{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:39:28Z","timestamp":1792075168241,"version":"4.4.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Large data comparing the performance of new-generation self-expandable versus balloon-expandable transcatheter heart valves in bicuspid aortic stenosis are lacking. We aim to compare the safety and performance of balloon-expandable and self-expandable transcatheter heart valves in the treatment of bicuspid aortic stenosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>The BEAT (balloon versus self-expandable valve for the treatment of bicuspid aortic valve stenosis) registry included 353 consecutive patients who underwent transcatheter aortic valve implantation using new-generation Evolut R\/PRO or Sapien 3 valves in bicuspid aortic valve.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              A total of 353 patients (n=242 [68.6%] treated with Sapien 3 and n=111 [68.6%] treated with Evolut R (n=70)\/PRO [n=41]) were included. Mean age was 77.8\u00b18.3 years and mean Society of Thoracic Surgeons Predicted Risk of Mortality was 4.4\u00b13.3%. Valve Academic Research Consortium-2 device success was similar between Sapien 3 and Evolut R\/PRO (85.6% versus 87.2%;\n              <jats:italic>P<\/jats:italic>\n              =0.68). In the Sapien 3 group, 4 patients experienced annular rupture whereas this complication did not occur in the Evolut R\/PRO group. After propensity score matching, Valve Academic Research Consortium-2 device success was similar between both groups (Sapien 3=85.7% versus Evolut R\/Pro=84.4%;\n              <jats:italic>P<\/jats:italic>\n              =0.821). Both in the overall and in the matched population, no differences in the rate of permanent pacemaker implant were observed. At 1-year follow-up, the rate of overall death and cardiovascular death were similar between the 2 groups. In the unmatched population, the 1-year echocardiographic follow-up demonstrated similar rate of moderate-to-severe paravalvular aortic regurgitation (Evolut R\/PRO 10.5% versus Sapien 3 4.2%,\n              <jats:italic>P<\/jats:italic>\n              =0.077); however, after propensity matching, the rate of moderate-to-severe paravalvular leak became significantly higher among patients treated with self-expandable valves (9.3% versus 0%;\n              <jats:italic>P<\/jats:italic>\n              =0.043).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Our study confirms the feasibility of both Sapien 3 and Evolut R\/PRO implantation in bicuspid aortic valve anatomy; a higher rate of moderate-severe paravalvular aortic regurgitation was observed in the Evolut R\/PRO group at 1-year follow-up in the matched cohort, although patients treated with balloon-expandable valve had a higher rate of annular rupture.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.119.008714","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T09:00:22Z","timestamp":1594371622000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":113,"title":["Balloon Versus Self-Expandable Valve for the Treatment of Bicuspid Aortic Valve Stenosis"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3239-4046","authenticated-orcid":true,"given":"Antonio","family":"Mangieri","sequence":"first","affiliation":[{"name":"GVM Care and Research, Maria Cecilia Hospital, Cotignola, Ravenna, Italy (A.M., F.G., A.L., F.G., A.C.)."},{"name":"San Raffaele Scientific Institute, Milan, Italy (A.M., M.P., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Tchetch\u00e8","sequence":"additional","affiliation":[{"name":"Groupe CardioVasculaire Interventionnel, Clinique Pasteur, Toulouse (D.T., C.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart Center, Department of Cardiology, Bad Nauheim, Germany (W.-K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pagnesi","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute, Milan, Italy (A.M., M.P., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Malte","family":"Sinning","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Bonn, Germany (J.-M.S., G.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Landes","sequence":"additional","affiliation":[{"name":"Cardiology Department, Rabin Medical Center, Petah Tikva, Israel (U.L., R.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Kornowski","sequence":"additional","affiliation":[{"name":"Cardiology Department, Rabin Medical Center, Petah Tikva, Israel (U.L., R.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"De Backer","sequence":"additional","affiliation":[{"name":"The Heart Center-Rigshospitalet, Copenhagen, Denmark (O.D.B., L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Bonn, Germany (J.-M.S., G.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Ielasi","sequence":"additional","affiliation":[{"name":"Istituto clinic Sant\u2019Ambrogio, Milan, Italy (A.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"De Biase","sequence":"additional","affiliation":[{"name":"Groupe CardioVasculaire Interventionnel, Clinique Pasteur, Toulouse (D.T., C.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"The Heart Center-Rigshospitalet, Copenhagen, Denmark (O.D.B., L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"De Marco","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Istituto Clinico San Donato, Milan, Italy (F.D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute, Milan, Italy (A.M., M.P., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Chiarito","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy (M.C., D.R., G.S., P.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiano","family":"Regazzoli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy (M.C., D.R., G.S., P.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Stefanini","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy (M.C., D.R., G.S., P.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Presbitero","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy (M.C., D.R., G.S., P.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Toggweiler","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Luzerner Kantonsspital, Switzerland (S.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[{"name":"Cardiology Division, CAST Policlinico Hospital, University of Catania, Italy (C.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Imm\u00e8","sequence":"additional","affiliation":[{"name":"Centro cuore Morgagni, Catania, Italy (S.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"Interventional Cardiology unit, University of Padova, Italy (G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Sievert","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Frankfurt, Germany (H.S.)."},{"name":"Anglia Ruskin University, Chelmsford, United Kingdom (H.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"UKE Hamburg, Germany (U.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Kempfert","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum Berlin, Charit\u00e9 Universit\u00e4tsmedizin, Germany (J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"W\u00f6ehrle","sequence":"additional","affiliation":[{"name":"Ulm University, Germany (J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Gallo","sequence":"additional","affiliation":[{"name":"GVM Care and Research, Maria Cecilia Hospital, Cotignola, Ravenna, Italy (A.M., F.G., A.L., F.G., A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Laricchia","sequence":"additional","affiliation":[{"name":"GVM Care and 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