ultrasound Guidance and Clinical Outcomes After Drug-Eluting Stents"],"prefix":"10.1161","volume":"11","author":[{"given":"Akiko","family":"Maehara","sequence":"first","affiliation":[{"name":"Center for Interventional Vascular Therapy, Division of Cardiology, NewYork\u2013Presbyterian Hospital, Columbia University Medical Center, New York, NY (A.M., A.J.K., G.W.S.)."},{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.M., G.S.M., G.W., T.M., P.G., R.M., A.J.K., G.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Mintz","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.M., G.S.M., G.W., T.M., P.G., R.M., A.J.K., G.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Witzenbichler","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, Helios Amper-Klinikum, Dachau, Germany (B.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giora","family":"Weisz","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.M., G.S.M., G.W., T.M., P.G., R.M., A.J.K., G.W.S.)."},{"name":"Montefiore Medical Center, Bronx, NY (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz-Josef","family":"Neumann","sequence":"additional","affiliation":[{"name":"Universit\u00e4ts-Herzzentrum Freibrug Bad Krozingen, Germany (F.-J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Sanger Heart &amp; Vascular Institute, Carolinas HealthCare System, Charlotte, NC (M.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Christopher","family":"Metzger","sequence":"additional","affiliation":[{"name":"Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Henry","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Heart Institute, Los Angeles, CA (T.D.H.)."},{"name":"Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Cox","sequence":"additional","affiliation":[{"name":"CVA Brookwood Baptist Hospital, Birmingham, AL (D.A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R.","family":"Brodie","sequence":"additional","affiliation":[{"name":"LeBauer-Brodie Center for Cardiovascular Research and Education, Cone Health, Greensboro, NC (B.R.B., T.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Stuckey","sequence":"additional","affiliation":[{"name":"LeBauer-Brodie Center for Cardiovascular Research and Education, Cone Health, Greensboro, NC (B.R.B., T.D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Ernest L.","family":"Mazzaferri","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center, Columbus (E.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"McAndrew","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.M., G.S.M., G.W., T.M., P.G., R.M., A.J.K., G.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"G\u00e9n\u00e9reux","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.M., G.S.M., G.W., T.M., P.G., R.M., A.J.K., G.W.S.)."},{"name":"Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (P.G.)."},{"name":"H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Qu\u00e9bec, Canada (P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.M., G.S.M., G.W., T.M., P.G., R.M., A.J.K., G.W.S.)."},{"name":"The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay J.","family":"Kirtane","sequence":"additional","affiliation":[{"name":"Center for Interventional Vascular Therapy, Division of Cardiology, NewYork\u2013Presbyterian Hospital, Columbia University Medical Center, New York, NY (A.M., A.J.K., G.W.S.)."},{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.M., G.S.M., G.W., T.M., P.G., R.M., A.J.K., G.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"Center for Interventional Vascular Therapy, Division of Cardiology, NewYork\u2013Presbyterian Hospital, Columbia University Medical Center, New York, NY (A.M., A.J.K., G.W.S.)."},{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.M., G.S.M., G.W., T.M., P.G., R.M., A.J.K., G.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003942"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.15454"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61170-8"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.04.036"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.02.008"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I7A129"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.10.002"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.09.013"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.12.043"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-015-0144-8"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.003700"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.04.154"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1004130"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60395-4"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-16-00787"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.003785"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.026788"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002358"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.002447"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-015-0670-4"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.117.006243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:46:14Z","timestamp":1715553974000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.117.006243"}},"subtitle":["Two-Year Follow-Up of the ADAPT-DES Study"],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.117.006243"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.117.006243","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"2017-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006243"}}