{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:29:51Z","timestamp":1789039791013,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background\u2014<\/jats:title>\n                    <jats:p>Invasive physiological assessment of myocardial bridges (MBs) is largely unsettled. Unlike fractional flow reserve (FFR), instantaneous wave\u2013free ratio (iFR) is a diastole-specific index. As such, its value might not be hampered by systolic pressure overshooting and negative systolic pressure gradient caused by the compression of the tunneled coronary artery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results\u2014<\/jats:title>\n                    <jats:p>\n                      We prospectively enrolled 20 patients with angina and\/or positive noninvasive stress test, absence of significant coronary artery stenosis, and angiographic suspicion\/evidence of MB in the left anterior descending artery. According to a prespecified protocol, all patients underwent functional intracoronary evaluation with FFR at rest and after dobutamine (up to 20 \u03bcg kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) and atropine (1 mg) intravenous infusion. iFR at baseline and dobutamine-induced hyperemic wave\u2013free period pressure ratio were also recorded. FFR values \u22640.80 and iFR values \u22640.89 were considered indicative of hemodynamic significance of MB. At baseline, no MB was hemodynamically significant according to FFR, whereas iFR was below the cutoff value in all but 7 patients. During inotropic challenge, median FFR did not change significantly (0.87\u20130.86,\n                      <jats:italic>P<\/jats:italic>\n                      =0.59).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>Physiological evaluation of MBs with iFR seems to be more consistent with patients\u2019 symptoms and noninvasive test results compared with FFR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.117.006247","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T06:11:44Z","timestamp":1528956704000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":90,"title":["Unmasking Myocardial Bridge\u2013Related Ischemia by Intracoronary Functional Evaluation"],"prefix":"10.1161","volume":"11","author":[{"given":"Giuseppe","family":"Tarantini","sequence":"first","affiliation":[{"name":"From the Department of Cardiac, Thoracic and Vascular Sciences, Padova University Hospital, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Barioli","sequence":"additional","affiliation":[{"name":"From the Department of Cardiac, Thoracic and Vascular Sciences, Padova University Hospital, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Nai Fovino","sequence":"additional","affiliation":[{"name":"From the Department of Cardiac, Thoracic and Vascular Sciences, Padova University Hospital, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fraccaro","sequence":"additional","affiliation":[{"name":"From the Department of Cardiac, Thoracic and Vascular Sciences, Padova University Hospital, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Masiero","sequence":"additional","affiliation":[{"name":"From the Department of Cardiac, Thoracic and Vascular Sciences, Padova University Hospital, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabino","family":"Iliceto","sequence":"additional","affiliation":[{"name":"From the Department of Cardiac, Thoracic and Vascular Sciences, Padova University Hospital, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Napodano","sequence":"additional","affiliation":[{"name":"From the Department of Cardiac, Thoracic and Vascular Sciences, Padova University Hospital, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.973"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02768-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.01.085"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0304(199704)40:4<364::AID-CCD9>3.0.CO;2-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.08.013"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.5.1295"},{"key":"e_1_3_2_8_2","first-page":"511","article-title":"Myocardial bridging on the left anterior descending coronary artery and sudden death. 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