{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:28:19Z","timestamp":1792290499499,"version":"4.4.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vascular injury and inflammation during percutaneous coronary intervention (PCI) are associated with increased risk of post-PCI adverse outcomes. Colchicine decreases neutrophil recruitment to sites of vascular injury. The anti-inflammatory effects of acute colchicine administration before PCI on subsequent myocardial injury are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a prospective, single-site trial, subjects referred for possible PCI (n=714) were randomized to acute preprocedural oral administration of colchicine 1.8 mg or placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among the 400 subjects who underwent PCI, the primary outcome of PCI-related myocardial injury did not differ between colchicine (n=206) and placebo (n=194) groups (57.3% versus 64.2%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.19). The composite outcome of death, nonfatal myocardial infarction, and target vessel revascularization at 30 days (11.7% versus 12.9%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.82), and the outcome of PCI-related myocardial infarction defined by the Society for Cardiovascular Angiography and Interventions (2.9% versus 4.7%,\n                      <jats:italic>P<\/jats:italic>\n                      =0.49) did not differ between colchicine and placebo groups. Among 280 PCI subjects in a nested inflammatory biomarker substudy, the primary biomarker end point, change in interleukin-6 concentrations did not differ between groups 1-hour post-PCI but increased less 24 hours post-PCI in the colchicine (n=141) versus placebo group (n=139; 76% [\u22126 to 898] versus 338% [27 to 1264],\n                      <jats:italic>P<\/jats:italic>\n                      =0.02). High-sensitivity C-reactive protein concentration also increased less after 24 hours in the colchicine versus placebo groups (11% [\u221214 to 80] versus 66% [1 to 172],\n                      <jats:italic>P<\/jats:italic>\n                      =0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Acute preprocedural administration of colchicine attenuated the increase in interleukin-6 and high-sensitivity C-reactive protein concentrations after PCI when compared with placebo but did not lower the risk of PCI-related myocardial injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique Identifiers: NCT02594111, NCT01709981.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.119.008717","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T05:01:36Z","timestamp":1587013296000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":178,"title":["Effects of Acute Colchicine Administration Prior to Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-8001","authenticated-orcid":false,"given":"Binita","family":"Shah","sequence":"first","affiliation":[{"name":"Section of Cardiology, Department of Medicine (B.S., J.D.L., N.R.S.), VA New York Harbor Health Care System."},{"name":"Division of Cardiology, Department of Medicine (B.S., J.D.L., N.R.S., F.F., N.R., N.M.K., S.D.K.), New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pillinger","sequence":"additional","affiliation":[{"name":"Section of Rheumatology, Department of Medicine (M.P.), VA New York Harbor Health Care System."},{"name":"Division of Rheumatology, Department of Medicine (M.P., B.C.), New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhong","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Population Health (H.Z., Y.X.), New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Cronstein","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine (M.P., B.C.), New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhe","family":"Xia","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Department of Population Health (H.Z., Y.X.), New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Lorin","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine (B.S., J.D.L., N.R.S.), VA New York Harbor Health Care System."},{"name":"Division of Cardiology, Department of Medicine (B.S., J.D.L., N.R.S., F.F., N.R., N.M.K., S.D.K.), New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel R.","family":"Smilowitz","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine (B.S., J.D.L., N.R.S.), VA New York Harbor Health Care System."},{"name":"Division of Cardiology, Department of Medicine (B.S., J.D.L., N.R.S., 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of drug transporter gene ABCB1 (MDR1) 3435C to T polymorphism with colchicine response in familial Mediterranean fever.","volume":"34","author":"Tufan A","year":"2007","unstructured":"Tufan, A, Babaoglu, MO, Akdogan, A, Yasar, U, Calguneri, M, Kalyoncu, U, Karadag, O, Hayran, M, Ertenli, AI, Bozkurt, A, et al. 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