{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:09:01Z","timestamp":1785226141058,"version":"3.55.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Valve-in-valve transcatheter aortic valve replacement (TAVR) is an option when a surgical valve demonstrates deterioration and dysfunction. This study reports 3-year results following valve-in-valve with self-expanding TAVR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>The CoreValve US Expanded Use Study is a prospective, nonrandomized, single-arm study that evaluates safety and effectiveness of TAVR in extreme risk patients with symptomatic failed surgical biologic aortic valves. Study end points include all-cause mortality, need for valve reintervention, hemodynamic changes over time, and quality of life through 3 years. Patients were stratified by presence of preexisting surgical valve prosthesis-patient mismatch.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              From March 2013 to May 2015, 226 patients deemed extreme risk (STS-PROM [Society of Thoracic Surgeons Predicted Risk of Mortality] 9.0\u00b17%) had attempted valve-in-valve TAVR. Preexisting surgical valve prosthesis-patient mismatch was present in 47.2% of the cohort. At 3 years, all-cause mortality or major stroke was 28.6%, and 93% of patients were in New York Heart Association I or II heart failure. Valve performance was maintained over 3 years with low valve reintervention rates (4.4%), an improvement in effective orifice area over time and a 2.7% rate of severe structural valve deterioration. Preexisting severe prosthesis-patient mismatch was not associated with 3-year mortality but was associated with significantly less improvement in quality of life at 3-year follow-up (\n              <jats:italic>P<\/jats:italic>\n              =0.01).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Self-expanding TAVR in patients with failed surgical bioprostheses at extreme risk for surgery was associated with durable hemodynamics and excellent clinical outcomes. Preexisting surgical valve prosthesis-patient mismatch was not associated with mortality but did limit patient improvement in quality of life over 3-year follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01675440.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.119.008155","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T09:00:28Z","timestamp":1571043628000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Durability and Clinical Outcomes of Transcatheter Aortic Valve Replacement for Failed Surgical Bioprostheses"],"prefix":"10.1161","volume":"12","author":[{"given":"Harold L.","family":"Dauerman","sequence":"first","affiliation":[{"name":"University of Vermont Larner College of Medicine, Burlington (H.L.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Michael","family":"Deeb","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University of Michigan, Ann Arbor (G.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"O\u2019Hair","sequence":"additional","affiliation":[{"name":"Departments of Cardiac Surgery and Cardiology, Aurora Healthcare, Milwaukee, WI (D.P.O., T.B.)."},{"name":"Current address: Boulder Heart, CO (D.P.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Waksman","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology, MedStar Washington Hospital Center, DC (R.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Yakubov","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Riverside Methodist Hospital, Columbus, OH (S.J.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal S.","family":"Kleiman","sequence":"additional","affiliation":[{"name":"Departments of Cardiology and Cardiothoracic Surgery, Houston Methodist DeBakey Heart and Vascular Center, Houston, TX (N.S.K., M.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley J.","family":"Chetcuti","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Michigan, Ann Arbor (S.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"James B.","family":"Hermiller","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, St Vincent\u2019s Medical Center, IN (J.B.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvir","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Departments of Cardiac Surgery and Cardiology, Aurora Healthcare, Milwaukee, WI (D.P.O., T.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Khabbaz","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Surgery and Internal Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, MA (K.K., J.J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"de Marchena","sequence":"additional","affiliation":[{"name":"Divisions of Cardiology and Cardiothoracic Surgery, University of Miami Miller School of Medicine, Miami, FL (E.d.M., T.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Salerno","sequence":"additional","affiliation":[{"name":"Divisions of Cardiology and Cardiothoracic Surgery, University of Miami Miller School of Medicine, Miami, FL (E.d.M., T.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Dries-Devlin","sequence":"additional","affiliation":[{"name":"Coronary and Structural Heart Clinical Operations, Medtronic, Mounds View, MN (J.L.D.-D., S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Coronary and Structural Heart Clinical Operations, Medtronic, Mounds View, MN (J.L.D.-D., S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Popma","sequence":"additional","affiliation":[{"name":"Departments of Cardiovascular Surgery and Internal Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, MA (K.K., J.J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Reardon","sequence":"additional","affiliation":[{"name":"Departments of Cardiology and Cardiothoracic Surgery, Houston Methodist DeBakey Heart and Vascular Center, Houston, TX (N.S.K., 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