{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:55:08Z","timestamp":1781808908304,"version":"3.54.5"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Children treated with cardiac catheterization procedures have now a long life expectancy and consequently potential long-term radiation-induced risks. We projected lifetime attributable risks (LARs) of cancer incidence from the most frequent procedures in pediatrics: atrial septal defect closure, patent ductus arteriosus occlusion, or pulmonary valvuloplasty.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p>Organ equivalent doses were estimated for 1251 procedures performed in children aged \u226415 years at 2 reference catheterization centers in France from 2009 to 2013. Sex-specific LARs were projected in lifelong nonsmokers using extended Committee on Biological Effects of Ionizing Radiation VII risk models and considering various sources of risk projection uncertainties and dose variability (Radiation Risk Assessment Tool software). Median LARs ranged between 0.3 and 1.4 (atrial septal defect closure), 0.6 and 5.0 (patent ductus arteriosus occlusion), and 1.0 and 12.0 (pulmonary valvuloplasty) per 1000 procedures, depending on patient sex and age at treatment. These radiation-related risks would represent 0.4% to 6.0% of children\u2019s total lifetime cancer risk. For the 10% of procedures (all types combined) with highest exposures, LARs reached 4.2 per 1000 (95% uncertainty interval, 0.8\u201313.1) in boys and 22.2 per 1000 (95% uncertainty interval, 7.4\u201345.6) in girls. In boys, lung cancer accounted for 70% to 80% of the projected LARs, whereas in girls it accounted for 20% to 60% and breast cancer for 30% to 80% of the excess risks, depending on the type of procedure and patient age.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Radiation exposure may lead to substantial radiation doses and increased cancer risks in some cases. This suggests the need for dose reporting to support recommendations for long-term surveillance and prevention strategies when it is necessary.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.118.006765","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T18:01:13Z","timestamp":1546884073000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Projected Future Cancer Risks in Children Treated With Fluoroscopy-Guided Cardiac Catheterization Procedures"],"prefix":"10.1161","volume":"11","author":[{"given":"Neige","family":"Journy","sequence":"first","affiliation":[{"name":"Ionizing Radiation Epidemiology Laboratory (LEPID) (N.J., E.R., F.D.Z.-B., D.L., M.-O.B., H.B.)"},{"name":"INSERM Unit 1018, Centre for Research in Epidemiology and Population Health (CESP), Cancer and Radiations group, Gustave Roussy, Villejuif, France (N.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Dreuil","sequence":"additional","affiliation":[{"name":"Medical Radiation Protection Assessment Unit (UEM) (S.D.) and Institute for Radiation Protection and Nuclear Safety (IRSN), Fontenayaux-Roses, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Rage","sequence":"additional","affiliation":[{"name":"Ionizing Radiation Epidemiology Laboratory (LEPID) (N.J., E.R., F.D.Z.-B., D.L., M.-O.B., H.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"De Zordo-Banliat","sequence":"additional","affiliation":[{"name":"Ionizing Radiation Epidemiology Laboratory (LEPID) (N.J., E.R., F.D.Z.-B., D.L., M.-O.B., H.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Department of Congenital and Pediatric Cardiology, Centre de R\u00e9f\u00e9rence des Malformations Cardiaques Cong\u00e9nitales Complexes (M3C), Necker Hospital, APHP, Paris, France (D.B., S.M.-M.)."},{"name":"Paris-Descartes University, Sorbonne Paris Cit\u00e9, France (D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Hasco\u00ebt","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease, Centre de R\u00e9f\u00e9rence des Malformations Cardiaques Cong\u00e9nitales Complexes (M3C), Marie Lannelongue Hospital, Le Plessis-Robinson, France (S.H., J.P.)."},{"name":"INSERM, UMR-S 999, Paris-Sud School of Medicine, Paris-Saclay University, Le Kremlin-Bic\u00eatre, France (S.H., J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Malekzadeh-Milani","sequence":"additional","affiliation":[{"name":"Department of Congenital and Pediatric Cardiology, Centre de R\u00e9f\u00e9rence des Malformations Cardiaques Cong\u00e9nitales Complexes (M3C), Necker Hospital, APHP, Paris, France (D.B., S.M.-M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Petit","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease, Centre de R\u00e9f\u00e9rence des Malformations Cardiaques Cong\u00e9nitales Complexes (M3C), Marie Lannelongue Hospital, Le Plessis-Robinson, France (S.H., J.P.)."},{"name":"INSERM, UMR-S 999, Paris-Sud School of Medicine, Paris-Saclay University, Le Kremlin-Bic\u00eatre, France (S.H., J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Laurier","sequence":"additional","affiliation":[{"name":"Ionizing Radiation Epidemiology Laboratory (LEPID) (N.J., E.R., F.D.Z.-B., D.L., M.-O.B., H.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Bernier","sequence":"additional","affiliation":[{"name":"Ionizing Radiation Epidemiology Laboratory (LEPID) (N.J., E.R., F.D.Z.-B., D.L., M.-O.B., H.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Baysson","sequence":"additional","affiliation":[{"name":"Ionizing Radiation Epidemiology Laboratory (LEPID) (N.J., E.R., F.D.Z.-B., D.L., M.-O.B., H.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","unstructured":"EUROCAT Access Prevalence Tables. 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