{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:40:00Z","timestamp":1792593600661,"version":"4.5.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Transcatheter mitral valve replacement using aortic transcatheter heart valves has recently become an alternative for patients with degenerated mitral bioprostheses, failed surgical repairs with annuloplasty rings or severe mitral annular calcification who are poor surgical candidates. Outcomes of these procedures are collected in the Society of Thoracic Surgeons\/American College of Cardiology\/Transcatheter Valve Therapy Registry. A comprehensive analysis of mitral valve-in-valve (MViV), mitral valve-in-ring (MViR), and valve-in-mitral annular calcification (ViMAC) outcomes has not been performed. We sought to evaluate short-term outcomes of early experience with MViV, MViR, and ViMAC in the United States.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Retrospective analysis of data from the Society of Thoracic Surgeons\/American College of Cardiology Transcatheter Valve Therapy Registry.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Nine hundred three high-risk patients (median Society of Thoracic Surgeons score 10%) underwent MViV (n=680), MViR (n=123), or ViMAC (n=100) between March 2013 and June 2017 at 172 hospitals. Median age was 75 years, 59.2% female. Technical and procedural success were higher in MViV. Left ventricular outflow tract obstruction occurred more frequently with ViMAC (ViMAC=10%, MViR=4.9%, MViV=0.7%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). In-hospital mortality (MViV=6.3%, MViR=9%, ViMAC=18%;\n              <jats:italic>P<\/jats:italic>\n              =0.004) and 30-day mortality (MViV=8.1%, MViR=11.5%, ViMAC=21.8%;\n              <jats:italic>P<\/jats:italic>\n              =0.003) were higher in ViMAC. At 30-day follow-up, median mean mitral valve gradient was 7 mm Hg, most patients (96.7%) had mitral regurgitation grade \u22641 (+) and were in New York Heart Association class I to II (81.7%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>MViV using aortic balloon-expandable transcatheter heart valves is associated with a low complication rate, a 30-day mortality lower than predicted by the Society of Thoracic Surgeons score, and superior short-term outcomes than MViR and ViMAC. At 30 days, patients in all groups experienced improvement of symptoms, and valve performance remained stable.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02245763.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.119.008425","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T10:00:36Z","timestamp":1583488836000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":199,"title":["Thirty-Day Outcomes of Transcatheter Mitral Valve Replacement for Degenerated Mitral Bioprostheses (Valve-in-Valve), Failed Surgical Rings (Valve-in-Ring), and Native Valve With Severe Mitral Annular Calcification (Valve-in-Mitral Annular Calcification) in the United States"],"prefix":"10.1161","volume":"13","author":[{"given":"Mayra","family":"Guerrero","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Hospital, Rochester, MN (M.G., M.E., A.K.C., G.S., D.H., C.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreekanth","family":"Vemulapalli","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (S.V., Q.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Xiang","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (S.V., Q.X.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dee Dee","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Henry Ford Hospital (D.D.W., W.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackram","family":"Eleid","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Hospital, Rochester, MN (M.G., M.E., A.K.C., G.S., D.H., C.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison K.","family":"Cabalka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Hospital, Rochester, MN (M.G., M.E., A.K.C., G.S., D.H., C.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpreet","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Hospital, Rochester, MN (M.G., M.E., A.K.C., G.S., D.H., C.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Salinger","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Froedtert Medical College of Wisconsin, Milwaukee (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyde","family":"Russell","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery (H.R.), NorthShore University Health System, Evanston, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"Structural Heart and Valve Center, Emory University, Atlanta, GA (A.G., V.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susheel","family":"Kodali","sequence":"additional","affiliation":[{"name":"Division of Cardiology (S.K., M.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"George","sequence":"additional","affiliation":[{"name":"Department of Surgery, Columbia University Medical Center, New York (I.G., V.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Dvir","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Washington Medical Center, Seattle (D.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Whisenant","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Intermountain Heart Institute, Salt Lake City, UT (B.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Rutgers Robert Wood Johnson Medical School in New Brunswick, NJ (M.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Pershad","sequence":"additional","affiliation":[{"name":"Division of Cardiology (A.P.), Banner University Medical Center, Phoenix, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenith","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Surgery (K.F.), Banner University Medical Center, Phoenix, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Coylewright","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH (M.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinak","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Brigham and Women\u2019s Hospital, Brighton, MA (P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilis","family":"Babaliaros","sequence":"additional","affiliation":[{"name":"Structural Heart and Valve Center, Emory University, Atlanta, GA (A.G., V.