{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:54:51Z","timestamp":1787064891144,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We aimed to compare the rate of neurological events in patients with or without cerebral embolic protection (CEP) during transcatheter aortic valve replacement (TAVR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      Data on clinical end points including neurological events \u226430 days post-TAVR were collected for all patients who underwent transfemoral TAVR in 2 academic tertiary care institutions. Patients were matched through propensity scoring, which resulted in 333 pairs of patients with versus without CEP out of a total of 831 consecutive patients. The median age was 81 (76\u201385) years, and the median logistic EuroScore was 14% (9%\u201320%). The CEP group experienced less neurological events at 24 hours (1% versus 4%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.035) and at 30 days (3% versus 7%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.029). There were significantly more disabling strokes in unprotected patients at 30 days (1% versus 4%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.039). CEP was associated with significantly fewer neurological events at 24 hours after TAVR (odds ratio, 0.20; 95% CI, 0.06\u20130.73;\n                      <jats:italic>P<\/jats:italic>\n                      =0.015) by multiple regression analysis, while age and valve type did not contribute significantly. Overall, 67% (2 of 3) in the CEP versus 83% (10 of 12) in the non-CEP cohort experienced neurological events in protected areas (ie, not dependent on the left vertebral artery).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The use of filter-based CEP during TAVR was associated with less neurological events, especially in CEP-protected brain territories.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.118.007605","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T05:00:25Z","timestamp":1560488425000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Early Clinical Impact of Cerebral Embolic Protection in Patients Undergoing Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"12","author":[{"given":"Herbert G.","family":"Kroon","sequence":"first","affiliation":[{"name":"Department of Cardiology (H.G.K., L.v.G., F.R.v.d.B., N.E.F., Z.R., J.D., P.d.J., N.M.V.M.), Erasmus University Medical Center, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hindrik W.","family":"van der Werf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, the Netherlands (H.W.v.d.W., R.A.J.S., A.v.d.H., P.v.d.H., J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne E.","family":"Hoeks","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology\/Epidemiology (S.E.H.), Erasmus University Medical Center, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"van Gils","sequence":"additional","affiliation":[{"name":"Department of Cardiology (H.G.K., L.v.G., F.R.v.d.B., N.E.F., Z.R., J.D., P.d.J., N.M.V.M.), Erasmus University Medical Center, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fauve R.","family":"van den Berge","sequence":"additional","affiliation":[{"name":"Department of Cardiology (H.G.K., L.v.G., F.R.v.d.B., N.E.F., Z.R., J.D., P.d.J., N.M.V.M.), Erasmus University Medical Center, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"El Faquir","sequence":"additional","affiliation":[{"name":"Department of Cardiology (H.G.K., L.v.G., F.R.v.d.B., N.E.F., Z.R., J.D., P.d.J., N.M.V.M.), Erasmus University Medical Center, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zouhair","family":"Rahhab","sequence":"additional","affiliation":[{"name":"Department of Cardiology (H.G.K., L.v.G., F.R.v.d.B., N.E.F., Z.R., J.D., P.d.J., N.M.V.M.), Erasmus University Medical Center, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[{"name":"Department of Cardiology (H.G.K., L.v.G., F.R.v.d.B., N.E.F., Z.R., J.D., P.d.J., N.M.V.M.), Erasmus University Medical Center, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janny","family":"Poelman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, the Netherlands (H.W.v.d.W., R.A.J.S., A.v.d.H., P.v.d.H., J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco A.J.","family":"Schurer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, the Netherlands (H.W.v.d.W., R.A.J.S., A.v.d.H., P.v.d.H., J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad","family":"van den Heuvel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, the Netherlands (H.W.v.d.W., R.A.J.S., A.v.d.H., P.v.d.H., J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"de Jaegere","sequence":"additional","affiliation":[{"name":"Department of Cardiology (H.G.K., L.v.G., F.R.v.d.B., N.E.F., Z.R., J.D., P.d.J., N.M.V.M.), Erasmus University Medical Center, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"van der Harst","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Groningen, the Netherlands (H.W.v.d.W., R.A.J.S., A.v.d.H., P.v.d.H., J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas M.","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Department of Cardiology (H.G.K., L.v.G., F.R.v.d.B., N.E.F., Z.R., J.D., P.d.J., N.M.V.M.), Erasmus University Medical Center, Rotterdam, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700456"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.110981"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.01.020"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV12I4A84"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.023"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.10302"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.06.037"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.12.002"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.001"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4200"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.022"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I1A20"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27323"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.118.007605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T22:38:14Z","timestamp":1715553494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.118.007605"}},"subtitle":["A Two-Center Registry in the Netherlands"],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.118.007605"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.118.007605","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"2018-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e007605"}}