{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:13:36Z","timestamp":1780550016221,"version":"3.54.1"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The dual antiplatelet therapy (DAPT) risk score was developed from the DAPT trial to inform the optimal duration of DAPT after percutaneous coronary intervention. We assessed the performance of the DAPT score in the ADAPT-DES (Assessment of Dual AntiPlatelet Therapy with drug-eluting stents) all-comers registry and tested the utility of additional predictors of adverse events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              Outcomes between 1 and 2 years were examined according to DAPT score \u22652 versus &lt;2, adjusted for DAPT continuation as a time-dependent variable. To assess the incremental utility of variables not included in the DAPT score, baseline high platelet reactivity was added to the ischemia model, and high platelet reactivity, baseline hemoglobin, and warfarin use 1 year after percutaneous coronary intervention were added to the bleeding model. Among 8582 patients enrolled in ADAPT-DES, 5397 were event-free after 1 year. Between 1 and 2 years, ischemic (myocardial infarction or stent thrombosis) and bleeding events occurred in 75 (1.5%) and 124 (2.3%) patients, respectively. Patients with higher DAPT scores (\u22652 versus &lt;2) had higher rates of myocardial infarction or stent thrombosis (1.9% versus 1.1%;\n              <jats:italic>P<\/jats:italic>\n              =0.01) and similar rates of bleeding (2.2% versus 2.4%, respectively;\n              <jats:italic>P<\/jats:italic>\n              =0.79). For the prediction of myocardial infarction or stent thrombosis, bleeding and death, DAPT score \u22652 had sensitivities of 57%, 41%, and 56%, respectively; specificities of 58%, 57%, and 58%, respectively; positive predictive values of 1.9%, 2.2%, and 2.1%, respectively; and negative predictive values of 99%, 98%, and 99%, respectively. Addition of baseline high platelet reactivity to the DAPT score did not improve discrimination for ischemic events. Addition of high platelet reactivity and 2 other bleeding covariates to the DAPT score marginally improved discrimination.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In ADAPT-DES, the DAPT score was predictive of ischemic events between 1 and 2 years after drug-eluting stents. Prediction of bleeding improved marginally after addition of variables not incorporated in the DAPT score.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.118.006853","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T09:06:33Z","timestamp":1539335193000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Prediction of Ischemic and Bleeding Events Using the Dual Antiplatelet Therapy Score in an Unrestricted Percutaneous Coronary Intervention Population"],"prefix":"10.1161","volume":"11","author":[{"given":"Sorin J.","family":"Brener","sequence":"first","affiliation":[{"name":"NewYork-Presbyterian Brooklyn Methodist Hospital (S.J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay J.","family":"Kirtane","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital\/Columbia University Medical Center (A.J.K., G.W.S.)."},{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.J.K., G.W., R.M., T.M., G.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Sanger Heart and Vascular Institute, Carolinas HealthCare System, Charlotte, NC (M.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Stuckey","sequence":"additional","affiliation":[{"name":"LeBauer-Brodie Center for Cardiovascular Research and Education\/Cone Health, Greensboro, NC (T.D.S., B.R.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Witzenbichler","sequence":"additional","affiliation":[{"name":"Helios Amper-Klinikum, Dachau, Germany (B.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giora","family":"Weisz","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.J.K., G.W., R.M., T.M., G.W.S.)."},{"name":"Montefiore Medical Center, Bronx, NY (G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz-Josef","family":"Neumann","sequence":"additional","affiliation":[{"name":"Universit\u00e4ts-Herzzentrum Freiburg, Bad Krozingen, Germany (F.-J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Christopher","family":"Metzger","sequence":"additional","affiliation":[{"name":"Wellmont CVA Heart Institute, Kingsport, TN (D.C.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Henry","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, MN (T.D.H.)."},{"name":"Cedars-Sinai Heart Institute, Los Angeles, CA (T.D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Cox","sequence":"additional","affiliation":[{"name":"CVA Brookwood Baptist Hospital, Birmingham, AL (D.A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Reid Heart Center, FirstHealth of the Carolinas, Pinehurst, NC (P.L.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Ernest L.","family":"Mazzaferri","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center, Columbus (E.L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Gurbel","sequence":"additional","affiliation":[{"name":"Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Falls Church, VA (P.A.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R.","family":"Brodie","sequence":"additional","affiliation":[{"name":"LeBauer-Brodie Center for Cardiovascular Research and Education\/Cone Health, Greensboro, NC (T.D.S., B.R.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.J.K., G.W., R.M., T.M., G.W.S.)."},{"name":"The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, NY (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"McAndrew","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.J.K., G.W., R.M., T.M., G.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital\/Columbia University Medical Center (A.J.K., G.W.S.)."},{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (A.J.K., G.W., R.M., T.M., G.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409312"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.3775"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309023291001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61336-1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61170-8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.029165"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062437"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.02.011"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113284"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3287615"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.02.052"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004310"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000018"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp110"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60263-X"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2014.12.002"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028924"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.003"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw683"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500857"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.118.006853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:29:35Z","timestamp":1715567375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.118.006853"}},"subtitle":["Analysis From the ADAPT-DES Registry"],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.118.006853"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.118.006853","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"2018-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006853"}}