{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:08:14Z","timestamp":1790784494878,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Interventional therapies aiming at excluding the left atrial appendage (LAA) from systemic circulation have been established as a valid alternative to oral anticoagulation in patients at high thromboembolic risk. However, their efficacy on stroke prophylaxis may be compromised owing to incomplete LAA closure. Additionally, the need for an alternative thromboembolic prevention may remain unmet in patients with contraindications to oral anticoagulation whose appendage anatomy is unsuitable for some conventional devices commercially available. We aimed at evaluating the feasibility of LAA closure with the novel Gore Cardioform Septal Occluder in patients with incomplete appendage ligation or anatomic features which do not meet the manufacturer\u2019s requirements for Watchman deployment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Twenty-one consecutive patients (mean age: 72\u00b16 years; 85.7% males; CHA\n              <jats:sub>2<\/jats:sub>\n              DS\n              <jats:sub>2<\/jats:sub>\n              -VASc: 4.5\u00b11.4; HAS-BLED: 3.6\u00b11.0) were included. Transesophageal echocardiography was performed within 2 months to assess for residual LAA patency.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Fourteen patients had incomplete LAA closure following surgical (n=6) or Lariat ligation (n=8). In 7 patients with an appendage anatomy unsuitable for Watchman deployment, the mean maximal landing zone size and LAA depth were 14.4\u00b11.3 and 18.6\u00b12.8 mm. Successful Cardioform Septal Occluder deployment was achieved in all patients. No peri-procedural complications were documented. Procedure and fluoroscopy times were 46\u00b113 and 14\u00b15 minutes. Follow-up transesophageal echocardiography after 58\u00b19 days revealed complete LAA closure in all patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Transcatheter LAA closure via a Cardioform Septal Occluder device might be a valid alternative in patients with residual leaks following failed appendage ligation or whose LAA anatomy does not meet the minimal anatomic criteria to accommodate a Watchman device.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphic Abstract:<\/jats:title>\n            <jats:p>\n              A\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"graphic abstract\">graphic abstract<\/jats:ext-link>\n              is available for this article.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.120.009227","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T09:00:16Z","timestamp":1600419616000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Use of a Novel Septal Occluder Device for Left Atrial Appendage Closure in Patients With Postsurgical and Postlariat Leaks or Anatomies Unsuitable for Conventional Percutaneous Occlusion"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-3462","authenticated-orcid":true,"given":"Domenico G.","family":"Della Rocca","sequence":"first","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center, Austin (D.G.D.R., R.P.H., C.T., Q.C., S.M., A.A., C.G., M.B., A.A.-A., J.D.B., G.J.G., L.D.B., A.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney P.","family":"Horton","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center, Austin (D.G.D.R., R.P.H., C.T., Q.C., S.M., A.A., C.G., M.B., A.A.-A., J.D.B., G.J.G., L.D.B., A.N.)."},{"name":"Department of Biomedical Engineering, Cockrell School of Engineering (R.P.H.), University of Texas, Austin."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9770-8675","authenticated-orcid":true,"given":"Nicola","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Arrhythmia Services, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (N.T., L.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffel Johannes","family":"Van Niekerk","sequence":"additional","affiliation":[{"name":"Interventional Electrophysiology, Scripps Clinic, La Jolla, CA (C.J.V.N., M.P., D.N.G., A.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chintan","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center, Austin (D.G.D.R., R.P.H., C.T., Q.C., S.M., A.A., C.G., M.B., A.A.-A., J.D.B., G.J.G., L.D.B., A.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center, Austin (D.G.D.R., R.P.H., C.T., Q.C., S.M., A.A., C.G., M.B., A.A.-A., J.D.B., G.J.G., L.D.B., A.N.)."},{"name":"Department of Cardiopulmonary Function Test, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, China (Q.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghamitra","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center, Austin (D.G.D.R., R.P.H., C.T., Q.C., S.M., A.A., C.G., M.B., A.A.-A., J.D.B., G.J.G., L.D.B., A.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisara","family":"Anannab","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center, Austin (D.G.D.R., R.P.H., C.T., Q.C., S.M., A.A., C.G., M.B., A.A.-A., J.D.B., G.J.G., L.D.B., A.N.)."},{"name":"Department of Cardiovascular Intervention, Central Chest Institute of Thailand, Nonthaburi (A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam","family":"Murtaza","sequence":"additional","affiliation":[{"name":"Kansas City Heart Rhythm Institute at HCA Midwest Health (G.M., K.A., D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Akella","sequence":"additional","affiliation":[{"name":"Kansas City Heart Rhythm Institute at HCA Midwest Health (G.M., K.A., D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-7207","authenticated-orcid":true,"given":"Carola","family":"Gianni","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center, Austin (D.G.D.R., R.P.H., C.T., Q.C., S.M., A.A., C.G., M.B., A.A.-A., J.D.B., G.J.G., L.D.B., A.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Bassiouny","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center, Austin (D.G.D.R., R.P.H., C.T., Q.C., S.M., A.A., C.G., M.B., A.A.-A., J.D.B., G.J.G., L.D.B., A.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Ahmadian-Tehrani","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center, Austin (D.G.D.R., R.P.H., C.T., Q.C., S.M., A.A., C.G., M.B., A.A.-A., J.D.B., G.J.G., L.D.B., A.N.)."},{"name":"Division of Internal Medicine, Department of Medicine, University of Texas Health Science Center, San Antonio (A.A.-T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8547-025X","authenticated-orcid":true,"given":"Amin","family":"Al-Ahmad","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center, Austin (D.G.D.R., R.P.H., C.T., Q.C., S.M., A.A., C.G., M.B., A.A.-A., J.D.B., G.J.G., L.D.B., A.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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Joseph","family":"Gallinghouse","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute, St. David\u2019s Medical Center, Austin (D.G.D.R., R.P.H., C.T., Q.C., S.M., A.A., C.G., M.B., A.A.-A., J.D.B., G.J.G., L.D.B., A.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas N.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Interventional Electrophysiology, Scripps Clinic, La Jolla, CA (C.J.V.N., M.P., D.N.G., A.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1492-2693","authenticated-orcid":true,"given":"Dhanunjaya","family":"Lakkireddy","sequence":"additional","affiliation":[{"name":"Kansas City Heart Rhythm Institute at HCA Midwest Health (G.M., K.A., D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-4047","authenticated-orcid":true,"given":"Luigi","family":"Di 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