{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:00:18Z","timestamp":1785402018906,"version":"3.56.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Prognostic impact of residual anatomic disease burden after functionally complete percutaneous coronary intervention (PCI), defined by post-PCI fractional flow reserve (FFR) &gt;0.80 would be a clinically relevant question. The current study evaluated clinical outcomes at 2 years according to residual Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) score (RSS) in patients who underwent functionally complete revascularization.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A total of 1910 patients (2095 revascularized vessels) with post-PCI FFR &gt;0.80 were selected from the International Post-PCI FFR Registry. RSS was defined as the SYNTAX score recalculated after PCI, SYNTAX revascularization index was calculated as 100\u00d7(1\u2212RSS\/pre-PCI SYNTAX score), and post-PCI FFR was measured after completion of PCI. The primary outcome was target vessel failure (TVF; a composite of cardiac death, target vessel\u2013related myocardial infarction, and clinically driven target vessel revascularization) at 2 years, and risk of TVF was compared according to tertile classification of RSS (0, 1\u20135, and &gt;5) and post-PCI FFR (\u22650.94, 0.87\u20130.93, and \u22640.86).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              After PCI, SYNTAX score was changed from 10.0 (Q1\u2013Q3, 7.0\u201316.0) to 0.0 (Q1\u2013Q3, 0.0\u20135.0) and FFR changed from 0.70\u00b10.12 to 0.90\u00b10.05. TVF at 2 years occurred in 4.9%, and patients with TVF showed higher pre-PCI SYNTAX score and lower post-PCI FFR than those without. However, there were no significant differences in SYNTAX revascularization index and RSS. The risk of TVF was not different according to tertile of RSS (log-rank\n              <jats:italic>P<\/jats:italic>\n              =0.851). Conversely, risk of TVF was different according to tertile of post-PCI FFR (log-rank\n              <jats:italic>P<\/jats:italic>\n              =0.009). Multivariable model showed the risk of TVF was significantly associated with post-PCI FFR (hazard ratio, 1.091 [95% CI, 1.032\u20131.153];\n              <jats:italic>P<\/jats:italic>\n              =0.002) but not with RSS (hazard ratio, 0.969 [95% CI, 0.898\u20131.045];\n              <jats:italic>P<\/jats:italic>\n              =0.417).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Among patients who underwent functionally complete revascularization, residual anatomic disease burden assessed by RSS was not related with occurrence of TVF at 2 years. These results support the importance of functionally complete revascularization rather than angiographic complete revascularization.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT04012281.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.120.009232","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T09:00:26Z","timestamp":1599555626000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Prognostic Impact of Residual Anatomic Disease Burden After Functionally Complete Revascularization"],"prefix":"10.1161","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct04012281","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Joo Myung","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (J.M.L., K.H.C., Y.B.S., J.-Y.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doyeon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Korea (D.H., B.-K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Hong","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (J.M.L., K.H.C., Y.B.S., J.-Y.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-0778","authenticated-orcid":true,"given":"Hyun-Jong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sejong General Hospital, Bucheon, Korea (H.-J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3986-9152","authenticated-orcid":true,"given":"Young Bin","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (J.M.L., K.H.C., Y.B.S., J.-Y.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Kyeong","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea (Y.-K.C., C.-W.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3370-5774","authenticated-orcid":true,"given":"Chang-Wook","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea (Y.-K.C., C.-W.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Yong","family":"Hahn","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (J.M.L., K.H.C., Y.B.S., J.-Y.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-6968","authenticated-orcid":true,"given":"Eun-Seok","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Ulsan Hospital, Korea (E.-S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon-Hyung","family":"Doh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea (J.-H.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (M.H., R.H., Y.K., T.M., T.K.), Tsuchiura Kyodo General Hospital, Ibaraki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikuta","family":"Hamaya","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (M.H., R.H., Y.K., T.M., T.K.), Tsuchiura Kyodo General Hospital, Ibaraki, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Kanaji","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (M.H., R.H., Y.K., T.M., T.K.), Tsuchiura Kyodo General Hospital, Ibaraki, 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S.-L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9031-4684","authenticated-orcid":true,"given":"Xiaobo","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Nanjing First Hospital, Nanjing Medical University, China (J.-J.Z., F.Y., X.L., Z.G., S.-L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Ge","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Nanjing First Hospital, Nanjing Medical University, China (J.-J.Z., F.Y., X.L., Z.G., S.-L.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Nanjing First Hospital, Nanjing Medical University, China (J.-J.Z., F.Y., X.L., Z.G., 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