{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:17:48Z","timestamp":1781968668380,"version":"3.54.5"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The risk factors and long-term clinical outcomes of patients with definite stent thrombosis (ST) after second-generation drug-eluting stent (DES) implantation have not yet been adequately assessed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              The REAL-ST (Retrospective Multicenter Registry of ST After First- and Second-Generation DES Implantation) included 313 definite ST of second-generation DES (early ST, n=179; late ST, n=66; very late ST, n=68). Four patients without definite ST of second-generation DES were identified as control patients for each ST case. Risk factors of definite ST were mostly different according to the timing of ST: ST-segment\u2013elevation myocardial infarction, non\u2013ST-segment\u2013elevation myocardial infarction, and unstable angina at presentation, current smoking, left ventricular ejection fraction &lt;40%, prior percutaneous coronary intervention, stent overlap, severely calcified lesion, left main coronary artery lesion, proximal left anterior descending lesion, postdiameter stenosis \u226520%, for early ST; age &lt;70 years, ST-segment\u2013elevation myocardial infarction at presentation, hemodialysis, left ventricular ejection fraction &lt;40%, in-stent restenosis, and severely calcified lesion for late ST; and proximal left anterior descending lesion and in-stent restenosis for very late ST. Cumulative 4-year incidence of death after the index ST events was significantly higher in the ST patients than control patients (33.0% versus 12.3%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for early ST versus control; 30.6% versus 14.2%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for late ST versus control; and 28.0% versus 13.0%,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for very late ST versus control, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Risk factors of definite ST after second-generation DES implantation were mostly different according to the timing of ST. Definite ST patients showed unfavorable long-term clinical outcomes compared with those without definite ST.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.umin.ac.jp\">https:\/\/www.umin.ac.jp<\/jats:ext-link>\n              . Unique identifier: UMIN000025181.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.119.007822","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T09:00:28Z","timestamp":1560157228000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Risk Factors and Long-Term Clinical Outcomes of Second-Generation Drug-Eluting Stent Thrombosis"],"prefix":"10.1161","volume":"12","author":[{"given":"Shoichi","family":"Kuramitsu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan (S.K., K.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Ohya","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kurashiki Central Hospital, Japan (M.O., K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Shinozaki","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, the University of Tokyo, Japan (T.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Otake","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kobe University Graduates School of Medicine, Japan (H.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Sendai Kousei Hospital, Japan (K.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, New Tokyo Hospital, Chiba, Japan (H.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futoshi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, Kanagawa, Japan (F.Y., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Natsuaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Fukuoka General Hospital, Japan (M.N)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan (H.S., T.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Tokai University School of Medicine, Isehara, Japan (G.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan (S.K., K.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushige","family":"Kadota","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kurashiki Central Hospital, Japan (M.O., K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, Kanagawa, Japan (F.Y., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan (H.S., T.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the REAL-ST Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.799403"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.903955"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.06.015"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.113.000412"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.022"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0325-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.016"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.046599"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003942"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-0233"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2017.11.011"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.026788"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv227"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.026047"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.119.007822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:37:59Z","timestamp":1715567879000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.119.007822"}},"subtitle":["Insights From the REAL-ST Registry"],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.119.007822"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.119.007822","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"2018-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e007822"}}