{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:04:02Z","timestamp":1757451842584,"version":"3.41.2"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Data examining the impact of diabetes mellitus (DM) on ischemic risk after percutaneous coronary intervention in women are limited as most clinical trial participants are male. We evaluated (1) the impact of DM on ischemic outcomes in women undergoing drug-eluting stent (DES) implantation and (2) whether the outcomes of new- versus early-generation DES vary by DM status.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              We pooled patient-level data of 10 448 women undergoing percutaneous coronary intervention with DES from 26 randomized trials. Baseline characteristics and 3-year clinical outcomes were stratified according to DM status (noninsulin-dependent and insulin-dependent) and DES generation. The primary end point was the composite of all-cause death or myocardial infarction. Secondary end points were definite or probable stent thrombosis and target lesion revascularization. Compared with women without DM (n=7154, 68.5%), adjusted risks (adjusted hazard ratios [95% CI]) for death or myocardial infarction among women with noninsulin-dependent DM (n=2241, 21.4%) and insulin-dependent DM (n=1053, 10.1%) were 1.30 (1.11\u20131.53) and 1.71 (1.41\u20132.07), respectively (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              &lt;0.001). Similar trends were observed for def\/prob stent thrombosis and target lesion revascularization. Compared with early-generation DES, use of newer-generation DES was associated with significant reductions in death or myocardial infarction in the absence of DM whereas differences were nonsignificant in the presence of DM, with similar findings for def\/prob stent thrombosis and target lesion revascularization.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The presence of DM is associated with substantial, graded, and durable risks for ischemic events among women undergoing percutaneous coronary intervention with DES. The safety and efficacy profile of newer-generation DES is preserved among women without DM, while benefits are nonsignificant among women with DM.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.118.007734","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T09:00:35Z","timestamp":1562749235000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Diabetes Mellitus in Women Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents"],"prefix":"10.1161","volume":"12","author":[{"given":"Usman","family":"Baber","sequence":"first","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York City (U.B., G.G., S.S., M.A., G.D.D., R.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio G.","family":"Stefanini","sequence":"additional","affiliation":[{"name":"Humanitas Research Hospital, Rozzano, Milan, Italy (G.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro","family":"Giustino","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York City (U.B., G.G., S.S., M.A., G.D.D., R.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York City (G.W.S., M.B.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York City (G.W.S., M.B.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Sartori","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York City (U.B., G.G., S.S., M.A., G.D.D., R.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Aquino","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York City (U.B., G.G., S.S., M.A., G.D.D., R.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"D\u00e9partement Hospitalo Universitaire Fibrose, Inflammation et REmodelage, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Paris Diderot, INSERM U1148, Paris, France (P.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"Bern University Hospital, Bern, Switzerland (S.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Wijns","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Aalst, Onze-Lieve\u2013Vrouwziekenhuis Ziekenhuis, Aalst, Belgium (W.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick W.","family":"Serruys","sequence":"additional","affiliation":[{"name":"ErasmusMC, Rotterdam, the Netherlands (P.W.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Valgimigli","sequence":"additional","affiliation":[{"name":"University of Ferrara, Italy (M.V.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2013Claude","family":"Morice","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Surgery, Institut Cardiovasculaire Paris Sud, France (M.-C.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Camenzind","sequence":"additional","affiliation":[{"name":"Institut Lorrain du Coeur et des Vaisseaux (ILCV) University Hospital Nancy\u2013Brabois Vandoeuvre-l\u00e8s- Nancy France (E.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giora","family":"Weisz","sequence":"additional","affiliation":[{"name":"Shaare Zedek Medical Center, Jerusalem, Israel and Columbia University Medical Center, NY (G.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter C.","family":"Smits","sequence":"additional","affiliation":[{"name":"Maasstad Hospital, Rotterdam, the Netherlands (P.C.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Kandzari","sequence":"additional","affiliation":[{"name":"Piedmont Heart Institute, Atlanta, GA (D.E.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"von Birgelen","sequence":"additional","affiliation":[{"name":"Thoraxcentrum Twente, Enschede, the Netherlands (C.v.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George D.","family":"Dangas","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York City (U.B., G.G., S.S., M.A., G.D.D., R.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soren","family":"Galatius","sequence":"additional","affiliation":[{"name":"Bispebjerg University Hospital, Copenhagen, Denmark (S.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raban V.","family":"Jeger","sequence":"additional","affiliation":[{"name":"University Hospital Basel, Switzerland (R.V.J.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Kyoto University Graduate School of Medicine, Japan (T.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada W.","family":"Mikhail","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London (G.W.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipti","family":"Itchhaporia","sequence":"additional","affiliation":[{"name":"Hoag Memorial Hospital Presbyterian, Newport Beach, CA (D.I.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laxmi","family":"Mehta","sequence":"additional","affiliation":[{"name":"Ohio State University Medical Center, Columbus (L.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Ortega","sequence":"additional","affiliation":[{"name":"Society of Cardiovascular Angiography and Interventions, Washington, DC (R.O.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University Main Hospital, Korea (H.-S.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Kastrati","sequence":"additional","affiliation":[{"name":"Herzzentrum, Munich, Germany (A.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaide","family":"Chieffo","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute, Milan, Italy (A.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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