{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:14:53Z","timestamp":1790810093078,"version":"4.1.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The optimal revascularization strategy for acute limb ischemia (ALI) remains unclear, and contemporary comparative effectiveness data on endovascular versus surgical revascularization are lacking.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We used the 2010 to 2014 National Inpatient Sample databases to identify hospitalizations with a primary diagnosis of ALI. Patients were propensity-score matched on the likelihood of undergoing endovascular versus surgical revascularization using a logistic regression model. The primary outcome was in-hospital mortality. Secondary outcomes included myocardial infarction, stroke, composite of death\/myocardial infarction\/stroke, any amputation, fasciotomy, acute kidney injury, major bleeding, transfusion, vascular complications, length of stay, and hospital costs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Of 10 484 (weighted national estimate=51 914) hospitalizations for ALI, endovascular revascularization was performed in 5008 (47.8%) and surgical revascularization in 5476 (52.2%). In the propensity-score matched cohort (n=7746; 3873 per group), patients who underwent endovascular revascularization had significantly lower in-hospital mortality (2.8% versus 4.0%;\n              <jats:italic>P<\/jats:italic>\n              =0.002), myocardial infarction (1.9% versus 2.7%;\n              <jats:italic>P<\/jats:italic>\n              =0.022), composite of death\/myocardial infarction\/stroke (5.2% versus 7.5%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), acute kidney injury (10.5% versus 11.9%;\n              <jats:italic>P<\/jats:italic>\n              =0.043), fasciotomy (1.9% versus 8.9%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), major bleeding (16.7% versus 21.0%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and transfusion (10.3% versus 18.5%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), but higher vascular complications (1.4% versus 0.7%;\n              <jats:italic>P<\/jats:italic>\n              =0.002), compared with those undergoing surgical revascularization. Rates of any amputation were similar between the 2 groups (4.7% versus 5.1%;\n              <jats:italic>P<\/jats:italic>\n              =0.43). Median length of stay was shorter and hospital costs higher with endovascular versus surgical revascularization.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In patients with ALI, endovascular revascularization was associated with better in-hospital clinical outcomes compared with surgical revascularization. Contemporary randomized controlled trials are needed to determine the optimal revascularization strategy for ALI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.119.008150","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T10:00:35Z","timestamp":1579255235000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":60,"title":["Endovascular Versus Surgical Revascularization for Acute Limb Ischemia"],"prefix":"10.1161","volume":"13","author":[{"given":"Dhaval","family":"Kolte","sequence":"first","affiliation":[{"name":"Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston (D.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin F.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Statistical Consultant, Lifespan Cardiovascular Institute, Providence, RI (K.F.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi H.","family":"Shishehbor","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Case Western Reserve University and University Hospitals, Cleveland, OH (M.H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafiq T.","family":"Mamdani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Lifespan Cardiovascular Institute, Warren Alpert Medical School of Brown University, Providence, RI (S.T.M., O.N.H., P.S., H.D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Stangenberg","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Warren Alpert Medical School of Brown University, Providence, RI (L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar N.","family":"Hyder","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Lifespan Cardiovascular Institute, Warren Alpert Medical School of Brown University, Providence, RI (S.T.M., O.N.H., P.S., H.D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Soukas","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Lifespan Cardiovascular Institute, Warren Alpert Medical School of Brown University, Providence, RI (S.T.M., O.N.H., P.S., H.D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert D.","family":"Aronow","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Lifespan Cardiovascular Institute, Warren Alpert Medical School of Brown University, Providence, RI (S.T.M., O.N.H., P.S., H.D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1006054"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000471"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0950-821x(05)80239-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0741-5214(94)70214-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199409000-00003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0741-5214(96)70067-8"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(96)00129-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804163381603"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2017.03.03"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2017.11.030"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1526602815592849"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X16635291"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2014.03.015"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17653"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.117.003846"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.03.244"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.08.091"},{"key":"e_1_3_3_19_2","volume-title":"Healthcare Cost and Utilization Project (HCUP)","author":"Checklist for Working with the NIS","year":"2017","unstructured":"Checklist for Working with the NIS. 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