{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:23:03Z","timestamp":1765268583525,"version":"3.41.2"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Few studies have compared long-term outcomes among specific treatment modalities for critical limb ischemia. The aim of this study was to compare long-term outcomes with percutaneous transluminal angioplasty (PTA), stent placement, atherectomy, or surgical bypass in patients diagnosed with critical limb ischemia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>In this observational study using Medicare claims data, we identified incident cases with a primary critical limb ischemia diagnosis who received PTA, stent placement, atherectomy, or surgical bypass. We used propensity score weighting to determine the association of treatment type with all-cause mortality and major (above ankle) amputation over 4 years follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Among 36\u2009860 patients (10\u2009904 PTA; 11\u2009295 stent placement; 4422 atherectomy; 10\u2009239 surgical bypass), all-cause mortality over 4 years was 49.3% with atherectomy, 51.4% with surgical bypass, 53.7% with stent placement, and 54.7% with PTA (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05 for all pairwise comparisons). Major amputation rates over 4 years were 6.8% with atherectomy, 7.8% with stent placement, 8.1% with PTA, and 10.8% with surgical bypass (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05 for all pairwise comparison except PTA versus stent).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Among Medicare beneficiaries who received PTA, stent placement, atherectomy, or surgical bypass for critical limb ischemia, high mortality and major amputation rates were observed with minor differences among treatment groups. Statistically significant group differences of uncertain clinical importance were observed for several comparisons. Results from observational research may be susceptible to bias because of unmeasured confounders and, therefore, these comparative results should be interpreted with caution.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.119.008097","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T09:00:13Z","timestamp":1568019613000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Propensity Score\u2013Adjusted Comparison of Long-Term Outcomes Among Revascularization Strategies for Critical Limb Ischemia"],"prefix":"10.1161","volume":"12","author":[{"given":"Jihad A.","family":"Mustapha","sequence":"first","affiliation":[{"name":"Advanced Cardiac &amp; Vascular Amputation Prevention Centers, Grand Rapids, MI (J.A.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry T.","family":"Katzen","sequence":"additional","affiliation":[{"name":"Division of Interventional Radiology, Miami Cardiac and Vascular Institute, FL (B.T.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard F.","family":"Neville","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Vascular Surgery, Inova Heart and Vascular Institute, Inova Fairfax Medical Campus, Falls Church, VA (R.F.N.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Lookstein","sequence":"additional","affiliation":[{"name":"Department of Radiology, Icahn School of Medicine at Mount Sinai, New York (R.A.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Zeller","sequence":"additional","affiliation":[{"name":"Department of Angiology, Universit\u00e4ts-Herzzentrum Freiburg-Bad Krozingen, Germany (T.Z.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry E.","family":"Miller","sequence":"additional","affiliation":[{"name":"Miller Scientific Consulting, Asheville, NC (L.E.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa R.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Technomics Research, Minneapolis, MN (T.R.N.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Jaff","sequence":"additional","affiliation":[{"name":"Department of Medicine, Newton-Wellesley Hospital, MA (M.R.J.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"On behalf of the Board of the CLI Global Society","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","unstructured":"American Cancer Society. 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