{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:33:32Z","timestamp":1762868012568,"version":"3.41.2"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Intravenous infusion of adenosine is considered standard practice for fractional flow reserve (FFR) assessment but is associated with adverse side-effects and is time-consuming. Intracoronary bolus injection of adenosine is better tolerated by patients, cheaper, and less time-consuming. However, current literature remains fragmented and modestly sized regarding the equivalence of intracoronary versus intravenous adenosine. We aim to investigate the relationship between intracoronary adenosine and intravenous adenosine to determine FFR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We performed a lesion-level meta-analysis to compare intracoronary adenosine with intravenous adenosine (140 \u00b5g\/kg per minute) for FFR assessment. The search was conducted in accordance to the Preferred Reporting for Systematic Reviews and Meta-Analysis statement. Lesion-level data were obtained by contacting the respective authors or by digitization of scatterplots using custom-made software. Intracoronary adenosine dose was defined as; low: &lt;40 \u00b5g, intermediate: 40 to 99 \u00b5g, and high: \u2265100 \u00b5g.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              We collected 1972 FFR measurements (1413 lesions) comparing intracoronary with intravenous adenosine from 16 studies. There was a strong correlation (correlation coefficient =0.915;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) between intracoronary-FFR and intravenous-FFR. Mean FFR was 0.81\u00b10.11 for intracoronary adenosine and 0.81\u00b10.11 for intravenous adenosine (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). We documented a nonclinically relevant mean difference of 0.006 (limits of agreement: \u22120.066 to 0.078) between the methods. When stratified by the intracoronary adenosine dose, mean differences between intracoronary and intravenous-FFR amounted to 0.004, 0.011, or 0.000 FFR units for low-dose, intermediate-dose, and high-dose intracoronary adenosine, respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The present study documents clinically irrelevant differences in FFR values obtained with intracoronary versus intravenous adenosine. Intracoronary adenosine hence confers a practical and patient-friendly alternative for intravenous adenosine for FFR assessment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.119.007893","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T10:00:18Z","timestamp":1577181618000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Individual Lesion-Level Meta-Analysis Comparing Various Doses of Intracoronary Bolus Injection of Adenosine With Intravenous Administration of Adenosine for Fractional Flow Reserve Assessment"],"prefix":"10.1161","volume":"13","author":[{"given":"Gilbert W.M.","family":"Wijntjens","sequence":"first","affiliation":[{"name":"Heart Center (G.W.M.W., E.L.v.U., V.E.S., T.M., J.J.P., T.P.v.d.H.), locatie-AMC, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen L.","family":"van Uffelen","sequence":"additional","affiliation":[{"name":"Heart Center (G.W.M.W., E.L.v.U., V.E.S., T.M., J.J.P., T.P.v.d.H.), locatie-AMC, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Echavarr\u00eda-Pinto","sequence":"additional","affiliation":[{"name":"Hospital General ISSSTE - Facultad de Medicina, Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico (M.E.-P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Casadonte","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and Physics (L.C.), Amsterdam-Universitair Medische Centra, locatie-AMC, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie E.","family":"Stegehuis","sequence":"additional","affiliation":[{"name":"Heart Center (G.W.M.W., E.L.v.U., V.E.S., T.M., J.J.P., T.P.v.d.H.), locatie-AMC, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Murai","sequence":"additional","affiliation":[{"name":"Heart Center (G.W.M.W., E.L.v.U., V.E.S., T.M., J.J.P., T.P.v.d.H.), locatie-AMC, the Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen M.J.","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam-Universitair Medische Centra, locatie VUmc, Amsterdam, the Netherlands (K.M.J.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myeong-Ho","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ajou University, Suwon, Republic of Korea (M.-H.Y., S.-J.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Jea","family":"Tahk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ajou University, Suwon, Republic of Korea (M.-H.Y., S.-J.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Casella","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ospedale Maggiore, Bologna, Italy (G.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio M.","family":"Leone","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy (A.M.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"L\u00f3pez Palop","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario de San Juan de Alicante, San Juan de Alicante, Spain (R.L.-P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schlundt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Erlangen, Germany (C.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Rivero","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario de la Princesa, Universidad Aut\u00f3noma de Madrid, Spain (F.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Petraco","sequence":"additional","affiliation":[{"name":"Imperial College London, United Kingdom (R.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Fearon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Stanford University School of Medicine, Stanford Cardiovascular Institute (W.F.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils P.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Weatherhead PET Center, Division of Cardiology, Department of Medicine, McGovern Medical School at UTHealth and Memorial Hermann Hospital, Houston (N.P.J.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen","family":"Jeremias","sequence":"additional","affiliation":[{"name":"St Francis Hospital, Roslyn, Cardiovascular Research Foundation, New York, NY (A.J.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bon-Kwon","family":"Koo","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine, Republic of Korea 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