{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:38:32Z","timestamp":1789501112029,"version":"build-2803163510"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Renal disease is associated with poor prognosis despite guideline-directed cardiovascular therapy, and outcomes by sex in this population remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Patients (n=5213) who underwent a MitraClip procedure in the National Cardiovascular Data Registry Transcatheter Valve Therapy registry were evaluated for the primary composite outcome of all-cause mortality, stroke, and new requirement for dialysis by creatinine clearance (CrCl). Centers for Medicare and Medicaid Services\u2013linked data were available in 63% of patients (n=3300). CrCl was &lt;60 mL\/min in 77% (n=4010) and &lt;30 mL\/min in 23% (n=1183) of the cohort. Rates of primary outcome were higher with lower CrCl (&gt;60 mL\/min, 1.4%; 30\u2013&lt;60 mL\/min, 2.7%; &lt;30 mL\/min, 5.2%; dialysis, 7.8%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), and all low CrCl groups were independently associated with the primary outcome (30\u2013&lt;60 mL\/min: adjusted odds ratio, 2.32; 95% CI, 1.38\u20133.91; &lt;30 mL\/min: adjusted odds ratio, 4.44; 95% CI, 2.63\u20137.49; dialysis: adjusted hazards ratio, 4.52; 95% CI, 2.08\u20139.82) when compared with CrCl &gt;60 mL\/min. Rates of 1-year mortality were higher with lower CrCl (&gt;60 mL\/min, 13.2%; 30\u2013&lt;60 mL\/min, 18.8%; &lt;30 mL\/min, 29.9%; dialysis, 32.3%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), and all low CrCl groups were independently associated with 1-year mortality (30\u2013&lt;60 mL\/min: adjusted hazards ratio, 1.50; 95% CI, 1.13\u20131.99; &lt;30 mL\/min: adjusted hazards ratio, 2.38; 95% CI, 1.78\u20133.20; adjusted hazards ratio: dialysis, 2.44; 95% CI, 1.66\u20133.57) when compared with CrCl &gt;60 mL\/min.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The majority of patients who undergo MitraClip have renal disease. Preprocedural renal disease is associated with poor outcomes, particularly in stage 4 or 5 renal disease where 1-year mortality is observed in nearly one-third. Studies to determine how to further optimize outcomes in this population are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.118.007552","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T05:07:12Z","timestamp":1548997632000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Outcomes After Transcatheter Mitral Valve Repair in Patients With Renal Disease"],"prefix":"10.1161","volume":"12","author":[{"given":"Binita","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Medicine (Cardiology), VA New York Harbor Healthcare System (Manhattan Campus) and New York University School of Medicine (B.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"Villablanca","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) (P.A.V., N.S.A., M.S., C.S.), New York University 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