{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:57:43Z","timestamp":1785866263004,"version":"3.56.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The basis of discordance between invasive coronary angiographic (ICA) anatomic stenosis and fractional flow reserve (FFR) is not fully understood. We analyzed coronary computed tomography angiography (CTA) characteristics of ICA-verified nonobstructive lesions in the proximal or midleft anterior descending artery with FFR \u22640.8, that is, anatomy-physiology mismatch.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              CTA and ICA were performed in 108 patients. FFR was measured during intravenous ATP (180 \u03bcg\/[kg\u00b7min]) infusion. CTA-verified plaque characteristics between 53 consecutive ICA-FFR mismatch (ICA\u2013quantitative coronary angiography &lt;50%, FFR\u22640.8) and 55 ICA-FFR match (ICA\u2013quantitative coronary angiography&lt;50%, FFR&gt;0.8) vessels were compared. CTA-verified vessel area (20.7\u00b16.7 versus 16.9\u00b14.8 mm\n              <jats:sup>2<\/jats:sup>\n              ;\n              <jats:italic>P<\/jats:italic>\n              =0.0007), positive area remodeling index (ARI; 1.38\u00b10.23 versus 1.06\u00b10.11;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), %plaque area (64.7\u00b112.7 versus 57.4\u00b18.5%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0007), jeopardized myocardial mass (46.2\u00b118.5 versus 37.1\u00b114.3 g;\n              <jats:italic>P<\/jats:italic>\n              = 0.006), and the prevalence of low attenuation plaque (45.3% versus 9.1%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) at the minimum lumen area were significantly higher in the ICA-FFR mismatch than the match group. By receiver operation curve analysis, the areas under the curve for positive area remodeling index, %plaque area and jeopardized myocardial mass were 0.921, 0.681, and 0.641, respectively, for the diagnosis of mismatch (cutoff values 1.13, 66% and 58.7 g, respectively). The sensitivity and specificity of area remodeling index &gt;1.13 for predicting ICA-FFR mismatch were 88.7% and 78.2%, respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In the absence of anatomically significant stenosis, abnormal FFR is more frequently encountered in patients with CTA-derived positive remodeling, larger plaque burden, and low attenuation plaque. These findings contribute to a better understanding of how FFR-based decision-making might translate into demonstrated superior clinical outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.118.006961","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T14:37:50Z","timestamp":1550241470000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":29,"title":["Abnormal Fractional Flow Reserve in Nonobstructive Coronary Artery Disease"],"prefix":"10.1161","volume":"12","author":[{"given":"Shunsuke","family":"Imai","sequence":"first","affiliation":[{"name":"Division of Cardiology, Gifu Heart Center, Japan (S.I., T.K., Y.K., H.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Gifu Heart Center, Japan (S.I., T.K., Y.K., H.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular Research Foundation, New York, NY (G.W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Kawase","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Gifu Heart Center, Japan (S.I., T.K., Y.K., H.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir A.","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.A.A., J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagat","family":"Narula","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.A.A., J.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Gifu Heart Center, Japan (S.I., T.K., Y.K., H.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807611"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.012"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.11.002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.0263"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.11.020"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-17-0122"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705283162204"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.068"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.069"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205361"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408758"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3388-2"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.363"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e3181b66c41"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.09.002"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-0161"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.971101"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005916"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.05.052"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv690"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV11I2A30"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.01.021"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.966"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2016.12.007"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.118.006961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:36:19Z","timestamp":1715567779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.118.006961"}},"subtitle":["The Relationship With Plaque Characteristics"],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.118.006961"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.118.006961","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"2018-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006961"}}