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However, rapid advancement in the field has resulted in approval of edge-to-edge mitral valve repair with the MitraClip, and there are several novel catheter-based percutaneous options in clinical trials. Percutaneous options, while promising, must be deployed in patients who are most likely to benefit, and thus, understanding the pathophysiology of specific subgroups of patients with functional mitral regurgitation (eg, disproportionate versus proportionate mitral regurgitation) is key to the success of new devices. We review the pathophysiology, percutaneous therapeutic treatment options, and ongoing clinical trials for functional mitral regurgitation.<\/jats:p>","DOI":"10.1161\/circinterventions.120.008998","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T09:00:29Z","timestamp":1596704429000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Percutaneous Interventions for Secondary Mitral Regurgitation"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0986-8992","authenticated-orcid":true,"given":"Mahboob","family":"Ali","sequence":"first","affiliation":[{"name":"University of Cincinnati, OH (M.A., D.N.P., D.R.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satya S.","family":"Shreenivas","sequence":"additional","affiliation":[{"name":"The Christ Hospital, Cincinnati, OH (S.S.S., D.J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Pratt","sequence":"additional","affiliation":[{"name":"University of Cincinnati, OH (M.A., D.N.P., D.R.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald R.","family":"Lynch","sequence":"additional","affiliation":[{"name":"University of Cincinnati, OH (M.A., D.N.P., D.R.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean J.","family":"Kereiakes","sequence":"additional","affiliation":[{"name":"The Christ Hospital, Cincinnati, OH (S.S.S., D.J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hjc.2019.02.003"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.08.723"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007885"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00558-4"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-018-1058-8"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30473-2"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.02.009"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000503"},{"key":"e_1_3_4_12_2","volume-title":"Hurst\u2019s the Heart, 14th Edition: Two Volume Set","author":"Fuster V","year":"2017","unstructured":"FusterVHarringtonRANarulaJEapenZJ.Hurst\u2019s the Heart, 14th Edition: Two Volume Set. 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