{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:28:39Z","timestamp":1785425319265,"version":"3.56.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Women are more likely to suffer and die from cardiogenic shock (CS) as the most severe complication of acute myocardial infarction. Data concerning optimal management for women with CS are scarce. Aim of this study was to better define characteristics of women experiencing CS and to the influence of sex on different treatment strategies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>In the CULPRIT-SHOCK trial (The Culprit Lesion Only PCI Versus Multivessel PCI in Cardiogenic Shock), patients with CS complicating acute myocardial infarction and multivessel coronary artery disease were randomly assigned to one of the following revascularization strategies: either percutaneous coronary intervention of the culprit-lesion-only or immediate multivessel percutaneous coronary intervention. Primary end point was composite of death from any cause or severe renal failure leading to renal replacement therapy within 30 days. We investigated sex-specific differences in general and according to the revascularization strategies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Among all 686 randomized patients included in the analysis, 24% were women. Women were older and had more often diabetes mellitus and renal insufficiency, whereas they had less often history of previous acute myocardial infarction and smoking. After 30 days, the primary clinical end point was not significantly different between groups (56% women versus 49% men; odds ratio, 1.29 [95% CI, 0.91\u20131.84];\n              <jats:italic>P<\/jats:italic>\n              =0.15). There was no interaction between sex and coronary revascularization strategy regarding mortality and renal failure (\n              <jats:italic>P<\/jats:italic>\n              <jats:sub>interaction<\/jats:sub>\n              =0.11). The primary end point occurred in 56% of women treated by the culprit-lesion-only strategy versus 42% men, whereas 55% of women and 55% of men in the multivessel percutaneous coronary intervention group.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Although women presented with a different risk profile, mortality and renal replacement were similar to men. Sex did not influence mortality and renal failure according to the different coronary revascularization strategies. Based on these data, women and men presenting with CS complicating acute myocardial infarction and multivessel coronary artery disease should not be treated differently. However, further randomized trials powered to address potential sex-specific differences in CS are still necessary.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01927549.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.119.008537","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T09:00:17Z","timestamp":1583830817000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Sex-Specific Management in Patients With Acute Myocardial Infarction and Cardiogenic Shock"],"prefix":"10.1161","volume":"13","author":[{"given":"Maria","family":"Rubini Gimenez","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine\/Cardiology, Heart Center Leipzig, Germany (M.R.G., S.D., H.T.)."},{"name":"Cardiology Department, University Hospital Basel, Switzerland (M.R.G., R.V.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Zeymer","sequence":"additional","affiliation":[{"name":"Klinikum Ludwigshafen, Germany (U.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Desch","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine\/Cardiology, Heart Center Leipzig, Germany (M.R.G., S.D., H.T.)."},{"name":"German Center for Cardiovascular Research, Berlin, Germany (S.D., R.M.-S., G.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"de Waha-Thiele","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology\/ Angiology\/Intensive Care Medicine, University Heart Center L\u00fcbeck, Germany (S.d.W.-T., J.P., R.M.-S., G.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoufik","family":"Ouarrak","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Herzinfarktforschung, Ludwigshafen, Germany (T.O., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Poess","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology\/ Angiology\/Intensive Care Medicine, University Heart Center L\u00fcbeck, Germany (S.d.W.-T., J.P., R.M.-S., G.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza","family":"Meyer-Saraei","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research, Berlin, Germany (S.D., R.M.-S., G.F.)."},{"name":"Department of Internal Medicine\/Cardiology\/ Angiology\/Intensive Care Medicine, University Heart Center L\u00fcbeck, Germany (S.d.W.-T., J.P., R.M.-S., G.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Schneider","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Herzinfarktforschung, Ludwigshafen, Germany (T.O., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Fuernau","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research, Berlin, Germany (S.D., R.M.-S., G.F.)."},{"name":"Department of Internal Medicine\/Cardiology\/ Angiology\/Intensive Care Medicine, University Heart Center L\u00fcbeck, Germany (S.d.W.-T., J.P., R.M.-S., G.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Stepinska","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Warsaw, Poland (J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Huber","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine, Cardiology and Intensive Care Medicine, Wilhelminenhospital and Sigmund Freud University, Medical School, Vienna, Austria (K.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (S.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Montalescot","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sorbonne Universit\u00e9, Institut de Cardiologie (AP-HP), h\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France 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