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaffar M.","family":"Khan","sequence":"additional","affiliation":[{"name":"Cardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD (J.M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Tommaso","sequence":"additional","affiliation":[{"name":"Division of Cardiology (C.T., T.F.), NorthShore University Health System, Evanston, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Saucedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saibal","family":"Kar","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cedar\u2019s Sinai Medical Center, Los Angeles, CA (S.K., R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajj","family":"Makkar","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cedar\u2019s Sinai Medical Center, Los Angeles, CA (S.K., R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mack","sequence":"additional","affiliation":[{"name":"Department of Surgery, Heart Hospital Baylor Plano, Baylor Healthcare System, TX (M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Hospital, Rochester, MN (M.G., M.E., A.K.C., G.S., D.H., C.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Leon","sequence":"additional","affiliation":[{"name":"Division of Cardiology (S.K., M.L.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayak","family":"Bapat","sequence":"additional","affiliation":[{"name":"Department of Surgery, Columbia University Medical Center, New York (I.G., V.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod H.","family":"Thourani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Marcus Valve Center, Piedmont Heart Institute, Atlanta, GA (V. H.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charanjit","family":"Rihal","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Hospital, Rochester, MN (M.G., M.E., A.K.C., G.S., D.H., C.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Henry Ford Hospital (D.D.W., W.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Feldman","sequence":"additional","affiliation":[{"name":"Division of Cardiology (C.T., T.F.), NorthShore University Health System, Evanston, IL."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000089184.46999.f4"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-923946"},{"key":"e_1_3_5_4_2","first-page":"557","article-title":"Second and third cardiac valve reoperations: factors influencing death and long-term survival.","volume":"36","author":"Toker ME","year":"2009","unstructured":"Toker, ME, Eren, E, Guler, M, Kirali, K, Yanartas, M, Balkanay, M, Yakut, C. Second and third cardiac valve reoperations: factors influencing death and long-term survival. Tex Heart Inst J. 2009;36:557\u2013562.","journal-title":"Tex Heart Inst J"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs005"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1885-5857(09)72658-1"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312047"},{"key":"e_1_3_5_8_2","first-page":"624","article-title":"Surgery for non-rheumatic calcific mitral stenosis.","volume":"20","author":"Vohra HA","year":"2011","unstructured":"Vohra, HA, Whistance, RN, Bezuska, L, Livesey, SA. Surgery for non-rheumatic calcific mitral stenosis. J Heart Valve Dis. 2011;20:624\u2013626.","journal-title":"J Heart Valve Dis"},{"key":"e_1_3_5_9_2","first-page":"387","article-title":"[Rupture of the posterior wall of the left ventricule after replacement of the mitral valve: a description of 8 cases (author\u2019s transl)].","volume":"7","author":"Casarotto D","year":"1977","unstructured":"Casarotto, D, Bortolotti, U, Thiene, G, Gallucci, V, C\u00e9vese, PG. [Rupture of the posterior wall of the left ventricule after replacement of the mitral valve: a description of 8 cases (author\u2019s transl)]. G Ital Cardiol. 1977;7:387\u2013394.","journal-title":"G Ital Cardiol"},{"key":"e_1_3_5_10_2","volume-title":"Transcatheter mitral valve-invalve \/ valve-in-ring. Data presented at Transcatheter Valcular Therapeutics. June 2017","author":"Dvir D","year":"2017","unstructured":"Dvir, D. Transcatheter mitral valve-invalve \/ valve-in-ring. Data presented at Transcatheter Valcular Therapeutics. June 2017, Chicago, IL. 2017. https:\/\/http:\/\/www.tctmd.com\/slide\/tav-mitral-surgical-valves-and-rings-lessons-vivid-registry. Accessed Augest 27, 2018."},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.07.714"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.08.014"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy590"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.04.022"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.054"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy271"},{"key":"e_1_3_5_17_2","unstructured":"Guerrero M. Mitral trial (mitral implantation of transcatheter valves) clinicaltrials.gov identifier nct02370511. https:\/\/clinicaltrials.Gov\/ct2\/show\/nct02370511. Accessed November 13 2019."},{"key":"e_1_3_5_18_2","volume-title":"Data presented as Late Breaking Clinical Trial at Transcatheter Cardiovascular Therapeutics Scientific Symposium 2017","author":"Guerrero M","unstructured":"Guerrero, M. 30-day outcomes of transcatheter mitral valve replacement in patient with severe mitral valve disease secondary to mitral annular calcification of failed annuloplasty rings. Data presented as Late Breaking Clinical Trial at Transcatheter Cardiovascular Therapeutics Scientific Symposium 2017. November 1, 2017; San Francisco, California."},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.136.suppl_1.23085"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.033"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.060"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.005"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv333"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.01.017"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27447"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.06.020"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.01.035"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.033"},{"key":"e_1_3_5_29_2","doi-asserted-by":"crossref","unstructured":"Lederman RJ. Lampoon study: Intentional laceration of the anterior mitral leaflet to prevent left ventricular outflow tract obstruction during transcatheter mitral valve implantation. Https:\/\/clinicaltrials.Gov\/ct2\/show\/nct03015194?Term=lampoon&rank=1. Accessed January 28 2019.","DOI":"10.1136\/heartjnl-2018-BCIS.2"},{"key":"e_1_3_5_30_2","unstructured":"Smith R. Surgical implantation of transcatheter valve in native mitral annular calcification (sitral) study. Https:\/\/clinicaltrials.Gov\/ct2\/show\/nct02830204?Term=surgical+implantation+of+transcatheter+valves&rank=1. Accessed January 28 2019."}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.119.008425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T18:35:55Z","timestamp":1737052555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.119.008425"}},"subtitle":["Data From the Society of Thoracic Surgeons\/American College of Cardiology\/Transcatheter Valve Therapy Registry"],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.119.008425"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.119.008425","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"2019-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e008425"}}